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Next generation nucleic acid aptamers with two base modified nucleotides improve the binding affinity and potency

2017
Aptamers are single-stranded oligonucleotides (RNA or DNA) that can bind to their targets with high affinities and specificities because of their ability to adopt three-dimensional shapes in solution. Traditionally, aptamers are developed by SELEX (Systematic Evolution of Ligands by Exponential enrichment), a reiterative process involving selection by ...
Naduvile Veedu, Rakesh   +1 more
openaire   +3 more sources

FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle

Cell, 2020
James Lee   +2 more
exaly  

Cyclic Nucleotide Signaling in Phage Defense and Counter-Defense

Annual Review of Virology, 2022
Januka S Athukoralage, Malcolm F White
exaly  

Plant Nucleotide Sugar Formation, Interconversion, and Salvage by Sugar Recycling*

Annual Review of Plant Biology, 2011
Malcolm Oneill, Maor Bar-Peled
exaly  

Understanding nucleotide excision repair and its roles in cancer and ageing

Nature Reviews Molecular Cell Biology, 2014
Jürgen Marteijn   +2 more
exaly  

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