Results 91 to 100 of about 114,758 (340)

Protective effects of the antioxidant Ginkgo biloba extract and the protease inhibitor aprotinin against Leiurus quinquestriatus venom-induced tissue damage in rats

Journal of Venomous Animals and Toxins including Tropical Diseases, 2006
Oxidative stress and proteases have been implicated in several diseases and extensive evidence indicates that antioxidants and protease inhibitors help prevent organ functional damage. Leiurus quinquestriatus (LQQ) scorpion venom causes cellular injuries
A. J. Fatani, H. A. Al-Zuhair, H. I. Yaquob, A. A. Abdel-Fattah, M. I. El-Sayed, F. A. El-Sayed   +5 more
doaj   +1 more source

Effect of peri‐operative pharmacological interventions on postoperative delirium in patients having cardiac surgery: a systematic review and Bayesian network meta‐analysis

Anaesthesia, EarlyView.
Summary Introduction Postoperative delirium is a common complication following cardiac surgery. Despite its known impact on patient outcomes, effective preventative strategies remain elusive. We aimed to perform a comprehensive Bayesian network meta‐analysis of randomised controlled trials assessing the effect of pharmacological interventions on the ...
Ivo Queiroz, Lucas M. Barbosa, Mariano Gallo Ruelas, Beatriz Araújo, Maria L. R. Defante, Arthur H. Tavares, Cynthia Florencio de Mesquita, Tulio Pimentel, Beatriz Ximenes Mendes, Iuri Ferreira Felix, André Rivera, Rafael Oliva Morgado Ferreira, Helen M. de Oliveira, Bruno B. Righetto, Nathan J. Smischney, Guangyu Tong, Daqing Ma   +16 more
wiley   +1 more source

Aprotinina não influencia troponina I, NTproBNP e função renal em crianças operadas com circulação extracorpórea High-dose aprotinin does not affect troponin I, N-Terminal pro-B-type natriuretic peptid and renal function in children submitted to surgical correction with extracorporeal circulation

Brazilian Journal of Cardiovascular Surgery, 2009
OBJETIVO: Avaliar se o uso de aprotinina em altas doses hemostáticas pode influenciar as funções miocárdicas, renais e metabólicas em crianças operadas com circulação extracorpórea (CEC). MÉTODOS: Estudo prospectivo randomizado em crianças de 30 dias a 4
Cesar Augusto Ferreira, Walter Villela de Andrade Vicente, Paulo Roberto Barbosa Évora, Alfredo José Rodrigues, Jyrson Guilherme Klamt, Ana Paula de Carvalho Panzeri Carlotti, Fábio Carmona, Paulo Henrique Manso   +7 more
doaj   +1 more source

Blockade of T-cell activation by dithiocarbamates involves novel mechanisms of inhibition of nuclear factor of activated T cells. [PDF]

, 1997
Dithiocarbamates (DTCs) have recently been reported as powerful inhibitors of NF-kappaB activation in a number of cell types. Given the role of this transcription factor in the regulation of gene expression in the inflammatory response, NF-kappaB ...
Algarté M., Aramburu J., Baeuerle P. A., Baichwal V. R., Beals C. R., Beg A. A., Bessho R., Boise L. H., Burns G. F., Chuvpilo S. D., Cockerill P. N., Cockerill P. N., Cotter T. G., Crabtree G. R., Crabtree G. R., Durand D. B., Goldfeld A. E., Gómez del Arco P., Hibi M., Ho S. N., Ho S. N., Hodge M. R., Hoey T., Izquierdo M., Jain J., Jain J., Lee H. J., Liu J., Loh C., Los M., Luo C., Luo C., Luo C., Masuda E. S., Masuda E. S., Mauri N., McCaffrey P. G., Meyer M., Minden A., Muoz C., Muoz C., Nobel C. S. I., Northrop J. P., Prieschl E. E., Radler-Pohl A., Rao A., Reisinger E. C., Rooney J. W., Ruff V. A., Schenk H., Schreck R., Schreck R., Schreiber E., Schreiber S. L., Schulze-Osthoff K., Schulze-Osthoff K., Sen C. K., Shaw J. P., Shaw K. T., Shibasaki F., Spits H., Staal F. J. T., Szabo S. J., Sánchez-Mateos P., Timmerman L. A., Traenckner E.B., Truneh A., Van Antwerp D. J., Wang C., Weiss A., Wu M., Xanthoudakis S., Yano O.   +72 more
core   +3 more sources

Stabilisation of PRCP by deubiquitinase‐targeting chimera (DUBTAC) to replenish autophagy for ameliorating pathological cardiac hypertrophy

British Journal of Pharmacology, EarlyView.
Background and Purpose Autophagy is essential for cellular homeostasis, and its impairment contributes to cardiac hypertrophy. Modulating autophagy has shown potential in treating pathological hypertrophy. Prolylcarboxypeptidase (PRCP), a lysosomal enzyme that hydrolyzes angiotensin II to Ang1‐7, has an unclear role in cardiac autophagy and hypertrophy.
Fangchao Zhou, Jun Xia, Yingjuan Liu, Wenqi He, Hongyuan Zhang, Bernard D. Keavney, Min Zi, Binh Y. Nguyen, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Susanne S. Hille, Elizabeth J. Cartwright, Oliver J. Müller, Honglin Xu, Sam Butterworth, Xin Wang   +16 more
wiley   +1 more source

Fibrinolysis protease receptors promote activation of astrocytes to express pro-inflammatory cytokines. [PDF]

, 2019
BACKGROUND:Astrocytes contribute to the crosstalk that generates chronic neuro-inflammation in neurological diseases; however, compared with microglia, astrocytes respond to a more limited continuum of innate immune system stimulants.
Azmoon, Pardis, Banki, Michael A, Gonias, Steven L, Kounnas, Maria Z, Mantuano, Elisabetta, Marchese, Cinzia, Pontecorvi, Paola, Zalfa, Cristina, Zampieri, Carlotta   +8 more
core   +1 more source

The 5 ' untranslated region of protein kinase C delta directs translation by an internal ribosome entry segment that is most active in densely growing cells and during apoptosis. [PDF]

, 2002
Protein kinase Cdelta (PKCdelta) is a member of the PKC family of phospholipid-dependent serine/threonine kinases and is involved in cell proliferation, apoptosis, and differentiation.
Morrish, B.C., Rumsby, M.G.
core   +2 more sources

Effects of the P2RX4 antagonist BR11595 in a guinea pig model of chronic asthma

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Asthma is characterized by airway hyperresponsiveness (AHR), allergic inflammation, and airway remodelling. Although recent studies have shown that asthma pathophysiology involves P2X4 receptor activation, a potential link with chronic asthma remains to be explored.
Dan Li, Hoeke A. Baarsma, Melissa Mol‐van der Veen, Vicky Verschut, Kimberley S. Belfor, Tanja de Boer, Harm Maarsingh, Oliver Martin Fischer, Carolin Ebert, Hana Cernecka, Muriel Lizé, Reinoud Gosens, Loes Kistemaker, Martina Schmidt   +13 more
wiley   +1 more source

Avaliação da aprotinina na redução da resposta inflamatória sistêmica em crianças operadas com circulação extracorpórea Assessment of aprotinin in the reduction of inflammatory systemic response in children undergoing surgery with cardiopulmonary bypass

Brazilian Journal of Cardiovascular Surgery, 2010
OBJETIVO: Avaliar se a aprotinina em altas doses hemostáticas pode reduzir o processo inflamatório após circulação extracorpórea (CEC) em crianças. MÉTODOS: Estudo prospectivo randomizado em crianças de 30 dias a 4 anos de idade, submetidas à correção de
Cesar Augusto Ferreira, Walter Villela de Andrade Vicente, Paulo Roberto Barbosa Evora, Alfredo José Rodrigues, Jyrson Guilherme Klamt, Ana Paula de Carvalho Panzeli Carlotti, Fábio Carmona, Paulo Henrique Manso   +7 more
doaj   +1 more source

Exploiting PP2A dependent and independent effects of forskolin for therapeutic targeting of KMT2A (MLL)‐rearranged acute leukaemia

British Journal of Pharmacology, EarlyView.
Background and Purpose Activation of Protein Phosphatase 2A (PP2A), via genetic and pharmacologic modulation of SET, has recently being identified as a promising strategy to therapeutically target acute myeloid leukaemia (AML) carrying KMT2A (MLL) chromosomal translocations (KMT2A‐r AML).
Yoana Arroyo‐Berdugo, Antonella Di Mambro, Volker Behrends, Michelle A. Sahai, Luca Cozzuto, Immacolata Zollo, Julia Ponomarenko, Owen Williams, John Gribben, Yolanda Calle, Bela Patel, Maria Teresa Esposito   +11 more
wiley   +1 more source