Results 161 to 170 of about 430,873 (249)

Tackling High Dimensionality in QSP: Guiding Model Order Reduction With Index Analysis. [PDF]

CPT Pharmacometrics Syst Pharmacol
Tillil J, Huisinga W, Knöchel J.
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

A hybrid framework of hesitant fuzzy soft sets and rough sets for uncertainty modelling. [PDF]

Sci Rep
Jahanvi, Nishad DK, Singh R, Khalid S.
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Delamotte approximation

, 2016
Summary: We solve the anharmonic potential with an approximate, non-perturbative method of B. Delamotte. The numerical problem is analyzed and the analytical solution is obtained in Jacobi elliptical functions. We show, that the Fourier expansion of \(Sd(u\| m)\) the Jacobi function is the Delamotte approximation.
openaire   +2 more sources

Successful Management of Infected Widely Dehisced Wound Using Progressive Tension Sutures: Case Report. [PDF]

Int Med Case Rep J
Asrat K, Fikadu T, Tesfai B, Mekonen S, Frezgi O.   +4 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Efficient EM Estimation for the Pogit Model via Polya-Gamma Augmentation. [PDF]

Entropy (Basel)
Gutiérrez I, Ramírez S, Jofré L.
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

On the Gaussian distribution of the Mann-Kendall tau in the case of autocorrelated data. [PDF]

PLoS One
Gamot T, Thibeau-Sutre N, Van Dooren TJM.   +2 more
europepmc   +1 more source