Results 91 to 100 of about 103,741 (231)

From Fiber Architecture to Functional Attachment: A Clinically Relevant, Mechanically Tunable Cardiac Patch

open access: yesAdvanced Materials, Volume 38, Issue 17, 20 March 2026.
A personalizable platform featuring a multi‐zonal cardiac patch design at clinical scale enables precise customization of fiber architecture at micro‐ and macroscale via melt electrowriting. Distinct scaffold zones support cell alignment with mechanical force transfer and epicardial attachment.
Johannes Braig   +31 more
wiley   +1 more source

The role of fibrinolysis inhibition in engineered vascular networks derived from endothelial cells and adipose-derived stem cells

open access: yesStem Cell Research & Therapy, 2018
Background Co-cultures of endothelial cells with mesenchymal stem cells currently represent one of the most promising approaches in providing oxygen and nutrient supply for microvascular tissue engineering.
Severin Mühleder   +9 more
doaj   +1 more source

The novel serine protease PreR-Co promotes endothelium-independent vasorelaxation in rabbit aortic rings [PDF]

open access: yes, 2003
The effect of a novel enzyme (PreR-Co) that activates renal prorenin was studied on rabbit aortas with and without endothelium. It was tested 1) in the basal tone of nonstimulated or ANG II-sensitized rings or rings precontracted with norepinephrine (NE),
Coviello, Alfredo   +5 more
core   +1 more source

IL‐4/STAT6‐signaling Influences Local Inflammation and Regeneration Processes During Acute Pancreatitis and Promotes Fibrosis by a Direct Activation of Pancreatic Fibroblasts During Chronic Pancreatitis

open access: yesAdvanced Science, Volume 13, Issue 14, 9 March 2026.
IL‐4/IL‐13/STAT6 signaling plays a crucial for the suppression of pro‐inflammation during acute pancreatitis and supports acinar cell regeneration but has only minor impact on fibrogenesis during chronic form of the disease. IL‐4/IL‐13 induce the expression of certain collagens directly in pancreatic fibroblasts via STAT6 activation, whereas ...
Hager ElSheikh   +13 more
wiley   +1 more source

Efficacy and safety of antifibrinolytic agents in spinal surgery: a network meta-analysis

open access: yesChinese Medical Journal, 2019
. Background:. Significant blood loss is still one of the most frequent complications in spinal surgery, which often necessitates blood transfusion. Massive perioperative blood loss and blood transfusion can create additional risks. Aprotinin, tranexamic
Lei Yuan   +7 more
doaj   +1 more source

Translation inhibition by rocaglates is independent of eIF4E phosphorylation status [PDF]

open access: yes, 2016
Rocaglates are natural products that inhibit protein synthesis in eukaryotes and exhibit antineoplastic activity. In vitro biochemical assays, affinity chromatography experiments coupled with mass spectrometry analysis, and in vivo genetic screens have ...
Cencic, Regina   +4 more
core   +1 more source

Targeting the Nrf2/TGF‐β1/Smad Signaling Pathway: A Novel Strategy for Urolithin A to Alleviate Renal Fibrosis

open access: yesFood Frontiers, Volume 7, Issue 2, March 2026.
The diagram of the mechanism of action by which UroA regulates RF. ABSTRACT The global prevalence and mortality rates associated with chronic kidney disease (CKD) have been on a continuous rise over recent decades. Renal fibrosis (RF) serves as a critical factor in the progression of CKD to end‐stage renal disease.
Xue Wu   +8 more
wiley   +1 more source

Divergent Inhibitor Susceptibility among Airway Lumen-Accessible Tryptic Proteases.

open access: yesPLoS ONE, 2015
Tryptic serine proteases of bronchial epithelium regulate ion flux, barrier integrity, and allergic inflammation. Inhibition of some of these proteases is a strategy to improve mucociliary function in cystic fibrosis and asthmatic inflammation.
Shilpa Nimishakavi   +3 more
doaj   +1 more source

Imidazole Alkaloids Epiisopilosine and Epiisopiloturine Attenuate Acetaminophen‐Induced Liver Toxicity in Mice via Autophagy Modulation and Anti‐Inflammatory Effects

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 40, Issue 3, March 2026.
Imidazole alkaloids epiisopilosine and epiisopiloturine protect the liver against acetaminophen‐induced toxicity by reducing oxidative stress, suppressing inflammatory mediators, and restoring antioxidant defenses. These hepatoprotective effects are partially mediated by enhanced autophagy, indicating a key mechanistic pathway for the biological ...
Ana Patricia de Oliveira   +19 more
wiley   +1 more source

The use of fibrinolysis inhibitors in cardiac surgery with cardiopulmonary bypass (literature review)

open access: yesВестник анестезиологии и реаниматологии
In cardiac surgery with cardiopulmonary bypass (CPB) is a common complication. The incidence of this complication in cardiac surgery patients is estimated at about 10%.
V. Yu. Medvedeva   +3 more
doaj   +1 more source

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