Results 91 to 100 of about 103,741 (231)
A personalizable platform featuring a multi‐zonal cardiac patch design at clinical scale enables precise customization of fiber architecture at micro‐ and macroscale via melt electrowriting. Distinct scaffold zones support cell alignment with mechanical force transfer and epicardial attachment.
Johannes Braig +31 more
wiley +1 more source
Background Co-cultures of endothelial cells with mesenchymal stem cells currently represent one of the most promising approaches in providing oxygen and nutrient supply for microvascular tissue engineering.
Severin Mühleder +9 more
doaj +1 more source
The novel serine protease PreR-Co promotes endothelium-independent vasorelaxation in rabbit aortic rings [PDF]
The effect of a novel enzyme (PreR-Co) that activates renal prorenin was studied on rabbit aortas with and without endothelium. It was tested 1) in the basal tone of nonstimulated or ANG II-sensitized rings or rings precontracted with norepinephrine (NE),
Coviello, Alfredo +5 more
core +1 more source
IL‐4/IL‐13/STAT6 signaling plays a crucial for the suppression of pro‐inflammation during acute pancreatitis and supports acinar cell regeneration but has only minor impact on fibrogenesis during chronic form of the disease. IL‐4/IL‐13 induce the expression of certain collagens directly in pancreatic fibroblasts via STAT6 activation, whereas ...
Hager ElSheikh +13 more
wiley +1 more source
Efficacy and safety of antifibrinolytic agents in spinal surgery: a network meta-analysis
. Background:. Significant blood loss is still one of the most frequent complications in spinal surgery, which often necessitates blood transfusion. Massive perioperative blood loss and blood transfusion can create additional risks. Aprotinin, tranexamic
Lei Yuan +7 more
doaj +1 more source
Translation inhibition by rocaglates is independent of eIF4E phosphorylation status [PDF]
Rocaglates are natural products that inhibit protein synthesis in eukaryotes and exhibit antineoplastic activity. In vitro biochemical assays, affinity chromatography experiments coupled with mass spectrometry analysis, and in vivo genetic screens have ...
Cencic, Regina +4 more
core +1 more source
The diagram of the mechanism of action by which UroA regulates RF. ABSTRACT The global prevalence and mortality rates associated with chronic kidney disease (CKD) have been on a continuous rise over recent decades. Renal fibrosis (RF) serves as a critical factor in the progression of CKD to end‐stage renal disease.
Xue Wu +8 more
wiley +1 more source
Divergent Inhibitor Susceptibility among Airway Lumen-Accessible Tryptic Proteases.
Tryptic serine proteases of bronchial epithelium regulate ion flux, barrier integrity, and allergic inflammation. Inhibition of some of these proteases is a strategy to improve mucociliary function in cystic fibrosis and asthmatic inflammation.
Shilpa Nimishakavi +3 more
doaj +1 more source
Imidazole alkaloids epiisopilosine and epiisopiloturine protect the liver against acetaminophen‐induced toxicity by reducing oxidative stress, suppressing inflammatory mediators, and restoring antioxidant defenses. These hepatoprotective effects are partially mediated by enhanced autophagy, indicating a key mechanistic pathway for the biological ...
Ana Patricia de Oliveira +19 more
wiley +1 more source
In cardiac surgery with cardiopulmonary bypass (CPB) is a common complication. The incidence of this complication in cardiac surgery patients is estimated at about 10%.
V. Yu. Medvedeva +3 more
doaj +1 more source

