Results 81 to 90 of about 76,545 (327)
Aptamers as therapeutics [PDF]
Nature Reviews Drug Discovery, 2010 Nucleic acid aptamers can be selected from pools of random-sequence oligonucleotides to bind a wide range of biomedically relevant proteins with affinities and specificities that are comparable to antibodies. Aptamers exhibit significant advantages relative to protein therapeutics in terms of size, synthetic accessibility and modification by medicinal ...
Keefe, Anthony D. +2 more
openaire +2 more sources
Advanced Functional Materials, EarlyView.Nanoscale‐grooved indium gallium oxide (IGO) semiconductors, patterned via thermal nanoimprint lithography (NIL) using CD/DVD templates, are integrated into electrolyte‐gated transistor biosensors to overcome Debye length limitations. Precisely engineered concave–convex nanostructures modulate local electrostatic potentials, extend the effective Debye ...
Jong Yu Song +5 more
wiley +1 more source
Meeting review : ESF workshop on "Impact of nucleic acid chemistry on gene function analysis: antisense, aptamers, ribozymes and RNAi" [PDF]
, 2008 The shortage of functional information compared to the abundance of sequence information characterizes today’s situation in functional genomics. For many years the knock-down of a gene’s product has been the most powerful way of analysing its function ...
Engels, Joachim W. (Prof. Dr.) +3 more
core
Selectivity and specificity: pros and cons in sensing [PDF]
, 2016 Sensing using specific and selective receptors provides two very different but complementary strategies. This Sensor Issues article will discuss the merits and challenges of specific sensors, and selective sensors based on synthetic arrays.
Peveler, William J. +2 more
core +2 more sources
Advanced Healthcare Materials, EarlyView.Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee +9 more
wiley +1 more source
A new lab-on-chip transmitter for the detection of proteins using RNA aptamers [PDF]
, 2010 A new RNA aptamer based affinity biosensor for CReactive Protein (CRP), a risk marker for cardiovascular disease was developed using interdigitated capacitor (IDC), integrated in Voltage Controlled Oscillator (VCO) and output signal is amplified using ...
Gurbuz, Yasar +11 more
core
Principal factors that determine the extension of detection range in molecular beacon aptamer/conjugated polyelectrolyte bioassays. [PDF]
, 2015 A strategy to extend the detection range of weakly-binding targets is reported that takes advantage of fluorescence resonance energy transfer (FRET)-based bioassays based on molecular beacon aptamers (MBAs) and cationic conjugated polyelectrolytes (CPEs).
Bazan, Guillermo C +5 more
core +1 more source
Multivalent Protein Nanorings for Broad and Potent SARS‐CoV‐2 Neutralization
Advanced Healthcare Materials, EarlyView.A protein‐only, modular multivalent nanoscaffold displaying 20 anchor points, decorated with two different binders (10 of each), targeting the SARS‐CoV‐2 receptor‐binding domain is presented. The construct self‐assembles into stable, biocompatible, homogeneous nanoparticles, exhibit synergistic binding with fM IC50 values. It also detects spike at 9 ng
Molood Behbahanipour +11 more
wiley +1 more source
BioTechniques, 2002 Systematic evolution of ligands by exponential enrichment (SELEX) was used to develop DNA ligands (aptamers) to cholera whole toxin and staphylococcal enterotoxin B (SEB).
John G. Bruno, Johnathan L. Kiel
doaj +1 more source
DNA aptamer against EV-A71 VP1 protein: selection and application
Virology Journal, 2021 Background Enterovirus 71 (EV-A71) is a highly infectious pathogen associated with hand, foot and mouth disease, herpangina, and various neurological complications, so it is important for the early detection and treatment of EV-A71.
Xinran Zou +4 more
doaj +1 more source