Results 101 to 110 of about 41,171 (288)
3D structure alignments of aptamers.
, 2023 (a) Alignment of the top three aptamers designed by DAPTEV. (b) Alignment of the median three aptamers designed by DAPTEV. (c) Alignment of the best aptamer designed by DAPTEV with three existing aptamers targeting the RBD of the SARS-CoV-2 spike protein.
Hongbin Yan (416795) +5 more
core +1 more source
Advanced Science, EarlyView.Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang +3 more
wiley +1 more source
G-quadruplex aptamers for cervical cancer therapy [PDF]
, 2020 Annually, more than 500,000 new cervical cancer cases are diagnosed worldwide with a 60% mortality rate. In Portugal, about 750 new cases are annually diagnosed which in 2018 resulted in 340 deaths.
Carvalho, Josué Leandro de Oliveira e
core
Mechanically Triggered DNA Nanovehicles for Targeted Dual‐Drug Cancer Therapy
Advanced Science, EarlyView.A mechanically triggered DNA nanovehicle is introduced that co‐releases two anticancer drugs in response to integrin‐mediated cellular forces. Cholesterol‐anchored DNA assemblies undergo force‐induced unfolding at cell–cell junctions, enabling selective, localized dual‐drug activation in cancer cells while minimizing off‐target toxicity in low‐tension ...
Murali Mohana Rao Singuru +2 more
wiley +1 more source
DNA nanostructure‐programmed intermembrane spacing to modulate T‐cell immunity
Clinical and Translational Medicine, 2023 Yulin Du, Liping Qiu, Weihong Tan
doaj +1 more source
Functional Aptamers in vitro Evolution for Protein-protein Interaction Blockage
As aptamer development progresses, their applications have expanded significantly beyond high affinity to include functional capabilities. Currently, identifying functional aptamers relies on traditional SELEX techniques, followed by functional ...
Qinguo, Liu +3 more
core +1 more source
DNA Nanoarray for Multiplexed RNA Detection With Single‐Molecule Readout
Advanced Science, EarlyView.A carrier‐based DNA nanoarray integrates programmable nucleic acid hybridization with solid‐state nanopore readout for direct RNA detection at single‐molecule resolution. A ternary encoding system enables 27 carriers with 81 addressable sensing sites, allowing the simultaneous identification of targets spanning a wide size range, from short microRNAs ...
Yunxuan Li +12 more
wiley +1 more source
Discovery of Aptamers Targeting Receptor-Binding Domain of the SARS-CoV-2 Spike Glycoprotein
, 2020 The World Health Organization has declared the outbreak of a novel coronavirus (SARS-CoV-2 or 2019-nCoV) as a global pandemic. However, the mechanisms behind the coronavirus infection are not yet fully understood, nor are there any targeted treatments or
Chaoyong, Yang +9 more
core +1 more source
Optimization of SWCNT‐FET Biosensors by Aptamer Engineering and Toehold‐Mediated Strand Displacement
Advanced Science, EarlyView.Aptamer‐based single‐walled carbon nanotube (SWCNT) field‐effect transistor (FET) biosensors are developed for label‐free, real‐time biomarker detection. Truncated DNA aptamers enhance sensitivity through improved conformational switching. A toehold‐mediated strand displacement (TMSD) strategy optimizes functionalization and simplifies fabrication. The
Haosen Miao +8 more
wiley +1 more source