Results 11 to 20 of about 114,758 (340)

Aprotinin: is it time to reconsider?

European Journal of Anaesthesiology, 2015
SCOPUS: re.j ; info:eu-repo/semantics ...
S. Hert, Ravi Gill, W. Habre, Marcus Lance, J. V. Llau, Jens Meier, Philippe Pouard, C. Samama, Jan van der Linden, Philippe Van der Linden, Christian von Heyman   +10 more
semanticscholar   +6 more sources

Binding of sodium dodecyl sulfate to aprotinin and its effect on the aprotinin molecule.

Chemical and Pharmaceutical Bulletin, 1986
When the basic protease inhibitor aprotinin was treated with sodium dodecyl sulfate (SDS), it showed an increased apparent molecular weight upon SDS gel electrophoresis. The amount of SDS bound to aprotinin was much lower than that bound to aprotinin treated with SDS and mercaptoethanol (ME).
Tadahiro Shikimi
openalex   +5 more sources

Aprotinin revisited [PDF]

The Journal of Thoracic and Cardiovascular Surgery, 2012
In 2008, we saw the withdrawal of aprotinin from the US markets after preliminary results from a large, randomized clinical trial in Canada. This drug, a potent antifibrinolytic, was used primarily in complex and/or redo cardiac surgery as an adjunct to decrease postoperative bleeding and complications.
DeAnda, Abe, Spiess, Bruce D.
openaire   +2 more sources

Aprotinin in orthotopic liver transplantation [PDF]

Seminars in Thrombosis and Hemostasis, 1993
Aprotinin is a protease inhibitor isolated from bovine lungs and othcr lissues. Its biochcmical struc!Urc, a single-chain polypeptide of 6.5 12 kD , and biophysical properties are weH defined. I The activity of commcrcial preparations of apralini n is usually describcd in kallikrein inac ti valor unils (KIU) , 0. 1 million KIU being equivalent 102.
Bechstein, W. O., Blumhardt, G., Gerlach, H., Himmelreich, G., Jochum, Marianne, Keck, H., Neuhaus, P., Riess, H., Roissaint, R.   +8 more
core   +4 more sources

Aprotinin and cardiac surgery. [PDF]

BMJ, 1991
Beverley J. Hunt, Magdi Yacoub
openalex   +4 more sources

Procoagulant Action of Aprotinin

Anesthesia & Analgesia, 1996
G. J. Despotis, A. Alsoufiev, L. T. Goodnough, D. G. Lappas   +3 more
  +7 more sources

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

Hepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodríguez, Luis Leiva‐Vega, Aránzazu Pintor‐Chocano, Daniel Horrillo, Lourdes Hernández‐Cosido, Jorge L. Torres, Eva Novoa, Rubén Nogueiras, Gema Medina‐Gómez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio   +14 more
wiley   +1 more source

Aprotinin reduces cardiac troponin I release and inhibits apoptosis of polymorphonuclear cells during off-pump coronary artery bypass surgery [PDF]

, 2008
Objectives: In addition to blood-sparing effects, aprotinin may have cardioprotective and anti-inflammatory effects during cardiopulmonary bypass-assisted cardiac surgery.
Bert, C., Ceuppens, J., De Buck, F., Delforge, M., Kasran, A., Meyns, B., Sergeant, P., Van Duppen, V., Van Hemelrijck, J., Wouters, Patrick   +9 more
core   +2 more sources

The degradation of gelatin/alginate/fibrin hydrogels is cell type dependent and can be modulated by targeting fibrinolysis

Frontiers in Bioengineering and Biotechnology, 2022
In tissue engineering, cell origin is important to ensure outcome quality. However, the impact of the cell type chosen for seeding in a biocompatible matrix has been less investigated.
Elea Boucard, Luciano Vidal, Flora Coulon, Carlos Mota, Jean-Yves Hascoët, Franck Halary   +5 more
doaj   +1 more source

The safety and efficacy of antifibrinolytic therapy in neonatal cardiac surgery. [PDF]

PLoS ONE, 2015
Neonates undergoing open-heart surgery are particularly at risk of postoperative bleeding requiring blood transfusion. Aprotinin has attained high efficacy in reducing the requirement for a blood transfusion following a cardiopulmonary bypass, but is ...
Chih-Yuan Lin, Jeffery H Shuhaiber, Hugo Loyola, Hua Liu, Pedro Del Nido, James A DiNardo, Frank A Pigula   +6 more
doaj   +1 more source