The Crosstalk of Apoptotic and Non-Apoptotic Signaling in CD95 System [PDF]
CellsThe mechanisms of CD95 (Fas/APO-1)-mediated extrinsic apoptotic pathway in cancer cells have been extensively studied. The majority of human cells express CD95, but not all these cells can induce extrinsic apoptosis.
Kamil Seyrek +3 more
doaj +4 more sources
Genistein–Butein Co-Treatment Suppresses Glycolytic Metabolism and Induces Apoptotic Signaling in PC-3 Prostate Cancer Cells [PDF]
Current Issues in Molecular BiologyProstate cancer progression involves metabolic reprogramming that supports sustained proliferation and survival, highlighting metabolic pathways as potential targets for intervention.
Moon-Kyun Cho +4 more
doaj +2 more sources
TRAIL-induced variation of cell signaling states provides nonheritable resistance to apoptosis [PDF]
Life Science Alliance, 2019 This work summarizes cellular apoptotic and signaling response to TRAIL across 10 cell lines and for the first time links signaling diversity to nongenetic resistance. This high-dimensional, single-cell approach toward TRAIL resistance sets a standard in
Reema Baskar +8 more
doaj +3 more sources
Evolution of Apoptotic Signaling Pathways Within Lophotrochozoans. [PDF]
Genome Biol Evol, 2023 Abstract Apoptosis is the main form of regulated cell death in metazoans. Apoptotic pathways are well characterized in nematodes, flies, and mammals, leading to a vision of the conservation of apoptotic pathways in metazoans. However, we recently showed that intrinsic apoptosis is in fact divergent among metazoans.
Horkan HR +4 more
europepmc +3 more sources
Targeting STAU1 prevents p53 apoptotic signaling in neurodegeneration [PDF]
Cell Death and DiseaseStress responses and neuronal death mediated by the p53 pathway play a central role in the progression of neurodegenerative disease, constituting a common target to extend neuronal function and survival.
Mandi Gandelman +6 more
doaj +2 more sources
Acetylation-dependent coupling between G6PD activity and apoptotic signaling [PDF]
Nature Communications, 2023 Lysine acetylation has been discovered in thousands of non-histone human proteins, including most metabolic enzymes. Deciphering the functions of acetylation is key to understanding how metabolic cues mediate metabolic enzyme regulation and cellular ...
Fang Wu +7 more
doaj +2 more sources
Apoptotic signaling pathways in bone metastatic lung cancer: a comprehensive analysis [PDF]
Discover OncologyThis review provides a comprehensive analysis of apoptotic signaling pathways in the context of bone metastatic lung cancer, emphasizing the intricate molecular mechanisms and microenvironmental influences.
Yi Zhang +4 more
doaj +2 more sources
Exercise-induced signaling pathways to counteracting cardiac apoptotic processes
Frontiers in Cell and Developmental Biology, 2022 Cardiovascular diseases are the most common cause of death in the world. One of the major causes of cardiac death is excessive apoptosis. However, multiple pathways through moderate exercise can reduce myocardial apoptosis.
Hamed Alizadeh Pahlavani
doaj +1 more source
Uterine Endoplasmic Reticulum Stress and Its Unfolded Protein Response May Regulate Caspase 3 Activation in the Pregnant Mouse Uterus [PDF]
, 2013 We have previously proposed that uterine caspase-3 may modulate uterine contractility in a gestationally regulated fashion. The objective of this study was to determine the mechanism by which uterine caspase-3 is activated and consequently controlled in ...
Condon, Jennifer C. +5 more
core +12 more sources
Cell Death Related Proteins Beyond Apoptosis in the CNS
Frontiers in Cell and Developmental Biology, 2022 Cell death related (CDR) proteins are a diverse group of proteins whose original function was ascribed to apoptotic cell death signaling. Recently, descriptions of non-apoptotic functions for CDR proteins have increased. In this minireview, we comment on
Bazhena Bahatyrevich-Kharitonik +5 more
doaj +1 more source