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mRNA Profiling of Inflammatory Stress Responses after Aquaporin-4 Antibody and Human Complement Treatment Reveals Upregulation of NF-κB and IL6 Pathways

Brandl S, Yu Q, Hagenbuchner J, Endmayr V, Höftberger R, Bradl M, Reindl M.   +6 more
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Aquaporin‐4 and epilepsy

Glia, 2012
AbstractRecent studies have implicated glial cells in modulation of synaptic transmission, so it is plausible that glial cells may have a functional role in the hyperexcitability characteristic of epilepsy. Indeed, alterations in distinct astrocyte membrane channels, receptors, and transporters have all been associated with the epileptic state.
Devin K, Binder, Erlend A, Nagelhus, Ole Petter, Ottersen   +2 more
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Aquaporins, anti-aquaporin-4 autoantibodies and neuromyelitis optica

Clinica Chimica Acta, 2013
The classification, distribution and functions of the different molecules of aquaporins (AQPs), including aquaporins, aquaglyceroporins and superaquaporins are reviewed together with their potential diagnostic and therapeutic uses. We analyzed the pathogenic importance of anti-AQP4 autoantibodies in neuromyelitis optica and related syndromes, as well ...
Concepción, González, José M, González-Buitrago, Guillermo, Izquierdo   +2 more
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Aquaporin-4 and Alzheimer’s Disease

Journal of Alzheimer's Disease, 2016
Alzheimer’s disease (AD) is the most common form of dementia. Although the pathogenesis of AD remains unclear, AD is thought to result from an imbalance in the production and clearance of amyloid-β protein (Aβ). Aquaporin-4 (AQP4) is the major aquaporin in the mammalian brain, is mostly expressed on astrocytic endfeet, and functions as a water ...
Canhong, Yang, Xiaomin, Huang, Xiaoyu, Huang, Hantao, Mai, Jie, Li, Tao, Jiang, Xiaofeng, Wang, Tianming, Lü   +7 more
openaire   +2 more sources

Neurological autoimmunity targeting aquaporin-4

Neuroscience, 2010
Neuromyelitis optica (NMO) is the first inflammatory autoimmune demyelinating disease of the CNS for which a specific tissue target molecule has been identified--the astrocytic water channel aquaporin-4 (AQP4). Immunological insights have propelled significant advances in understanding the clinical, radiologic and immunopathologic characteristics of ...
S R, Hinson, A, McKeon, V A, Lennon
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Hydrocephalus and Aquaporins: The Role of Aquaporin-4

2011
Aquaporins (AQPs) are membrane proteins that facilitate water and small solute movement in tissues. Hydrocephalus is the major central nervous system disorder associated with defective cerebrospinal fluid turnover. Aquaporin-4 (AQP4) is a water channel located mainly at the blood-brain barrier (BBB) and blood-cerebrospinal fluid (CSF) interfaces and is
A S, Filippidis, M Y S, Kalani, H L, Rekate   +2 more
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Aquaporin-4 in hepatic encephalopathy

Metabolic Brain Disease, 2007
Brain edema is a critical component of hepatic encephalopathy (HE) associated with acute liver failure and such edema appears to be principally due to astrocyte swelling (cytotoxic edema). Ammonia is believed to represent a major factor responsible for astrocyte swelling, although the mechanisms by which ammonia causes such swelling are not completely ...
K V, Rama Rao, M D, Norenberg
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Aquaporin-4 autoantibodies cause asymptomatic aquaporin-4 loss and activate astrocytes in mouse

Journal of Neuroimmunology, 2012
Neuromyelitis optica (NMO) is a central nervous system inflammatory demyelinating disorder. Up to 90% of patients are seropositive for aquaporin-4 autoantibodies (AQP4 Ab). The pathogenetic mechanisms underlying clinical onset and relapse of NMO are uncertain.Study the pathogenicity of AQP4 Ab in the absence of complement activation.Female C57BL/6N ...
Chan, KH, Chu, ACY, Ho, PWL, Ho, JWM, Zhang, R, Kwan, JSC, Guo, VY   +6 more
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