Results 61 to 70 of about 351,690 (298)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Assessing Performative Competence in German ELF-Classrooms – The Task of Teachers and Learners

open access: yesSCENARIO: Journal for Performative Teaching, Learning, Research, 2017
When it comes to categorizing what pupils in a German English language classroom do when they are taking over roles and enacting scenes, a variety of terms is usually applied, e.g.
Bosenius, Petra
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Pembelajaran Drama dengan Metode Role Playing Berbasis Project Learning bagi Mahasiswa PBSI Universitas Tidar

open access: yesCaLLs: Journal of Culture, Arts, Literature, and Linguistics, 2019
The primary competence owned by the student when they choosing Indonesian language and literature education study programme on Tidar University is present the stage of drama.
Imam Baihaqi
doaj   +1 more source

Project-based Learning to Raise Students\u27 Speaking Ability: Its\u27 Effect and Implementation (a Mix Method Research in Speaking II Subject at Stain Ponorogo) [PDF]

open access: yes, 2015
This research tries to attempt to know the effect of Project-based learning toward speaking ability and its\u27 effective implementation. The design of the research sequential was designs in which data that are collected and examined in one stage inform ...
Rohmahwati, P. (Pryla)
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A Robot who could not dance: Generating performative presence among performer, text, and audience through exploring and performing stories by children

open access: yesSCENARIO: Journal for Performative Teaching, Learning, Research
A cyclic performance project enabled Australian tertiary drama students and primary school students to connect through stories written by children in hospital in the UK. University drama students undertook a semester of puppetry and created performances
Linda Lorenza, Persephone Sextou
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Using Drama Activities in an Oral Expression Class for Trainee English Language Teachers in a French University Setting (MEEF 1)

open access: yesLidil, 2015
This article describes in some detail the drama-based approach and activities used in an oral expression class taught by the author as part of the first semester of the Masters (MEEF 1) program at the Université Paris Est–Créteil.
Mark Gray
doaj   +1 more source

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