Results 41 to 50 of about 37,019 (222)

Altered expression of aquaporin 1 and aquaporin 5 in the cornea after primary blast exposure

Molecular Vision, 2019
Purpose: Our study aimed to determine whether the altered expression of biomarkers linked to corneal injuries, such as the edema-regulating proteins aquaporin-1 and aquaporin-5 (AQP1 and AQP5), occurred following primary blast exposure. Methods: Adult
José David , Jae Hyek , Jennifer S. , Sandra , Leticia , Peter , Jeffery M. , Randolph D. , Matthew A. , Walt , William E. , Brian J.   +11 more
doaj  

RIPK1 Drives JAK1‐STAT3 Signaling to Promote CXCL1‐Mediated Neutrophil Recruitment in Sepsis‐Induced Lung Injury

Advanced Science, EarlyView.
This article examines the central role of RIPK1 in the pathogenesis of sepsis‐induced lung injury. It elucidates how RIPK1 initiates an inflammatory cascade by activating JAK1‐STAT3 signaling, leading to CXCL1‐mediated neutrophil infiltration. Importantly, it demonstrates that pharmacological inhibition of RIPK1 effectively attenuates inflammation and ...
Hao Sun, Xiya Li, Shenjia Gao, Yi Jiang, Xinyi Wu, Zhaoyuan Chen, Han Wu, Qing Hua, Rui Zu, Huaijiang Xiang, Ronen Ben‐Ami, Changhong Miao, Li Tan, Ying Li, Jun Wang, Wankun Chen   +15 more
wiley   +1 more source

Cerebral Organoids with Integrated Endothelial Networks Emulate the Neurovascular Unit and Mitigate Core Necrosis

Advanced Science, EarlyView.
Fumadó Navarro et al. present an optimized strategy to generate vascular‐like networks that infiltrate within cerebral organoids with promising signs of blood‐brain barrier characteristics, preserved stiffness, uniform morphology, enhanced media diffusion, and reduced necrotic core.
Josep Fumadó Navarro, Siobhan Crilly, Wai Kit Chan, Shane Browne, John O. Mason, Catalina Vallejo‐Giraldo, Abhay Pandit, Mihai Lomora   +7 more
wiley   +1 more source

Overexpression of Aquaporin-1 and Caveolin-1 in the Rat Urinary Bladder Urothelium Following Bladder Outlet Obstruction [PDF]

International Neurourology Journal, 2013
Purpose This study was designed to investigate the effect of detrusor overactivity induced by partial bladder outlet obstruction (BOO) on the expression of aquaporin 1 (AQP1) and caveolin 1 (CAV1) in the rat urinary bladder, and to determine the role of ...
Sun-Ouck Kim, Seung Hee Song, Kwangsung Park, Dongdeuk Kwon   +3 more
doaj   +1 more source

Computational Fluid Dynamic Model Prediction of Enhanced Glymphatic Clearance in Response to Focused Ultrasound‐Mediated Blood‐Brain Barrier Opening

Advanced Science, EarlyView.
Focused ultrasound‐mediated blood‐brain barrier opening (FUS BBBO) for enhanced drug delivery also augments glymphatic clearance. A computational model of an arteriole‐venule pair in the brain offers insight into the underlying biotransport mechanisms responsible for this mass clearance effect.
Ryan A. Gladwell, Delaney G. Fisher, Joshua D. Wythe, Christopher B. Highley, John R. Lukens, Richard J. Price   +5 more
wiley   +1 more source

A Transmembrane Protein WAI‐B2 Confers Multiple Disease Resistance in Wheat by Activating Autoimmunity

Advanced Science, EarlyView.
Wheat production is under threat from multiple diseases. This study clones the wheat autoimmunity gene WAI‐B2 from an EMS‐induced mutant that encodes a distinct transmembrane protein conferring resistance to wheat rusts and powdery mildew ‐ two major diseases affecting wheat crops.
Wenling Li, Yongxing Chen, Lei Dong, Guanghao Guo, Huaizhi Zhang, Tao Shen, Gaojie Wang, Lingli Dong, Ping Lu, Miaomiao Li, Dan Qiu, Keyu Zhu, Beibei Li, Yikun Hou, Xuejia Cui, Baoge Huang, Fugang Yang, Hongkui Fu, Delin Li, Zhan Li, Jinghuang Hu, Yunfeng Qu, Huanhuan Lou, Shisheng Chen, Zaifeng Li, Ling Kang, Wuyun Yang, Chengguo Yuan, Hongjie Li, Yusheng Zhao, Zhiyong Liu, Haiyan Jia, Qiuhong Wu   +32 more
wiley   +1 more source

Nanobiotechnology‐Based Approaches for Targeted Glioma Therapy

Advanced NanoBiomed Research, EarlyView.
Nanoparticle systems cross the blood–brain barrier to deliver drugs precisely to glioma cells. Lipid, polymeric, and magnetic carriers enable controlled release, tumor targeting, and microenvironment modulation. These nanoplatforms enhance chemotherapy, radiotherapy, and immunotherapy, improving therapeutic efficacy while reducing systemic toxicity ...
Jinwei Li, Yibo He, Yang Zhang, Lining Arnold Ju, Yao Wang, Jianxuan Zhou, Yinying Chai, Xuhui Hui, ShiYuan Tong, Si Zhang, Yanli Tan, Yinyan Wang   +11 more
wiley   +1 more source

Deficiency of Carbonic Anhydrase II Results in a Urinary Concentrating Defect

Frontiers in Physiology, 2018
Carbonic anhydrase II (CAII) is expressed along the nephron where it interacts with a number of transport proteins augmenting their activity. Aquaporin-1 (AQP1) interacts with CAII to increase water flux through the water channel. Both CAII and aquaporin-
Devishree Krishnan, Devishree Krishnan, Wanling Pan, Megan R. Beggs, Megan R. Beggs, Francesco Trepiccione, Régine Chambrey, Régine Chambrey, Dominique Eladari, Dominique Eladari, Emmanuelle Cordat, Emmanuelle Cordat, Henrik Dimke, R. Todd Alexander, R. Todd Alexander, R. Todd Alexander   +15 more
doaj   +1 more source

3D‐Printed Microfluidic Bioreactor Incorporating Electrospun Scaffolds for Creating an Enhanced Kidney Epithelial Cell Microenvironment

Journal of Applied Polymer Science, EarlyView.
Overview of cell seeding, attachment and scaffold insertion into bioreactor, with potential analyses listed after conditioning period. ABSTRACT Chronic kidney disease stands as a significant global health challenge, exacerbated by an ongoing scarcity of available organs for transplantation.
Todd P. Burton, Andrew P. Johnston, Alison McDonald, Rhiannon Grant, Anthony Callanan   +4 more
wiley   +1 more source

Decreased Expression of Aquaporins as a Feature of Tubular Damage in Lupus Nephritis

Cells
Background: Tubulointerstitial hypoxia is a key factor for lupus nephritis progression to end-stage renal disease. Numerous aquaporins (AQPs) are expressed by renal tubules and are essential for their proper functioning.
Maxime Melchior, Marie Van Eycken, Charles Nicaise, Thomas Duquesne, Léa Longueville, Amandine Collin, Christine Decaestecker, Isabelle Salmon, Christine Delporte, Muhammad Soyfoo   +9 more
doaj   +1 more source