Results 51 to 60 of about 8,277,314 (334)

KIF15-Mediated Stabilization of AR and AR-V7 Contributes to Enzalutamide Resistance in Prostate Cancer

Cancer Research, 2020
These findings demonstrate how reciprocal activation between KIF15 and AR contributes to enzalutamide resistance in prostate cancer and highlight cotargeting KIF15 and AR as a therapeutic strategy for these tumors.
Lin Gao, Wenbo Zhang, Jing Zhang, Junmei Liu, Feifei Sun, Hui Liu, Jing Hu, Xin Wang, Xueli Wang, P. Su, Shouzhen Chen, Sifeng Qu, B. Shi, Xueting Xiong, Weiwen Chen, Xuesen Dong, B. Han   +16 more
semanticscholar   +1 more source

Androgen receptor phosphorylation at serine 515 by Cdk1 predicts biochemical relapse in prostate cancer patients [PDF]

, 2013
<br>Background:Prostate cancer cell growth is dependent upon androgen receptor (AR) activation, which is regulated by specific kinases. The aim of the current study is to establish if AR phosphorylation by Cdk1 or ERK1/2 is of prognostic ...
BV Kallakury, C E Adams, C Tannahill, D Gioeli, D Gioeli, G Fyffe, GG Kuiper, H Y Leung, H Zong, HY Wong, J Edwards, J Ferlay, J M Willder, JC Obenauer, JS Diallo, K Shigemura, KS McCarty, LA Ponguta, LJ Blok, M A Underwood, M Mistry, M Roach, M Seywright, MS Cookson, NG Anderson, P Chymkowitch, P G Horgan, P McCall, R Mukherjee, RE Bakin, RK Tyagi, S Chen, S Chen, S J Heng, SM Powell, T Kirkegaard, T Ohta, WC Bell, Y Wen, Z Fu, ZX Zhou   +40 more
core   +1 more source

Multivariate Exponentially Weighted Moving Average Control Chart under Neutrosophic Environment: A Bootstrap Approach [PDF]

International Journal of Mathematical, Engineering and Management Sciences
The Multivariate Exponentially Weighted Moving Average (MEWMA) control chart is an effective tool for monitoring small shifts in the mean vector of multiple correlated variables over time.
M. B. Saritha, R. Varadharajan
doaj   +1 more source

Psychological Safety Among Interprofessional Pediatric Oncology Teams in Germany: A Nationwide Survey

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Psychological safety (PS) is essential for teamwork, communication, and patient safety in complex healthcare environments. In pediatric oncology, interprofessional collaboration occurs under high emotional and organizational demands. Low PS may increase stress, burnout, and adverse events.
Alexandros Rahn, Anna‐Lena Herbach, Christian Bock, Katharina Fleig, Urs Mücke   +4 more
wiley   +1 more source

To Be Real, or Not To Be Real, That Is The Question: A Content Analysis of Augmented Reality Articles in Advertising and Marketing Journals from 2017 to 2021

Medya ve Kültür, 2022
This study focuses on 24 published augmented reality (AR) articles in top-tier SSCI indexed advertising and marketing journals with high SJR rankings between 2017 and 2021.
Damla Karşu Cesur
doaj  

The Metaverse: A Brave New "World"

Journal of AI, 2023
As we stand on the precipice of the next significant socio-technological revolution, the Metaverse promises to transform our lives as profoundly as the internet did, if not more.
Artun Cesmeli
doaj   +1 more source

Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands.

Journal of Medicinal Chemistry, 2019
Androgen receptor (AR) is a validated therapeutic target for the treatment of metastatic castration-resistant prostate cancer (mCRPC). We report herein our design, synthesis, and biological characterization of highly potent small-molecule proteolysis ...
Xin-jun Han, Lijie Zhao, Weiguo Xiang, C. Qin, Bukeyan Miao, Tianfeng Xu, Mi Wang, Chao-Yie Yang, Krishnapriya Chinnaswamy, J. Stuckey, Shaomeng Wang   +10 more
semanticscholar   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

MDM2 regulates the stability of AR, AR-V7, and TM4SF3 proteins in prostate cancer

Endocrine Oncology
Androgen receptor (AR) and its constitutively active splice variant, AR Variant 7 (AR-V7), regulate genes essential for the development and progression of prostate cancer. Degradation of AR and AR-V7 by the ubiquitination proteasomal pathway is important
Prabesh Khatiwada, Ujjwal Rimal, Zhengyang Han, Lirim Shemshedini   +3 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source