Results 11 to 20 of about 17,329 (193)
Molecular structure and function of the porcine arachidonate 12-lipoxygenase gene.
Journal of Biological Chemistry, 1992 The gene encoding arachidonate 12-lipoxygenase was cloned from a porcine EMBL3 genomic library using a cDNA probe of the enzyme, and its nucleotide sequence was determined. The gene consists of 14 exons with 13 introns, and spans approximately 8 kilobases.
T, Arakawa +4 more
openaire +3 more sources
12-HETE is an Endogenous Modulator of BLT2 Triggering Vascular Degeneration, Dissection, and Rupture. [PDF]
Adv Sci (Weinh)In thoracic aortic dissection (TAD), elevated levels of the arachidonic acid metabolite 12‐HETE, produced by macrophage‐specific 12/15‐lipoxygenase (12/15‐LOX), bind to the BLT2 receptor on vascular cells. This activates the NOX‐1/ROS/NF‐κB signaling pathway, leading to IL‐6 release.
Li Y +13 more
europepmc +2 more sources
Association of arachidonate 12-lipoxygenase genotype variation and glycemic control with albuminuria in type 2 diabetes. [PDF]
Am J Kidney Dis, 2008 Liu Y +10 more
europepmc +2 more sources
Genetic Variants in COX2 and ALOX Genes and Breast Cancer Risk in White and Black Women
Frontiers in Oncology, 2021 COX and ALOX genes are involved in inflammatory processes and that may be related to breast cancer risk differentially between White and Black women. We evaluated distributions of genetic variants involved in COX2 and ALOX-related pathways and examined ...
Jennifer M. Mongiovi +10 more
doaj +1 more source
ALOXE3 missense variant in a Chihuahua with autosomal recessive ichthyosis. [PDF]
Anim GenetAbstract Ichthyoses are a heterogenous group of inherited disorders that are characterized by excessive scale formation on the skin. We investigated a Chihuahua with severe scaling since age 12 weeks. The scaling was generalized and involved the entire body and legs. The paw pads were mildly hyperkeratotic.
Vinberg C +5 more
europepmc +2 more sources
The role of vitamin C in the gene expression of oxidative stress markers in fibroblasts from burn patients [PDF]
Acta Cirúrgica Brasileira, 2018 Purpose: To assess the action of vitamin C on the expression of 84 oxidative stress related-genes in cultured skin fibroblasts from burn patients. Methods: Skin samples were obtained from ten burn patients.
Jessica Bonucci +5 more
doaj +1 more source
Research, 2023 Hepatic ischemia–reperfusion (IR) injury is a serious clinical problem that complicates liver resection and transplantation. Despite recent advances in understanding of the pathophysiology of hepatic IR injury, effective interventions and therapeutics ...
Cheng Zhong +16 more
doaj +1 more source
Nature Communications, 2023 Aging is a major risk factor for metabolic disorders. Polyunsaturated fatty acid-derived bioactive lipids play critical roles as signaling molecules in metabolic processes. Nonetheless, their effects on age-related liver steatosis remain unknown. Here we
Jinjie Duan +9 more
doaj +1 more source