Results 91 to 100 of about 44,465 (273)

Low dose aprotinin increases mortality and morbidity in coronary artery bypass surgery

Journal of Research in Medical Sciences, 2012
Background: The low dose aprotinin consistently reduces blood and transfusion requirement in adults during cardiac surgical procedures but its effectiveness in some ethnical groups were debated and controversy about its effect on mor-tality and morbidity
Feridoun Sabzi, Gholam Reza Moradi, Heidar Dadkhah, Alireza Poormotaabed, Samsam Dabiri   +4 more
doaj  

Allosteric modulation of protein kinase A in individuals affected by NLPD‐PKA, a neurodegenerative disease in which the PRKAR1B L50R variant is expressed

The FEBS Journal, EarlyView.
In healthy neurons, Protein kinase A (PKA) forms a tetrameric holoenzyme enabling precise allosteric regulation. We characterized a novel neurodegenerative disease, neuronal loss, and parkinsonism driven by PRKAR1B mutation (NLPD‐PKA), demonstrating disrupted holoenzyme assembly, reduced cooperativity, and increased catalytic subunit nuclear ...
Tal Benjamin‐Zukerman, Valeria Pane, Rania Safadi‐Safa, Meir Solomon, Varda Lev‐Ram, Mohammad Aboraya, Anwar Dakwar, Daniela Bertinetti, Andrew Hoy, Merel O. Mol, John van Swieten, Rodrigo Maillard, Friedrich W. Herberg, Ronit Ilouz   +13 more
wiley   +1 more source

Extracellular serine-proteinases isolated from Streptomyces alboniger: Partial characterization and effect of aprotinin on cellular structure

Memorias do Instituto Oswaldo Cruz, 1999
Streptomyces alboniger ATCC 12461 grown in brain heart infusion (BHI) medium produced two extracellular serine-proteinases, denoted SP I and SP II, which were purified by ammonium sulfate precipitation and aprotinin-agarose affinity chromatography.
Lopes Andréa, Coelho Rosalie RR, Meirelles Maria Nazareth L, Branquinha Marta Helena, Vermelho Alane Beatriz   +4 more
doaj  

Cadherin‐6 controls neuronal migration during mouse neocortical development via an integrin‐mediated pathway

The FEBS Journal, EarlyView.
Neuronal migration plays essential roles in the establishment of mammalian brains, and its impairment causes severe developmental abnormalities and behavioral and cognitive deficits. Here, we report that cadherin‐6 (CDH6), an unusual cadherin molecule containing an RGD integrin‐binding motif in the first extracellular domain, controls the motility of ...
Yuki Hirota, Rikaho Saito, Takao Honda, Hitomi Sano, Mayuko Hotta, Yukiko U. Inoue, Takayoshi Inoue, Kazunori Nakajima   +7 more
wiley   +1 more source

CHOICE OF THE TECHNIQUE FOR BLOOD LOSS REDUCTION IN THE RECONSTRUCTIVE ORAL SURGERY

Вестник анестезиологии и реаниматологии, 2018
Goal of the study: to define the most optimal technique for blood loss reduction during reconstructive surgeries in maxillofacilal area. Materials and methods.
A. Yu. Zaitsev, K. V. Dubrovin, V. A. Svetlov   +2 more
doaj   +1 more source

The effects of a plant proteinase inhibitor from Enterolobium contortisiliquum on human tumor cell lines [PDF]

, 2011
Supplementary to the efficient inhibition of trypsin, chymotrypsin, plasma kallikrein, and plasmin already described by the EcTI inhibitor from Enterolobium contortisiliquum, it also blocks human neutrophil elastase (K(iapp)=4.3 nM) and prevents phorbol ...
Bhoola K.D., Bjorklund M., Chao J.C., Dani R., Foekens J.A., Fritz H., Germanov E., Hildenbrand R., Kallakury B.V., Macedo M.L., Miyasaka M., Moll U.M., Ohkoshi M., Oliva M.L., Skrzydlewska E., Stanton H., Stearns M.   +16 more
core   +1 more source

Anatomical design and production of a novel three‐dimensional co‐culture system replicating the human flexor digitorum profundus enthesis

Journal of Anatomy, EarlyView.
Anatomical morphometrics have been used to design and manufacture models of the flexor digitorum profundus tendon to bone insertion in vitro. This innovative approach can be used to design models of other enthesis regions with anatomical and clinical applicability.
Jeremy W. Mortimer, Philippa A. Rust, Jennifer Z. Paxton   +2 more
wiley   +1 more source

Effect of human myoblasts on tenogenic progression in 2D and 3D culture models

Journal of Anatomy, EarlyView.
We investigated whether factors released from muscle derived myogenic cells enhance tenogenic progressions of human tendon derived cells using two‐dimensional (2D) culture model and a three‐dimensional (3D)‐engineered tendon construct culture model.
Yoshifumi Tsuchiya, Ching‐Yan Chloé Yeung, Rene B. Svensson, Michael Kjaer   +3 more
wiley   +1 more source

Tissue Perfusion and Biomarkers Assessment Following Root Coverage Procedures

Journal of Periodontal Research, EarlyView.
Gingival recessions treated with a collagen matrix loaded with rhPDGF showed significantly greater early tissue perfusion compared to sites treated without the growth factor. Early tissue perfusion outcomes were correlated to the amount of root coverage and gingival thickness gain at 6 months.
Lorenzo Tavelli, Tu Nguyen, Maria Vera Rodriguez, Leonardo Mancini, William V. Giannobile, Shayan Barootchi   +5 more
wiley   +1 more source