Results 261 to 270 of about 43,591 (296)

The role of aquaporin 4 in the brain

Veterinary Clinical Pathology, 2012
Abstract:Emerging evidence suggests that aquaporin (AQP) 4 water channels play an important role in water homeostasis in the brain. These water channels are most abundant in the cell membrane of astrocytes, but are also present within ependymal cell membranes and in osmosensory areas of the hypothalamus.
Christine, Iacovetta, Elke, Rudloff, Rebecca, Kirby   +2 more
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Hydrocephalus and Aquaporins: The Role of Aquaporin-4

2011
Aquaporins (AQPs) are membrane proteins that facilitate water and small solute movement in tissues. Hydrocephalus is the major central nervous system disorder associated with defective cerebrospinal fluid turnover. Aquaporin-4 (AQP4) is a water channel located mainly at the blood-brain barrier (BBB) and blood-cerebrospinal fluid (CSF) interfaces and is
A S, Filippidis, M Y S, Kalani, H L, Rekate   +2 more
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Aquaporin-4 and Alzheimer’s Disease

Journal of Alzheimer's Disease, 2016
Alzheimer’s disease (AD) is the most common form of dementia. Although the pathogenesis of AD remains unclear, AD is thought to result from an imbalance in the production and clearance of amyloid-β protein (Aβ). Aquaporin-4 (AQP4) is the major aquaporin in the mammalian brain, is mostly expressed on astrocytic endfeet, and functions as a water ...
Canhong, Yang, Xiaomin, Huang, Xiaoyu, Huang, Hantao, Mai, Jie, Li, Tao, Jiang, Xiaofeng, Wang, Tianming, Lü   +7 more
openaire   +2 more sources

Aquaporins in skeletal muscle: reassessment of the functional role of aquaporin‐4

The FASEB Journal, 2004
ABSTRACT Aquaporin‐4 (AQP4) is the major water channel of the neuromuscular system, but its physiological function in both perivascular astrocytes and skeletal muscle sarcolemma is unclear. The purpose of this study was to assess the following in skeletal muscle: a) the expression of all cloned water cannels; b ...
FRIGERI, Antonio, NICCHIA, GRAZIA PAOLA, NICO, Beatrice, SVELTO, Maria, BALENA R   +4 more
openaire   +3 more sources

Aquaporin-4 autoantibodies cause asymptomatic aquaporin-4 loss and activate astrocytes in mouse

Journal of Neuroimmunology, 2012
Neuromyelitis optica (NMO) is a central nervous system inflammatory demyelinating disorder. Up to 90% of patients are seropositive for aquaporin-4 autoantibodies (AQP4 Ab). The pathogenetic mechanisms underlying clinical onset and relapse of NMO are uncertain.Study the pathogenicity of AQP4 Ab in the absence of complement activation.Female C57BL/6N ...
Chan, KH, Chu, ACY, Ho, PWL, Ho, JWM, Zhang, R, Kwan, JSC, Guo, VY   +6 more
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Regulation of aquaporin-4 expression in astrocytes

Molecular Brain Research, 2001
Aquaporin-4 (AQP4), a mercury-insensitive water channel protein, is abundant in the central nervous system and is localized in astrocytes and ependymal cells. AQP4 is speculated to maintain the homeostasis of intracellular and extracellular water in the brain, but little is known about the mechanism of induction of its expression.
K, Yoneda, N, Yamamoto, K, Asai, K, Sobue, Y, Fujita, M, Fujita, M, Mase, K, Yamada, M, Nakanishi, T, Tada, Y, Miura, T, Kato   +11 more
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Higher order structure of aquaporin-4

Neuroscience, 2010
Unlike other mammalian AQPs, multiple tetramers of AQP4 associate in the plasma membrane to form peculiar structures called Orthogonal Arrays of Particles (OAPs), that are observable by freeze-fracture electron microscopy (FFEM). However, FFEM cannot give information about the composition of OAPs of different sizes, and due to its technical complexity ...
NICCHIA, GRAZIA PAOLA, SVELTO, Maria, FRIGERI, Antonio, ROSSI A, MOLA MG, PISANI, FRANCESCO, STIGLIANO C, BASCO D, MASTROTOTARO M   +8 more
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CNS aquaporin-4 autoimmunity in children

Neurology, 2008
In adult patients, autoantibodies targeting the water channel aquaporin-4 (AQP4) are a biomarker for a spectrum of CNS inflammatory demyelinating disorders with predilection for optic nerves and spinal cord (neuromyelitis optica [NMO]). Here we describe the neurologic, serologic, and radiographic findings associated with CNS AQP4 autoimmunity in ...
A, McKeon, V A, Lennon, T, Lotze, S, Tenenbaum, J M, Ness, M, Rensel, N L, Kuntz, J P, Fryer, H, Homburger, J, Hunter, B G, Weinshenker, K, Krecke, C F, Lucchinetti, S J, Pittock   +13 more
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Neurological autoimmunity targeting aquaporin-4

Neuroscience, 2010
Neuromyelitis optica (NMO) is the first inflammatory autoimmune demyelinating disease of the CNS for which a specific tissue target molecule has been identified--the astrocytic water channel aquaporin-4 (AQP4). Immunological insights have propelled significant advances in understanding the clinical, radiologic and immunopathologic characteristics of ...
S R, Hinson, A, McKeon, V A, Lennon
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Aquaporin-4 astrocytopathy in Baló’s disease

Acta Neuropathologica, 2010
Baló's concentric sclerosis (BCS) is considered to be a rare variant of multiple sclerosis and characterized by alternating rings of demyelinated and preserved myelin layers. The mechanism underlying BCS remains to be elucidated. Recently, occurrence of concentric rings of Baló was described in the brainstem of a patient with neuromyelitis optica (NMO).
Takeshi, Matsuoka, Satoshi O, Suzuki, Toru, Iwaki, Takeshi, Tabira, Artemio T, Ordinario, Jun-ichi, Kira   +5 more
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