Results 31 to 40 of about 44,465 (273)

Aprotinin interacts with substrate-binding site of human dipeptidyl peptidase III

Journal of Biomolecular Structure and Dynamics, 2019
Human dipeptidyl peptidase III (hDPP III) is a zinc-exopeptidase of the family M49 involved in final steps of intracellular protein degradation and in cytoprotective pathway Keap1-Nrf2.
D. Agić, H. Brkić, Saša Kazazić, A. Tomić, M. Abramić   +4 more
semanticscholar   +1 more source

Modulation of thromboinflammation in hospitalized COVID‐19 patients with aprotinin, low molecular weight heparin, and anakinra: The DAWn‐Antico study

Research and Practice in Thrombosis and Haemostasis, 2022
Background Thromboinflammation plays a central role in severe COVID‐19. The kallikrein pathway activates both inflammatory pathways and contact‐mediated coagulation.
Matthias M. Engelen, Quentin Van Thillo, Albrecht Betrains, Iwein Gyselinck, Caroline P. Martens, Valérie Spalart, Anna Ockerman, Caroline Devooght, Joost Wauters, Jan Gunst, Carine Wouters, Christophe Vandenbriele, Steffen Rex, Laurens Liesenborghs, Alexander Wilmer, Philippe Meersseman, Greet Van den Berghe, Dieter Dauwe, Ann Belmans, Michiel Thomeer, Tom Fivez, Dieter Mesotten, David Ruttens, Luc Heytens, Ilse Dapper, Sebastiaan Tuyls, Brecht De Tavernier, Peter Verhamme, Thomas Vanassche, DAWn Consortium Members   +29 more
doaj   +1 more source

Aprotinin extends mechanical integrity time of cell-seeded fibrin sutures.

Journal of Biomedical Materials Research. Part A, 2016
Cell therapy has the potential to treat different pathologies, including myocardial infarctions (heart attacks), although cell engraftment remains elusive with most delivery methods.
Spencer Coffin, G. Gaudette
semanticscholar   +1 more source

Identification of an aprotinin antiviral domain [PDF]

FEBS Letters, 1994
Digestion of the proteinase inhibitor aprotinin, by clostripain, a cysteine proteinase, yielded five oligopeptide fragments. Two fragments exhibited both antiviral and antibacterial activities, two fragments only antiviral activity, and one fragment showed no antimicrobial activity.
Marco Franchini, Martina Stöckli, Roland von Fellenberg, Peter Hunziker, Antonio Pellegrini, Ursula Thomas, Stefan Klauser   +6 more
openaire   +3 more sources

Antifibrinolytics and cardiac surgery: The past, the present, and the future

Annals of Cardiac Anaesthesia, 2020
Cardiac surgery is usually associated with significant blood loss, which often necessitates blood transfusion. In order to decrease the risks associated with the latter, pharmacological as well as nonpharmacological strategies have been used to reduce ...
Naresh K Aggarwal, Arun Subramanian
doaj   +1 more source

Plasmin inhibitors prevent leukocyte accumulation and remodeling events in the postischemic microvasculature. [PDF]

PLoS ONE, 2011
Clinical trials revealed beneficial effects of the broad-spectrum serine protease inhibitor aprotinin on the prevention of ischemia-reperfusion (I/R) injury. The underlying mechanisms remained largely unclear.
Christoph A Reichel, Max Lerchenberger, Bernd Uhl, Markus Rehberg, Nina Berberich, Stefan Zahler, Matthias P Wymann, Fritz Krombach   +7 more
doaj   +1 more source

Randomized study of aprotinin and DDAVP to reduce postoperative bleeding after cardiopulmonary bypass surgery [PDF]

, 1994
BACKGROUND: Patients on cardiopulmonary bypass (CPB) have an increased susceptibility to postoperative bleeding. Previous reports using desmopressin acetate (DDAVP) for the prevention of postoperative bleeding have given contradictory results, whereas ...
Arroyo, J.L. (José L.), Hidalgo, F. (Francisco), Llorens, R. (Rafael), Melero, J.M. (José María), Paramo, J.A. (José Antonio), Rocha, E. (Eduardo)   +5 more
core   +1 more source

Dextran sulfate activates contact system and mediates arterial hypotension via B2 kinin receptors [PDF]

, 1994
To define some of the mechanisms underlying dextran sulfate (DXS)-induced hypotension, we investigated the effects of either the plasma kallikrein inhibitor des-Pro2-[Arg15] aprotinin (BAY x 4620) or the specific bradykinin B2-receptor antagonist Hoe-140
Cheronis, John C., Fink, Edwin, Fritz, Hans, Jochum, Marianne, Kohl, Jacek, Siebeck, Matthias, Spannagl, Michael, Spies, Bernd   +7 more
core   +4 more sources

Aprotinin and classic wound drainage are unnecessary in total hip replacement a prospective randomized trial

European Journal of Medical Research, 2011
Background Classic wound drainage is still common in hip replacement but its benefit is doubtful. The role of systemic administration of proteinase inhibitors like aprotinin to avoid perioperative blood loss is still unclear.
Fleischmann F, Matuschek C, Orth K, Gerber PA, Mota R, Knoefel WT, Peiper M, Schick M, van Griensven M, Bdlke E, Fleischmann W   +10 more
doaj   +1 more source

Assessment of Early Thromboelastometric Variables from Extrinsically Activated Assays With and Without Aprotinin for Rapid Detection of Fibrinolysis

Anesthesia and Analgesia, 2014
BACKGROUND:Although thromboelastometry (ROTEM®) and thrombelastography can be used for bedside diagnosis of fibrinolysis, the time needed for detection is often prolonged.
D. Dirkmann, Klaus Görlinger, J. Peters
semanticscholar   +1 more source