Results 51 to 60 of about 31,242 (304)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Controlling the Spatial Direction of Hydrothermally Grown Rutile TiO₂ Nanocrystals by the Orientation of Seed Crystals

Crystals, 2019
Hydrothermally grown TiO2 nanorods are a key material for several electronic applications. Due to its anisotropic crystal structure, the electronic properties of this semiconductor depend on the crystallographic direction.
Julian Kalb, James A. Dorman, Stephan Siroky, Lukas Schmidt-Mende   +3 more
doaj   +1 more source

A pathwise approach to the extinction of branching processes with countably many types [PDF]

, 2019
We consider the extinction events of Galton-Watson processes with countably infinitely many types. In particular, we construct truncated and augmented Galton-Watson processes with finite but increasing sets of types.
Decrouez, G, Hautphenne, Sophie, Decrouez, Geoffrey, Braunsteins, Peter, Hautphenne, S, Braunsteins, P   +5 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Hemicellulose from mild extraction of biomass: Revealing structural insights and advancing potential value

Carbohydrate Polymer Technologies and Applications
Hemicellulose is one of the main components of biomass, though often overlooked in technical applications. Its valorization depends on the properties of this natural carbohydrate polymer, which are defined by the type of biomass, and structural changes ...
Rui Xu, Nataliia Doskaliuk, Bo Pang, Jiayun Xu, Wenyang Xu, Chunlin Xu, Markus Antonietti, Svitlana Filonenko   +7 more
doaj   +1 more source

Sensitivity analysis of a branching process evolving on a network with application in epidemiology [PDF]

Journal of Complex Networks, 2015
17 pages (30 with SI), Journal of Complex Networks, Feb ...
Sophie Hautphenne, Gautier Krings, Jean-Charles Delvenne, Vincent D. Blondel   +3 more
openaire   +2 more sources

Continuous dependence of a class of superprocesses on branching parameters and applications [PDF]

, 1997
A general class of finite variance critical (ξ,ɸ,k)-superprocesses X in a Luzin space E with càdlàg right motion process ξ, regular local branching mechanism ɸ, and branching functional k of bounded characteristic are shown to continuously depend on (ɸ,k)
Dawson, Donald A., Fleischmann, Klaus, Leduc, Guillaume   +2 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Crystal Phase Ionic Liquids for Energy Applications: Heat Capacity Prediction via a Hybrid Group Contribution Approach

Molecules
In the selection and design of ionic liquids (ILs) for various applications, including heat transfer fluids, thermal energy storage materials, fuel cells, and solvents for chemical processes, heat capacity is a key thermodynamic property.
Moh’d Basel Shahin, Shehzad Liaqat, Paul Nancarrow, Sarah J. McCormack   +3 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source