Results 21 to 30 of about 44,424 (232)
Role of Aprotinin in Moderate and Severe Burns
Indian Journal of Plastic Surgery, 1987 The role of Aprotinin (Antagosan) in moderate and severe thermal burns has been studied. Patients were randomized in two groups; both receiving same treatment with the exception that patients in trial group received Aprotinin in addition. 2000,000 K.I.U.
Prateek Bhatnagar +2 more
doaj +1 more source
Topical use of antifibrinolytic agents reduces postoperative bleeding: a double-blind, prospective, randomized study [PDF]
, 2007 Objective: Postoperative bleeding is still one of the most common complications of cardiac surgery. Antifibrinolytic agents successfully reduce bleeding, but there are controversies concerning adverse effects after their systemic use.
Barić, Davor +7 more
core +1 more source
Anti-neoplastic effects of aprotinin on human breast cancer cell lines: In vitro study.
Advances in Clinical and Experimental Medicine, 2019 BACKGROUND Aprotinin is a nonspecific serine protease inhibitor, which can inhibit plasminogen-plasmin system and matrix metalloproteinases. Aprotinin has been investigated as an antitumor agent.
Saeed Soleyman-jahi +7 more
semanticscholar +1 more source
Effect of Aprotinin and Avifavir® Combination Therapy for Moderate COVID-19 Patients
Viruses, 2021 COVID-19 is a contagious multisystem inflammatory disease caused by a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We studied the efficacy of Aprotinin (nonspecific serine proteases inhibitor) in combination with Avifavir® or ...
Andrey A. Ivashchenko +14 more
doaj +1 more source
Inhibition of Plasma Kallikrein with Aprotinin in porcine endotoxin Shock [PDF]
, 1993 Activation of the contact phase of coagulation has been implicated in the pathogenesis of septic shock. We wanted to determine if inhibition of plasma kallikrein can prevent arterial hypotension and liberation of kinins from kininogen, induced by an ...
Fink, Edwin +8 more
core +1 more source
Journal of Cardiothoracic Surgery, 2008 Background The blood saving effect of aprotinin has been well documented in cardiac surgery. In thoracic surgery, very few recent studies, using rather high doses of aprotinin, have shown a similar result.
Sourgiadaki Efrosini +7 more
doaj +1 more source
A comparison of aprotinin and lysine analogues in high-risk cardiac surgery.
New England Journal of Medicine, 2008 BACKGROUND Antifibrinolytic agents are commonly used during cardiac surgery to minimize bleeding and to reduce exposure to blood products. We sought to determine whether aprotinin was superior to either tranexamic acid or aminocaproic acid in decreasing ...
D. Fergusson +18 more
semanticscholar +1 more source
BMC Cardiovascular Disorders, 2005 Background Aprotinin has been shown to be effective in reducing peri-operative blood loss and the need for re-operation due to continued bleeding in cardiac surgery.
Stokes Barrie J +3 more
doaj +1 more source
The risk associated with aprotinin in cardiac surgery.
New England Journal of Medicine, 2006 BACKGROUND The majority of patients undergoing surgical treatment for ST-elevation myocardial infarction receive antifibrinolytic therapy to limit blood loss. This approach appears counterintuitive to the accepted medical treatment of the same condition--
D. Mangano, I. C. Tudor, Cynthia Dietzel
semanticscholar +1 more source
Impact of aprotinin and renal function on mortality: a retrospective single center analysis
Journal of Cardiothoracic Surgery, 2011 Background An estimated up to 7% of high-risk cardiac surgery patients return to the operating room for bleeding. Aprotinin was used extensively as an antifibrinolytic agent in cardiac surgery patients for over 15 years and it showed efficacy in reducing
Von Visger Jon +6 more
doaj +1 more source