Results 21 to 30 of about 114,758 (340)

Intraoperative anaphylaxis due to aprotinin after local application of fibrin sealant diagnosed by skin tests and basophil activation tests: a case report

JA Clinical Reports, 2021
Background There are few cases of anaphylaxis after local application of fibrin sealant diagnosed by skin tests. Case presentation A 49-year-old woman underwent partial lung resection under general anesthesia. Anesthesia was induced uneventfully. Shortly
Masaki Orihara, Tomonori Takazawa, Tatsuo Horiuchi, Shinya Sakamoto, Mutsumi Uchiyama, Shigeru Saito   +5 more
doaj   +1 more source

Topical use of antifibrinolytic agents reduces postoperative bleeding: a double-blind, prospective, randomized study [PDF]

, 2007
Objective: Postoperative bleeding is still one of the most common complications of cardiac surgery. Antifibrinolytic agents successfully reduce bleeding, but there are controversies concerning adverse effects after their systemic use.
Barić, Davor, Bačić Vrca, Vesna, Biočina, Bojan, Brkić, Kristina, Ivković, Mira, Rudež, Igor, Sutlić, Željko, Unić, Daniel   +7 more
core   +1 more source

Role of Aprotinin in Moderate and Severe Burns

Indian Journal of Plastic Surgery, 1987
The role of Aprotinin (Antagosan) in moderate and severe thermal burns has been studied. Patients were randomized in two groups; both receiving same treatment with the exception that patients in trial group received Aprotinin in addition. 2000,000 K.I.U.
Prateek Bhatnagar, A. K. Singh, Tarachand Tarachand   +2 more
doaj   +1 more source

Aprotinin interacts with substrate-binding site of human dipeptidyl peptidase III

Journal of Biomolecular Structure and Dynamics, 2019
Human dipeptidyl peptidase III (hDPP III) is a zinc-exopeptidase of the family M49 involved in final steps of intracellular protein degradation and in cytoprotective pathway Keap1-Nrf2.
D. Agić, H. Brkić, Saša Kazazić, A. Tomić, M. Abramić   +4 more
semanticscholar   +1 more source

Anti-neoplastic effects of aprotinin on human breast cancer cell lines: In vitro study.

Advances in Clinical and Experimental Medicine, 2019
BACKGROUND Aprotinin is a nonspecific serine protease inhibitor, which can inhibit plasminogen-plasmin system and matrix metalloproteinases. Aprotinin has been investigated as an antitumor agent.
Saeed Soleyman-jahi, F. Sadeghi, Z. Afshari, Tahereh Barati, Sevil Ghasemi, S. Muhammadnejad, S. Amanpour, K. Zendehdel   +7 more
semanticscholar   +1 more source

Preservation of renal endothelial integrity and reduction of renal edema by aprotinin does not preserve renal perfusion and function following experimental cardiopulmonary bypass

Intensive Care Medicine Experimental, 2021
Background Acute kidney injury is a severe complication following cardiopulmonary bypass (CPB) and is associated with capillary leakage and microcirculatory perfusion disturbances.
Nicole A. M. Dekker, Anoek L. I. van Leeuwen, Matijs van Meurs, Jill Moser, Jeannette E. Pankras, Nicole N. van der Wel, Hans W. Niessen, Marc G. Vervloet, Alexander B. A. Vonk, Peter L. Hordijk, Christa Boer, Charissa E. van den Brom   +11 more
doaj   +1 more source

Are antifibrinolytic drugs equivalent in reducing blood loss and transfusion in cardiac surgery? A meta-analysis of randomized head-to-head trials

BMC Cardiovascular Disorders, 2005
Background Aprotinin has been shown to be effective in reducing peri-operative blood loss and the need for re-operation due to continued bleeding in cardiac surgery.
Stokes Barrie J, Moxey Annette J, Carless Paul A, Henry David A   +3 more
doaj   +1 more source

Effect of Aprotinin and Avifavir^® Combination Therapy for Moderate COVID-19 Patients

Viruses, 2021
COVID-19 is a contagious multisystem inflammatory disease caused by a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We studied the efficacy of Aprotinin (nonspecific serine proteases inhibitor) in combination with Avifavir® or ...
Andrey A. Ivashchenko, Valeria N. Azarova, Alina N. Egorova, Ruben N. Karapetian, Dmitry V. Kravchenko, Natalia V. Krivonos, Vladimir G. Loginov, Stanislav V. Poyarkov, Elena A. Merkulova, Olga S. Rosinkova, Nikolay P. Savchuk, Mikhail A. Topr, Elena N. Simakina, Elena V. Yakubova, Alexandre V. Ivachtchenko   +14 more
doaj   +1 more source

Impact of aprotinin and renal function on mortality: a retrospective single center analysis

Journal of Cardiothoracic Surgery, 2011
Background An estimated up to 7% of high-risk cardiac surgery patients return to the operating room for bleeding. Aprotinin was used extensively as an antifibrinolytic agent in cardiac surgery patients for over 15 years and it showed efficacy in reducing
Von Visger Jon, O'Brien William, Abdel-Rasoul Mahmoud, Yu Lianbo, Gulati Parul, Schloss Brian, Awad Hamdy   +6 more
doaj   +1 more source

Identification of an aprotinin antiviral domain [PDF]

FEBS Letters, 1994
Digestion of the proteinase inhibitor aprotinin, by clostripain, a cysteine proteinase, yielded five oligopeptide fragments. Two fragments exhibited both antiviral and antibacterial activities, two fragments only antiviral activity, and one fragment showed no antimicrobial activity.
Marco Franchini, Martina Stöckli, Roland von Fellenberg, Peter Hunziker, Antonio Pellegrini, Ursula Thomas, Stefan Klauser   +6 more
openaire   +3 more sources