Results 271 to 280 of about 69,061 (289)

CNS aquaporin-4 autoimmunity in children

Neurology, 2008
In adult patients, autoantibodies targeting the water channel aquaporin-4 (AQP4) are a biomarker for a spectrum of CNS inflammatory demyelinating disorders with predilection for optic nerves and spinal cord (neuromyelitis optica [NMO]). Here we describe the neurologic, serologic, and radiographic findings associated with CNS AQP4 autoimmunity in ...
A, McKeon, V A, Lennon, T, Lotze, S, Tenenbaum, J M, Ness, M, Rensel, N L, Kuntz, J P, Fryer, H, Homburger, J, Hunter, B G, Weinshenker, K, Krecke, C F, Lucchinetti, S J, Pittock   +13 more
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Higher order structure of aquaporin-4

Neuroscience, 2010
Unlike other mammalian AQPs, multiple tetramers of AQP4 associate in the plasma membrane to form peculiar structures called Orthogonal Arrays of Particles (OAPs), that are observable by freeze-fracture electron microscopy (FFEM). However, FFEM cannot give information about the composition of OAPs of different sizes, and due to its technical complexity ...
NICCHIA, GRAZIA PAOLA, SVELTO, Maria, FRIGERI, Antonio, ROSSI A, MOLA MG, PISANI, FRANCESCO, STIGLIANO C, BASCO D, MASTROTOTARO M   +8 more
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Aquaporin-4 astrocytopathy in Baló’s disease

Acta Neuropathologica, 2010
Baló's concentric sclerosis (BCS) is considered to be a rare variant of multiple sclerosis and characterized by alternating rings of demyelinated and preserved myelin layers. The mechanism underlying BCS remains to be elucidated. Recently, occurrence of concentric rings of Baló was described in the brainstem of a patient with neuromyelitis optica (NMO).
Takeshi, Matsuoka, Satoshi O, Suzuki, Toru, Iwaki, Takeshi, Tabira, Artemio T, Ordinario, Jun-ichi, Kira   +5 more
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Heterotetrameric Composition of Aquaporin-4 Water Channels

Biochemistry, 1999
Aquaporin (AQP) water channel proteins are tetrameric assemblies of individually active approximately 30 kDa subunits. AQP4 is the predominant water channel protein in brain, but immunoblotting of native tissues has previously yielded multiple poorly resolved bands.
Agre, Peter, Nielsen, S, Christensen, B. M., Neely, JD   +3 more
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Aquaporin-4 autoimmune syndrome and anti-aquaporin-4 antibody-negative opticospinal multiple sclerosis in Japanese

Multiple Sclerosis Journal, 2009
Background Antibodies to aquaporin-4 (AQP4) are found in a fraction of Japanese opticospinal multiple sclerosis (OSMS) patients. However, it remains unknown whether anti-AQP4 antibody-positive and negative OSMS patients possess an identical disease.
T, Matsushita, N, Isobe, T, Matsuoka, N, Shi, Y, Kawano, X M, Wu, T, Yoshiura, Y, Nakao, T, Ishizu, J I, Kira   +9 more
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Aquaporin-4, homeostasis, and neurologic disease

Neurology, 2007
Aquaporins constitute a family of water channels that regulate the transport of water in essentially all organs, including the kidney, gastrointestinal tract, secretory glands, inner ear, nervous system, and muscle.1–3 Because of his seminal discovery of aquaporins as the long-sought water channels,1 Peter Agre of Johns Hopkins University was awarded ...
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Regulation of aquaporin-4 expression in astrocytes

Molecular Brain Research, 2001
Aquaporin-4 (AQP4), a mercury-insensitive water channel protein, is abundant in the central nervous system and is localized in astrocytes and ependymal cells. AQP4 is speculated to maintain the homeostasis of intracellular and extracellular water in the brain, but little is known about the mechanism of induction of its expression.
K, Yoneda, N, Yamamoto, K, Asai, K, Sobue, Y, Fujita, M, Fujita, M, Mase, K, Yamada, M, Nakanishi, T, Tada, Y, Miura, T, Kato   +11 more
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Inhibition of Aquaporin 4 by antiepileptic drugs

Bioorganic & Medicinal Chemistry, 2009
The potential of antiepileptic drugs (AEDs) to inhibit the water transport properties of aquaporin 4 (AQP4) was investigated using a combination of in silico and in vitro screening methods. Virtual docking studies on 14 AEDs indicated a range of docking energies that spanned approximately 40 kcal/mol, where the most stabilized energies were consistent ...
Vincent J, Huber, Mika, Tsujita, Ingrid L, Kwee, Tsutomu, Nakada   +3 more
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Clinical spectrum of CNS aquaporin-4 autoimmunity

Neurology, 2012
Traditionally, neuromyelitis optica (NMO) was known to involve only the optic nerves and spinal cord. However, the discovery of highly specific anti-aquaporin-4 (AQP4) antibody for NMO enabled us to identify more diverse clinical manifestations. Here, we describe the demographic and clinical characteristics of patients who were anti-AQP4-antibody ...
S-H, Kim, W, Kim, X F, Li, I-J, Jung, H J, Kim   +4 more
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Aquaporin 4 deficiency modulates morphine pharmacological actions

Neuroscience Letters, 2008
Acute administration of opioids produces analgesia, while chronic administration induces tolerance and dependence. Aquaporin 4 (AQP4) is most strongly expressed in astrocytes throughout central nervous system, and plays an important role in some pathophysiological processes in brain.
Ning, Wu, Xin-Qiang, Lu, Hai-Tao, Yan, Rui-Bin, Su, Ji-Fang, Wang, Yin, Liu, Gang, Hu, Jin, Li   +7 more
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