Results 41 to 50 of about 27,389 (291)

REGγ Suppresses Ferroptosis and Induces Drug Resistance by Degrading WDR6 in Chondrosarcoma

Advanced Science, EarlyView.
Here, we identified REGγ as a susceptibility factor in chondrosarcoma. Our study demonstrates that abnormally activated REGγ‐20S proteasome promotes chondrosarcoma development and progression. Further validation in animal models revealed that blocking REGγ function induced ferroptosis, suppressed malignant progression of chondrosarcoma, and uncovered a
Fanrong Liu, Shihui Shen, Dongxia Li, Peilin Shi, Jiaming Xu, Tongxin Lv, Yingying Du, Jingwei Zhang, Bo Yang, Hansen Chen, Zhuoya Peng, Wenjie Ren, Lu Zhang, Sheng Cheng, Tongjin Yin, Wencai Sheng, Lei Li, Juan Wu, Qingcheng Yang, Shuogui Xu, Wei Zheng   +20 more
wiley   +1 more source

Performing Location: Place and Applied Theatre

, 2016
As the twenty-first century moves towards its third decade, applied theatre is being shaped by contemporary economic and environmental concerns and is contributing to new conceptual paradigms that influence the ways in which socially engaged art is ...
Mackey, Sally
core   +1 more source

Targeting NSUN2‐Mediated m5C Modification Attenuates Chondrocyte Senescence and NLRP3 Activation in Osteoarthritis

Advanced Science, EarlyView.
NSUN2‐mediated m5C modification cooperates with ALYREF to stabilize and export IP3R3 mRNA, increasing IP3R3 expression and Ca2 + overload in chondrocytes. This signaling promotes mitochondrial dysfunction, NLRP3 inflammasome activation, and senescence, thereby accelerating osteoarthritis progression.
Guping Mao, Wei Li, Zhencan Lin, Zengfa Deng, Ming Li, Zongrui Jiang, Changzhao Li, Dianbo Long, Yan Kang   +8 more
wiley   +1 more source

'Magic mothers and wicked criminals': Exploring narrative and role in a drama programme with women prisoners [PDF]

, 2013
This article explores narrative and role as key elements of an applied theatre project with women in an Australian prison. The research story has arisen out of the first stages of data analysis from the project, where a range of sometimes conflicting ...
Woodland, Sarah
core   +1 more source

Crossing Disciplinary Boundaries and Extending Participation through Film and Applied Theatre Techniques: Reflecting on the Umzi ka Mama Oral Histories Project

African Journal of Inter-Multidisciplinary Studies
Scholarship on African women has progressed from mainly focusing on royal women, political struggle heroines, and activists to include more stories of domestic workers, farmers, mothers, and daughters. Over time, feminist oral historians gradually moved
Phemelo Hellemann
doaj   +1 more source

Innovations in Gastric Cancer Surgery During Early Minimally Invasive Era and Future Perspectives

Annals of Gastroenterological Surgery, EarlyView.
With continuing revelations in tumor biology and the emergence of artificial intelligence, new horizons for surgical innovation are opening. At the center of this transformative journey stands the innovative surgeon, driven by passion, guided by data, and steadfast in the commitment to patient safety and quality of life.
Reut El‐On, Young‐Woo Kim
wiley   +1 more source

The tyranny of emotional distance?: Emotion/al work and emotional labour in applied theatre projects

, 2019
Taking as its theoretical starting point Sheila Preston’s (2013) discussion of emotional labour and the applied theatre facilitator, we examine how emotional labour in the applied theatre space might manifest through the experiences of not only the ...
Lazaroo, Natalie, Izzaty Ishak, Ishak, Izzaty, Natalie Lazaroo   +3 more
core   +1 more source

Vernacular Futurism: How Persian Language Users Imagine AI

AI &Innovation, EarlyView.
ABSTRACT Public discourse about artificial intelligence increasingly unfolds through compressed forecasts, moral warnings, and everyday speculation circulating at platform speed. This study examines how Persian language users on X construct and contest AI futures, analyzing a corpus of 4741 posts collected between January 2023 and December 2025, with ...
Arthur Asa Berger, Ehsan Shahghasemi
wiley   +1 more source

Applied Drama for Education and Social Change in Nigeria

Critical Stages, 2021
One of the greatest means of communication for social action in Africa has been through drama. Applied drama explores unconventional means to enlighten and sensitize society, creating awareness and reaching out to society by enhancing critical thinking ...
Mnena Abuku
doaj  

The Insistence of Blackness and the Persistence of Antiblackness in Ireland

Australian Journal of Social Issues, EarlyView.
ABSTRACT This paper positions Ireland as a critical site for examining the insistence of blackness and an antiblackness created and sustained through Irish ethnonationalist imaginaries and exclusionary processes. Drawing on connected sociologies and Irish Black Studies, this enquiry argues that antiblackness in Ireland operates as a generational force,
Philomena Mullen
wiley   +1 more source