Results 261 to 270 of about 78,567 (340)

The emerging role of aptamers in targeted cancer immunotherapy. [PDF]

Mol Ther Oncol
Zhu S, Xu R, Xu H, Wang Y, Wang L, He N, Wang HH, Ren X.   +7 more
europepmc   +1 more source

AptaGPT: Advancing aptamer design with a generative pre-trained language model

Shi‐Jian Ding, Xin Yang, Chi Ho Chan, Yuan Ma, Sifan Yu, Luyao Wang, Aiping Lyu, Bao‐Ting Zhang, Liang Yu, Ge Zhang   +9 more
openalex   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

Automated high-throughput selection of DNA aptamers using a common optical next-generation sequencer. [PDF]

Nucleic Acids Res
Drees A, Ahlers C, Kehrer T, Ehmke N, Grün AFR, Uetrecht C, Ignatova Z, Schumacher U, Fischer M.   +8 more
europepmc   +1 more source

138P Truncation of HER2 aptamer to enhance its functionalisation capabilities for theranostic treatment of HER2 BC

Chris Vi, Giovanni Mandarano, A.P. Dhillon, Sarah Shigdar   +3 more
openalex   +1 more source

Engineered extracellular vesicles for precision renal therapy: Bioengineering strategies and clinical translation

Interdisciplinary Medicine, EarlyView.
Engineered extracellular vesicles (EVs) offer a versatile platform for kidney‐targeted therapy. This review summarizes bioengineering strategies, including cargo loading, surface modification, biomimetic fabrication, and biomaterial integration. We highlight translational challenges and propose future solutions to accelerate the clinical application of
Linru Shi, Bei Li, Wanzhu Liu, Haifeng Wu, Wenrong Xu, Cheng Ji, Hui Qian   +6 more
wiley   +1 more source

Development of a DNA Aptamer for Screening Neisseria meningitidis Serogroup B by Cell SELEX

, 2017
Kimia Mirzakhani, Seyed Latif Mousavi Gargari, Iraj Rasooli, Samaneh Rasoulinejad   +3 more
openalex   +2 more sources

Tiny carriers, big impact: How Fusobacterium nucleatum extracellular vesicles drive oral diseases and beyond

Interdisciplinary Medicine, EarlyView.
This review explores how Fusobacterium nucleatum extracellular vesicles drive local oral diseases and distal pathologies via sophisticated cross‐compartment cross talk. It highlights the transformative potential of these “tiny carriers” as next‐generation molecular intermediaries for advanced health monitoring and innovative bio‐interventions by ...
Rongyang Ma, Jiahui Huang, Yitong Chen, Haoxuan Wang, Hang Zou, Wanghong Zhao, Zilong Deng   +6 more
wiley   +1 more source

DNA Origami-Templated Aptamer Chiral Structures Realize Cellular Enantioselectivity. [PDF]

Adv Mater
Song T, Dwivedy A, Gandavadi D, Chandran G, An Y, Zheng M, Wang X, Zhou L, Zhao Y, Wang X.   +9 more
europepmc   +1 more source