Safety of Perioperative Aprotinin Administration During Isolated Coronary Artery Bypass Graft Surgery: Insights From the ART (Arterial Revascularization Trial) [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018 BackgroundThere is still uncertainty about the safety of aprotinin for coronary artery bypass graft surgery. The ART (Arterial Revascularization Trial) was designed to compare survival after bilateral versus single internal thoracic artery grafting. Many
Umberto Benedetto +7 more
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Aprotinin may increase mortality in low and intermediate risk but not in high risk cardiac surgical patients compared to tranexamic acid and ε-aminocaproic acid -- a meta-analysis of randomised and observational trials of over 30.000 patients. [PDF]
PLoS ONE, 2013 BackgroundTo compare the effect of aprotinin with the effect of lysine analogues (tranexamic acid and ε-aminocaproic acid) on early mortality in three subgroups of patients: low, intermediate and high risk of cardiac surgery.Methods and findingsWe ...
Patrick Meybohm +3 more
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Inhibitory effects of aprotinin on influenza A and B viruses in vitro and in vivo
Scientific Reports, 2021 Influenza viruses cause significant morbidity and mortality worldwide. Long-term or frequent use of approved anti-influenza agents has resulted in drug-resistant strains, thereby necessitating the discovery of new drugs. In this study, we found aprotinin,
Eun-Jung Song +8 more
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Aprotinin Inhibits SARS-CoV-2 Replication
Cells, 2020 Severe acute respiratory syndrome virus 2 (SARS-CoV-2) is the cause of the current coronavirus disease 19 (COVID-19) pandemic. Protease inhibitors are under consideration as virus entry inhibitors that prevent the cleavage of the coronavirus spike (S ...
Denisa Bojkova +13 more
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Aprotinin in high-risk isolated coronary artery bypass graft patients: a 3-year propensity matched study [PDF]
Journal of Cardiothoracic SurgeryBackground Aprotinin, a serine protease inhibitor, has been used variably in cardiac surgery amidst ongoing debates about its safety following several previous studies.
Rishab Makam +5 more
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European Journal of Anaesthesiology, 2015 SCOPUS: re.j ; info:eu-repo/semantics ...
De Hert, Stefan +10 more
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Binding of sodium dodecyl sulfate to aprotinin and its effect on the aprotinin molecule.
Chemical and Pharmaceutical Bulletin, 1986 When the basic protease inhibitor aprotinin was treated with sodium dodecyl sulfate (SDS), it showed an increased apparent molecular weight upon SDS gel electrophoresis. The amount of SDS bound to aprotinin was much lower than that bound to aprotinin treated with SDS and mercaptoethanol (ME).
Tadahiro Shikimi
openalex +5 more sources
Procoagulant Action of Aprotinin
Anesthesia & Analgesia, 1996 G. J. Despotis +3 more
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TH Open, 2021 Background Aprotinin is a broad-acting serine protease inhibitor that has been clinically used to prevent blood loss during major surgical procedures including cardiac surgery and liver transplantation.
Ton Lisman +3 more
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Kidney & Blood Pressure ResearchIntroduction: SGLT2 inhibitors are used to reduce the risk of progression of chronic kidney disease (CKD). In patients with type 2 diabetes, they have been found to reduce extracellular volume.
Anja Schork +9 more
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