Results 271 to 280 of about 43,591 (296)

Inhibition of Aquaporin 4 by antiepileptic drugs

Bioorganic & Medicinal Chemistry, 2009
The potential of antiepileptic drugs (AEDs) to inhibit the water transport properties of aquaporin 4 (AQP4) was investigated using a combination of in silico and in vitro screening methods. Virtual docking studies on 14 AEDs indicated a range of docking energies that spanned approximately 40 kcal/mol, where the most stabilized energies were consistent ...
Vincent J, Huber, Mika, Tsujita, Ingrid L, Kwee, Tsutomu, Nakada   +3 more
openaire   +2 more sources

Identification of arylsulfonamides as Aquaporin 4 inhibitors

Bioorganic & Medicinal Chemistry Letters, 2007
Carbonic anhydrase inhibitors AZA, EZA, and 4-acetamidobenzsulfonamide were found to inhibit human AQP4-M23 mediated water transport by 80%, 68%, and 23%, respectively, at 20 microM in an in vitro functional assay. AZA was found to have an IC50 against AQP4 of 0.9 microM. Phloretin was inactive under the same conditions.
Vincent J, Huber, Mika, Tsujita, Maya, Yamazaki, Kenji, Sakimura, Tsutomu, Nakada   +4 more
openaire   +2 more sources

Aquaporin-4, homeostasis, and neurologic disease

Neurology, 2007
Aquaporins constitute a family of water channels that regulate the transport of water in essentially all organs, including the kidney, gastrointestinal tract, secretory glands, inner ear, nervous system, and muscle.1–3 Because of his seminal discovery of aquaporins as the long-sought water channels,1 Peter Agre of Johns Hopkins University was awarded ...
openaire   +2 more sources

[Expression of aquaporin 1 and aquaporin 4 in rat laryngeal tissue].

Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology, 2011
To detect expression level and distribution of aquaporin 1(AQP1) and aquaporin 4 (AQP4) in rat laryngeal tissues and try to find out significance about aquaporin in the laryngeal function and mechanism on the laryngeal diseases.Eight cases laryngeal tissues were obtained from normal wistar rats.
Bing, Guan, Qing feng, Zhang, Zhen, Dong, Zhanquan, Yang   +3 more
openaire   +1 more source

Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema

Cell, 2020
Philip Kitchen, Mootaz M Salman, Justin A Macdonald   +2 more
exaly  

Phosphorylation of a wheat aquaporin at two sites enhances both plant growth and defense

Molecular Plant, 2022
Baoyan Li, Weiyang Wang, Hansong Dong
exaly  

Aquaporin 4 and hydrocephalus

Journal of Neurosurgery: Pediatrics, 2006
James P. McAllister, Janet M. Miller
openaire   +1 more source

Rituximab abrogates aquaporin-4–specific germinal center activity in patients with neuromyelitis optica spectrum disorders

Proceedings of the National Academy of Sciences of the United States of America, 2022
Valentina Damato, Jakob Theorell, Adam Al-Diwani   +2 more
exaly  

Desalination by biomimetic aquaporin membranes: Review of status and prospects

Desalination, 2013
Chuyang Y Tang, Rong Wang, Claus Hélix-Nielsen   +2 more
exaly  

Pathogenic T cell responses against aquaporin 4

Acta Neuropathologica, 2011
Marie-Therese Fischer, Simone Mader, Isabella Wimmer   +2 more
exaly