Aprotinin inhibits proinflammatory activation of endothelial cells by thrombin through the protease-activated receptor 1 [PDF]
, 2006 ObjectiveThrombin is generated in significant quantities during cardiopulmonary bypass and mediates adverse events, such as platelet aggregation and proinflammatory responses, through activation of the high-affinity thrombin receptor protease-activated ...
Day, Jonathan R.S. +6 more
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Influence of high-dose aprotinin treatment on blood loss and coagulation patterns in open-heart surgery [PDF]
, 1990 Intraoperative administration of the proteinase Inhibitor aprotinin causes reduction in blood loss and homologous blood requirement in patients undergoing cardiac surgery.
Baranky, A. +6 more
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Effect of aprotinin on immunological resistance in tumour-bearing animals. [PDF]
, 1976 Previous studies suggested that aprotinin might enhance the host's immunological resistance to tumours. This possibility has now been further investigated by studying the behaviour of tumours in both hamsters and mice.
Latner, A. L., Turner, G. A.
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Dextran sulfate activates contact system and mediates arterial hypotension via B2 kinin receptors [PDF]
, 1994 To define some of the mechanisms underlying dextran sulfate (DXS)-induced hypotension, we investigated the effects of either the plasma kallikrein inhibitor des-Pro2-[Arg15] aprotinin (BAY x 4620) or the specific bradykinin B2-receptor antagonist Hoe-140
Cheronis, John C. +7 more
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Aprotinin and major orthopedic surgery [PDF]
Transfusion Alternatives in Transfusion Medicine, 2004 SUMMARYAprotinin is a potent pharmacological agent which reduces bleeding and limits blood transfusion in current surgical practice. Many studies have been conducted in orthopedic surgery. Several trials have been performed in total hip replacement and total knee replacement patients, and aprotinin only moderately decreased blood loss requirements in ...
openaire +4 more sources
Cleavage of endogenous gamma ENaC and elevated abundance of alpha ENaC are associated with increased Na+ transport in response to apical fluid volume expansion in human H441 airway epithelial cells [PDF]
, 2011 Using human H441 airway epithelial cells cultured at air–liquid interface (ALI), we have uniquely correlated the functional response to apical fluid volume expansion with the abundance and cleavage of endogenous α- and γENaC proteins in the apical ...
Baines, DL, Selvanathar, IA, Tan, CD
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Is There a Surgical Role for Topical Aprotinin? [PDF]
Anesthesiology, 2008 To the Editor:—Two classes of intravenous drugs are commonly used in the perioperative setting to mitigate bleeding after cardiac surgery: lysine analogs (e.g., aminocaproic acid, tranexamic acid) and serine protease inhibitors (e.g., aprotinin).
Charles D. Collard +2 more
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Different aprotinin applications influencing hemostatic chances in orthotopic liver transplantation [PDF]
, 1992 The effect of different aprotinin applications on hemmtatic changes and blood product requirements in orthotopic liver transplantation was investigated in a prospective, open, and randomized study.
Bechstein, W. O. +6 more
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Are antifibrinolytic drugs equivalent in reducing blood loss and transfusion in cardiac surgery? A meta-analysis of randomized head-to-head trials [PDF]
, 2005 BACKGROUND: Aprotinin has been shown to be effective in reducing peri-operative blood loss and the need for re-operation due to continued bleeding in cardiac surgery.
A Laupacis +43 more
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Aprotinin in severe acute pancreatitis
International Journal of Clinical Practice, 2010 Aprotinin, a Kunitz protease inhibitor, has a wide inhibitory action with particular activity against trypsin, chymotrypsin and kallikrein, making it theoretically attractive in ameliorating the effects of acute pancreatitis. Its use in acute pancreatitis has been studied for the last 50 years with disappointing results.
Beverley J. Hunt +2 more
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