Results 251 to 260 of about 11,586,786 (268)

Renal expression and functions of aquaporin 1 and aquaporin 4 in cattle

Biotechnic & Histochemistry, 2013
Aquaporin (AQP) 1 and AQP 4 are members of the aquaporin water channel family that play an important role in reabsorption of water from the renal tubular fluid to concentrate urine. Studies of renal AQPs have been performed in human, rodents, sheep, dogs and horses.
Korhan Altunbaş, M S Akosman, O Ozden-Akkaya, A Cevik-Demirkan   +3 more
openaire   +3 more sources

Regulation of aquaporin-4 expression in astrocytes

Molecular Brain Research, 2001
Aquaporin-4 (AQP4), a mercury-insensitive water channel protein, is abundant in the central nervous system and is localized in astrocytes and ependymal cells. AQP4 is speculated to maintain the homeostasis of intracellular and extracellular water in the brain, but little is known about the mechanism of induction of its expression.
Toyohiro Tada, Kiyofumi Asai, Makoto Nakanishi, Kazuo Yamada, Yoshihito Fujita, Mitsuhito Mase, Naoki Yamamoto, Kazuya Sobue, Yutaka Miura, Kazuhiro Yoneda, Taiji Kato, Masataka Fujita   +11 more
openaire   +2 more sources

Myelitis in inflammatory disorders associated with myelin oligodendrocyte glycoprotein antibody and aquaporin‐4 antibody: A comparative study in Chinese Han patients

European Journal of Neurology, 2020
Myelitis is an important clinical component of myelin oligodendrocyte glycoprotein antibody (MOG‐ab)‐associated disease (MOGAD) and aquaporin‐4 antibody (AQP4‐ab)‐positive neuromyelitis optica spectrum disorder (NMOSD).
Jingzi ZhangBao, Wenjuan Huang, Lei Zhou, Liang Wang, Xuechun Chang, Chuanzhen Lu, Chongbo Zhao, Jiahong Lu, C. Quan   +8 more
semanticscholar   +1 more source

Neurological autoimmunity targeting aquaporin-4

Neuroscience, 2010
Neuromyelitis optica (NMO) is the first inflammatory autoimmune demyelinating disease of the CNS for which a specific tissue target molecule has been identified--the astrocytic water channel aquaporin-4 (AQP4). Immunological insights have propelled significant advances in understanding the clinical, radiologic and immunopathologic characteristics of ...
Vanda A. Lennon, Shannon R. Hinson, Andrew McKeon   +2 more
openaire   +3 more sources

Inhibition of Aquaporin 4 by antiepileptic drugs

Bioorganic & Medicinal Chemistry, 2009
The potential of antiepileptic drugs (AEDs) to inhibit the water transport properties of aquaporin 4 (AQP4) was investigated using a combination of in silico and in vitro screening methods. Virtual docking studies on 14 AEDs indicated a range of docking energies that spanned approximately 40 kcal/mol, where the most stabilized energies were consistent ...
Tsutomu Nakada, Vincent J. Huber, Ingrid L. Kwee, Mika Tsujita   +3 more
openaire   +2 more sources

CNS aquaporin-4 autoimmunity in children

Neurology, 2008
In adult patients, autoantibodies targeting the water channel aquaporin-4 (AQP4) are a biomarker for a spectrum of CNS inflammatory demyelinating disorders with predilection for optic nerves and spinal cord (neuromyelitis optica [NMO]). Here we describe the neurologic, serologic, and radiographic findings associated with CNS AQP4 autoimmunity in ...
Brian G. Weinshenker, Claudia F. Lucchinetti, Sean J. Pittock, Timothy Lotze, S. Tenenbaum, Jayne Ness, Vanda A. Lennon, Nancy L. Kuntz, Mary Rensel, Karl N. Krecke, J. P. Fryer, Henry A. Homburger, Jill V. Hunter, Andrew McKeon   +13 more
openaire   +3 more sources

Comparison of the Response to Rituximab between Myelin Oligodendrocyte Glycoprotein and Aquaporin‐4 Antibody Diseases

Annals of Neurology, 2019
To compare response to rituximab (RTX) between adult patients positive for myelin oligodendrocyte glycoprotein (MOG) and aquaporin‐4 (AQP4) antibodies.
Pierre Durozard, A. Rico, Clemence Boutiere, A. Maarouf, R. Lacroix, S. Cointe, S. Fritz, C. Brunet, J. Pelletier, R. Marignier, B. Audoin   +10 more
semanticscholar   +1 more source

Aquaporin-4 astrocytopathy in Baló’s disease

Acta Neuropathologica, 2010
Baló's concentric sclerosis (BCS) is considered to be a rare variant of multiple sclerosis and characterized by alternating rings of demyelinated and preserved myelin layers. The mechanism underlying BCS remains to be elucidated. Recently, occurrence of concentric rings of Baló was described in the brainstem of a patient with neuromyelitis optica (NMO).
Satoshi O. Suzuki, Takeshi Matsuoka, Jun Ichi Kira, Takeshi Tabira, Toru Iwaki, Artemio T. Ordinario   +5 more
openaire   +3 more sources

Higher order structure of aquaporin-4

Neuroscience, 2010
Unlike other mammalian AQPs, multiple tetramers of AQP4 associate in the plasma membrane to form peculiar structures called Orthogonal Arrays of Particles (OAPs), that are observable by freeze-fracture electron microscopy (FFEM). However, FFEM cannot give information about the composition of OAPs of different sizes, and due to its technical complexity ...
NICCHIA, GRAZIA PAOLA, SVELTO, Maria, FRIGERI, Antonio, ROSSI A, MOLA MG, PISANI, FRANCESCO, STIGLIANO C, BASCO D, MASTROTOTARO M   +8 more
openaire   +4 more sources

Identification of arylsulfonamides as Aquaporin 4 inhibitors

Bioorganic & Medicinal Chemistry Letters, 2007
Carbonic anhydrase inhibitors AZA, EZA, and 4-acetamidobenzsulfonamide were found to inhibit human AQP4-M23 mediated water transport by 80%, 68%, and 23%, respectively, at 20 microM in an in vitro functional assay. AZA was found to have an IC50 against AQP4 of 0.9 microM. Phloretin was inactive under the same conditions.
Tsutomu Nakada, Vincent J. Huber, Kenji Sakimura, Mika Tsujita, Maya Yamazaki   +4 more
openaire   +3 more sources