Results 21 to 30 of about 110,212 (273)

Modulation of thromboinflammation in hospitalized COVID‐19 patients with aprotinin, low molecular weight heparin, and anakinra: The DAWn‐Antico study

Research and Practice in Thrombosis and Haemostasis, 2022
Background Thromboinflammation plays a central role in severe COVID‐19. The kallikrein pathway activates both inflammatory pathways and contact‐mediated coagulation.
Matthias M. Engelen, Quentin Van Thillo, Albrecht Betrains, Iwein Gyselinck, Caroline P. Martens, Valérie Spalart, Anna Ockerman, Caroline Devooght, Joost Wauters, Jan Gunst, Carine Wouters, Christophe Vandenbriele, Steffen Rex, Laurens Liesenborghs, Alexander Wilmer, Philippe Meersseman, Greet Van den Berghe, Dieter Dauwe, Ann Belmans, Michiel Thomeer, Tom Fivez, Dieter Mesotten, David Ruttens, Luc Heytens, Ilse Dapper, Sebastiaan Tuyls, Brecht De Tavernier, Peter Verhamme, Thomas Vanassche, DAWn Consortium Members   +29 more
doaj   +1 more source

Influence of ultra-low dose Aprotinin on thoracic surgical operations: a prospective randomized trial

Journal of Cardiothoracic Surgery, 2008
Background The blood saving effect of aprotinin has been well documented in cardiac surgery. In thoracic surgery, very few recent studies, using rather high doses of aprotinin, have shown a similar result.
Sourgiadaki Efrosini, Stamou-Kouki Helen, Crockett James, Koletsis Efstratios N, Panagopoulos Nikolaos, Apostolakis Efstratios, Filos Kriton, Dougenis Dimitrios   +7 more
doaj   +1 more source

The Efficacy of Aprotinin Combinations with Selected Antiviral Drugs in Mouse Models of Influenza Pneumonia and Coronavirus Infection Caused by SARS-CoV-2

Molecules, 2022
The efficacy of aprotinin combinations with selected antiviral-drugs treatment of influenza virus and coronavirus (SARS-CoV-2) infection was studied in mice models of influenza pneumonia and COVID-19.
Andrey A. Ivashchenko, Bogdan A. Zagribelnyy, Yan A. Ivanenkov, Ilya A. Ivashchenko, Ruben N. Karapetian, Dmitry V. Kravchenko, Nikolay P. Savchuk, Elena V. Yakubova, Alexandre V. Ivachtchenko   +8 more
doaj   +1 more source

Plasmin inhibitors prevent leukocyte accumulation and remodeling events in the postischemic microvasculature. [PDF]

PLoS ONE, 2011
Clinical trials revealed beneficial effects of the broad-spectrum serine protease inhibitor aprotinin on the prevention of ischemia-reperfusion (I/R) injury. The underlying mechanisms remained largely unclear.
Christoph A Reichel, Max Lerchenberger, Bernd Uhl, Markus Rehberg, Nina Berberich, Stefan Zahler, Matthias P Wymann, Fritz Krombach   +7 more
doaj   +1 more source

The possibilities of using the inhibitors of matrix metalloproteinases for keratoplasty

Трансплантология (Москва), 2023
Introduction. The review is devoted to the actual problem of treating patients with keratolysis. The role of matrix metalloproteinases in the pathogenesis of cornea and corneal graft melting is discussed as well as the practical experience of using ...
K. V. Sirotkina, E. V. Chentsova
doaj   +1 more source

Inhibition of Plasma Kallikrein with Aprotinin in porcine endotoxin Shock [PDF]

, 1993
Activation of the contact phase of coagulation has been implicated in the pathogenesis of septic shock. We wanted to determine if inhibition of plasma kallikrein can prevent arterial hypotension and liberation of kinins from kininogen, induced by an ...
Fink, Edwin, Fritz, Hans, Jochum, Marianne, Kroworsch, Peter, Schweiberer, Leonhard, Shimamoto, Kazuaki, Siebeck, Matthias, Spannagl, Michael, Weipert, Joachim   +8 more
core   +1 more source

Aprotinin and classic wound drainage are unnecessary in total hip replacement a prospective randomized trial

European Journal of Medical Research, 2011
Background Classic wound drainage is still common in hip replacement but its benefit is doubtful. The role of systemic administration of proteinase inhibitors like aprotinin to avoid perioperative blood loss is still unclear.
Fleischmann F, Matuschek C, Orth K, Gerber PA, Mota R, Knoefel WT, Peiper M, Schick M, van Griensven M, Bdlke E, Fleischmann W   +10 more
doaj   +1 more source

Antifibrinolytics and cardiac surgery: The past, the present, and the future

Annals of Cardiac Anaesthesia, 2020
Cardiac surgery is usually associated with significant blood loss, which often necessitates blood transfusion. In order to decrease the risks associated with the latter, pharmacological as well as nonpharmacological strategies have been used to reduce ...
Naresh K Aggarwal, Arun Subramanian
doaj   +1 more source

HGF modulates actin cytoskeleton remodeling and contraction in testicular myoid cells [PDF]

, 2015
The presence of the HGF/Met system in the testicular myoid cells was first discovered by our group. However, the physiological role of this pathway remains poorly understood. We previously reported that HGF increases uPA secretion and TGF-β activation in
Angela, Catizone, Caruso, Maria, Galdieri, Michela, Ricci, Giulia, Rita, Canipari, Scheri, Katia Corano, Virginia, Di Paolo   +6 more
core   +1 more source

Antifibrinolytics in cardiac surgery

Annals of Cardiac Anaesthesia, 2013
Cardiac surgery exerts a significant strain on the blood bank services and is a model example in which a multi-modal blood-conservation strategy is recommended.
Achal Dhir
doaj   +1 more source