Results 71 to 80 of about 112,802 (343)

Aquaporin-4 autoimmunity [PDF]

Neurology Neuroimmunology & Neuroinflammation, 2015
Neuromyelitis optica (NMO) and a related spectrum of inflammatory CNS disorders are unified by detection of a serum autoantibody specific for the aquaporin-4 (AQP4) water channel, which is abundant in astrocytic foot processes. The classic clinical manifestations of NMO are optic neuritis and longitudinally extensive transverse myelitis.
Zekeridou, Anastasia, Lennon, Vanda A.
openaire   +2 more sources

Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan, John R. Mills, Paulina Vargas, Naveen K. Paramasivan, Connie E. Lesnick, Eati Basal, Surendra Dasari, James P. Fryer, Shannon R. Hinson, Joseph Laporta, Amy Espinal, Dennis Fitzgerald, Carolina Garcia, Anna E. Morenkova, Paola Pergami, Anna Shah, Andrew Knight, Reghann LaFrance Corey, Vanda A. Lennon, Anastasia Zekeridou, Sean J. Pittock, Divyanshu Dubey, Andrew McKeon   +22 more
wiley   +1 more source

Interaction Between the SNARE SYP121 and the Plasma Membrane Aquaporin PIP2;7 Involves Different Protein Domains

Frontiers in Plant Science, 2021
Plasma membrane intrinsic proteins (PIPs) are channels facilitating the passive diffusion of water and small solutes. Arabidopsis PIP2;7 trafficking occurs through physical interaction with SNARE proteins including the syntaxin SYP121, a plasma membrane ...
Timothée Laloux, Irwin Matyjaszczyk, Simon Beaudelot, Charles Hachez, François Chaumont   +4 more
doaj   +1 more source

A proteomic and phosphoproteomic analysis of Oryza sativa plasma membrane and vacuolar membrane [PDF]

, 2008
Proteomic and phosphoproteomic analyses of rice shoot and root tonoplast-enriched and plasma membrane-enriched membrane fractions were carried out to look at tissue-specific expression, and to identify putative regulatory sites of membrane transport ...
Ahn, Alexandersson, Armengaud, Banuelos, Benschop, Brugiere, Carter, Chrispeels, Ducos, Dunkley, Endler, Gaxiola, Gierth, Jacquinod, Komatsu, Larsson, Loque, Lüttge, Ma, Maathuis, Maathuis, Marmagne, Morsomme, Niittyla, Nühse, Nühse, Paszkowski, Peltier, Pighin, Rentsch, Sancenon, Tanaka, Tornroth-Horsefield, Toyofuku, Vitart, Whiteman, Wintz, Wu, Yazaki   +38 more
core   +1 more source

Evaluation of the Efficacy and Safety of Satralizumab in a Pregnant NMOSD Patient With AQP4/MOG‐IgG Dual Seropositive: A Case Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Neuromyelitis Optica Spectrum Disorder (NMOSD) is a chronic autoimmune neuroinflammatory disease, typically characterized by antibodies against aquaporin 4 (AQP4‐IgG) or myelin oligodendrocyte glycoprotein (MOG‐IgG). Simultaneous seropositivity for both antibodies in a single patient is exceedingly rare.
Yeting Luo, Shuhua Xie, Xianghong Liu
wiley   +1 more source

The AQP2 mutation V71M causesnephrogenic diabetes insipidus in humans but does not impair the function of a bacterial homolog

FEBS Open Bio, 2015
Several point mutations have been identified in human aquaporins, but their effects on the function of the respective aquaporins are mostly enigmatic. We analyzed the impact of the aquaporin 2 mutation V71M, which causesnephrogenic diabetes insipidus in ...
Noreen Klein, Nadine Kümmerer, Dominika Hobernik, Dirk Schneider   +3 more
doaj   +1 more source

Aquaporin-4 Functionality and Virchow-Robin Space Water Dynamics: Physiological Model for Neurovascular Coupling and Glymphatic Flow. [PDF]

, 2017
The unique properties of brain capillary endothelium, critical in maintaining the blood-brain barrier (BBB) and restricting water permeability across the BBB, have important consequences on fluid hydrodynamics inside the BBB hereto inadequately ...
Igarashi, Hironaka, Kwee, Ingrid L, Nakada, Tsutomu, Suzuki, Yuji   +3 more
core   +1 more source

Multicentre comparison of a diagnostic assay: aquaporin-4 antibodies in neuromyelitis optica

Journal of Neurology Neurosurgery & Psychiatry, 2016
Objective Antibodies to cell surface central nervous system proteins help to diagnose conditions which often respond to immunotherapies. The assessment of antibody assays needs to reflect their clinical utility.
P. Waters, M. Reindl, A. Saiz, Kathrin Schanda, Friederike Tuller, V. Král, Petra Nytrova, O. Sobek, H. H. Nielsen, T. Barington, S. Lillevang, Z. Illés, K. Rentzsch, A. Berthele, T. Berki, L. Granieri, A. Bertolotto, B. Giometto, L. Zuliani, D. Hamann, E. van Pelt, R. Hintzen, R. Höftberger, C. Costa, M. Comabella, X. Montalban, M. Tintoré, A. Siva, A. Altıntaş, G. Deniz, M. Woodhall, Jacqueline A Palace, F. Paul, H. Hartung, O. Aktas, S. Jarius, B. Wildemann, C. Vedeler, A. Ruiz, M. Leite, P. Trillenberg, M. Probst, S. Saschenbrecker, A. Vincent, R. Marignier   +44 more
semanticscholar   +1 more source

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

Endo-Porter–mediated delivery of phosphorodiamidate morpholino oligos (PMOs) in erythrocyte suspension cultures from Cope's gray treefrog Hyla chrysoscelis

BioTechniques, 2011
Cope's gray treefrog, Hyla chrysoscelis, is a freeze-tolerant anuran that accumulates cryoprotective glycerol during cold acclimation. H. chrysoscelis erythrocytes express the aquaglyceroporin HC-3, which facilitates transmembrane glycerol and water ...
Venkateshwar Mutyam, Matthew V. Puccetti, James Frisbie, David L. Goldstein, Carissa M. Krane   +4 more
doaj   +1 more source