Results 71 to 80 of about 75,608 (261)

Identification and characterization of potent and selective aquaporin-3 and aquaporin-7 inhibitors

Journal of Biological Chemistry, 2019
The aquaglyceroporins are a subfamily of aquaporins that conduct both water and glycerol. Aquaporin-3 (AQP3) has an important physiological function in renal water reabsorption, and AQP3-mediated hydrogen peroxide (H2O2) permeability can enhance cytokine
Y. Sonntag, Patrizia Gena, A. Maggio, T. Singh, I. Artner, M. Oklinski, U. Johanson, P. Kjellbom, J. Nieland, S. Nielsen, G. Calamita, M. Rützler   +11 more
semanticscholar   +1 more source

Resident Macrophage‐Orchestrated Immune and Fibroblast Interactions in Immune Checkpoint Inhibitor‐Associated Nephrotoxicity

Advanced Science, EarlyView.
Schematic illustration of resident macrophages in Immune checkpoint inhibitor‐associated nephrotoxicity (ICI‐AN). Using an integrated approach (including imaging mass cytometry, transcriptomics, and murine models), this study reveals that resident macrophages drive immune‐stromal interactions in ICI‐AN, promoting fibroblast activation through CXCL9 and
Yanhong Ma, Yang Chen, Qinfan Yao, Yuxi Wang, Nan Ouyang, Fei Han, Guzong Wang, Meifang Wang, Yuan Yuan, Jianghua Chen, Jianzhen Shan, Dajin Chen   +11 more
wiley   +1 more source

The AQP2 mutation V71M causesnephrogenic diabetes insipidus in humans but does not impair the function of a bacterial homolog

FEBS Open Bio, 2015
Several point mutations have been identified in human aquaporins, but their effects on the function of the respective aquaporins are mostly enigmatic. We analyzed the impact of the aquaporin 2 mutation V71M, which causesnephrogenic diabetes insipidus in ...
Noreen Klein, Nadine Kümmerer, Dominika Hobernik, Dirk Schneider   +3 more
doaj   +1 more source

Endo-Porter–mediated delivery of phosphorodiamidate morpholino oligos (PMOs) in erythrocyte suspension cultures from Cope's gray treefrog Hyla chrysoscelis

BioTechniques, 2011
Cope's gray treefrog, Hyla chrysoscelis, is a freeze-tolerant anuran that accumulates cryoprotective glycerol during cold acclimation. H. chrysoscelis erythrocytes express the aquaglyceroporin HC-3, which facilitates transmembrane glycerol and water ...
Venkateshwar Mutyam, Matthew V. Puccetti, James Frisbie, David L. Goldstein, Carissa M. Krane   +4 more
doaj   +1 more source

A proteomic and phosphoproteomic analysis of Oryza sativa plasma membrane and vacuolar membrane [PDF]

, 2008
Proteomic and phosphoproteomic analyses of rice shoot and root tonoplast-enriched and plasma membrane-enriched membrane fractions were carried out to look at tissue-specific expression, and to identify putative regulatory sites of membrane transport ...
Ahn, Alexandersson, Armengaud, Banuelos, Benschop, Brugiere, Carter, Chrispeels, Ducos, Dunkley, Endler, Gaxiola, Gierth, Jacquinod, Komatsu, Larsson, Loque, Lüttge, Ma, Maathuis, Maathuis, Marmagne, Morsomme, Niittyla, Nühse, Nühse, Paszkowski, Peltier, Pighin, Rentsch, Sancenon, Tanaka, Tornroth-Horsefield, Toyofuku, Vitart, Whiteman, Wintz, Wu, Yazaki   +38 more
core   +1 more source

Condition-dependent generation of aquaporin-4 antibodies from circulating B cells in neuromyelitis optica

Brain : a journal of neurology, 2018
Aquaporin-4 antibodies are pathogenic in neuromyelitis optica spectrum disorders (NMOSD). Wilson et al. show that circulating memory and naïve B cells from patients can differentiate to produce aquaporin-4 antibodies under conditions chosen to mimic ...
Robert Wilson, M. Makuch, Anne-Kathrin Kienzler, J. Varley, Jennifer Taylor, M. Woodhall, Jacqueline A Palace, M. Leite, P. Waters, S. Irani   +9 more
semanticscholar   +1 more source

RIPK1 Drives JAK1‐STAT3 Signaling to Promote CXCL1‐Mediated Neutrophil Recruitment in Sepsis‐Induced Lung Injury

Advanced Science, EarlyView.
This article examines the central role of RIPK1 in the pathogenesis of sepsis‐induced lung injury. It elucidates how RIPK1 initiates an inflammatory cascade by activating JAK1‐STAT3 signaling, leading to CXCL1‐mediated neutrophil infiltration. Importantly, it demonstrates that pharmacological inhibition of RIPK1 effectively attenuates inflammation and ...
Hao Sun, Xiya Li, Shenjia Gao, Yi Jiang, Xinyi Wu, Zhaoyuan Chen, Han Wu, Qing Hua, Rui Zu, Huaijiang Xiang, Ronen Ben‐Ami, Changhong Miao, Li Tan, Ying Li, Jun Wang, Wankun Chen   +15 more
wiley   +1 more source

Aquaporin-4-dependent K(+) and water transport modeled in brain extracellular space following neuroexcitation. [PDF]

, 2013
Potassium (K(+)) ions released into brain extracellular space (ECS) during neuroexcitation are efficiently taken up by astrocytes. Deletion of astrocyte water channel aquaporin-4 (AQP4) in mice alters neuroexcitation by reducing ECS [K(+)] accumulation ...
Binder, Devin K, Jin, Byung-Ju, Verkman, AS, Zhang, Hua   +3 more
core   +2 more sources

Cerebral Organoids with Integrated Endothelial Networks Emulate the Neurovascular Unit and Mitigate Core Necrosis

Advanced Science, EarlyView.
Fumadó Navarro et al. present an optimized strategy to generate vascular‐like networks that infiltrate within cerebral organoids with promising signs of blood‐brain barrier characteristics, preserved stiffness, uniform morphology, enhanced media diffusion, and reduced necrotic core.
Josep Fumadó Navarro, Siobhan Crilly, Wai Kit Chan, Shane Browne, John O. Mason, Catalina Vallejo‐Giraldo, Abhay Pandit, Mihai Lomora   +7 more
wiley   +1 more source

Ammonia toxicity: from head to toe? [PDF]

, 2016
Ammonia is diffused and transported across all plasma membranes. This entails that hyperammonemia leads to an increase in ammonia in all organs and tissues.
Dasarathy, Srinivasan, Mookerjee, Rajeshwar P., Ott, Peter, Rackayova, Veronika, Rangroo Thrane, Vinita, Rose, Christopher, Vairappan, Balasubramaniyan   +6 more
core   +1 more source