Results 91 to 100 of about 127,331 (261)

Winter tick sharing between ungulates in the Greater Yellowstone Ecosystem and implications for apparent competition

open access: yesEcosphere
Host species heterogeneity can drive parasite dynamics through variation in host competency as well as host abundance. We explored how elk (Cervus canadensis) with apparent subclinical infestations of winter tick (Dermacentor albipictus) may be a cryptic
Troy Koser   +11 more
doaj   +1 more source

Local governments competing for the environment and green innovation-evidence from China

open access: yesJournal of Applied Economics
Enhancing green innovation is the key to realizing high-quality development and the “dual-carbon” goal. This paper takes the data from Chinese cities from 2000 to 2018 as a sample to test the impact and mechanism of local governments’ competition for the
Kai Wan
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Pricing to Market Behavior: Evidence from Selected Canadian and U.S. Agri-Food Exports

open access: yesJournal of Agricultural and Resource Economics, 2000
This study examines the pricing behavior of Canadian and U.S. agri-food exporters consistent with a model that permits the identification of pricing to market (PTM) behavior and imperfect market competition in agri-food markets.
Richard Carew
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

open access: yesMolecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Cell competition in primary and metastatic colorectal cancer

open access: yesOncogenesis
Adult tissues set the scene for a continuous battle between cells, where a comparison of cellular fitness results in the elimination of weaker “loser” cells. This phenomenon, named cell competition, is beneficial for tissue integrity and homeostasis.
Merel Elise van Luyk   +3 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Food Web Assembly Rules for Generalized Lotka-Volterra Equations.

open access: yesPLoS Computational Biology, 2016
In food webs, many interacting species coexist despite the restrictions imposed by the competitive exclusion principle and apparent competition. For the generalized Lotka-Volterra equations, sustainable coexistence necessitates nonzero determinant of the
Jan O Haerter   +2 more
doaj   +1 more source

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