Results 11 to 20 of about 10,969 (168)

12-HETE is an Endogenous Modulator of BLT2 Triggering Vascular Degeneration, Dissection, and Rupture. [PDF]

Adv Sci (Weinh)
In thoracic aortic dissection (TAD), elevated levels of the arachidonic acid metabolite 12‐HETE, produced by macrophage‐specific 12/15‐lipoxygenase (12/15‐LOX), bind to the BLT2 receptor on vascular cells. This activates the NOX‐1/ROS/NF‐κB signaling pathway, leading to IL‐6 release.
Li Y, Yu J, Chen W, Wang X, Tan X, Cui J, Wang Y, Xu X, Lin R, Wang Z, Jiang W, Zhong Y, Du J, Wang Y.   +13 more
europepmc   +2 more sources

ALOX15‐Derived Oxylipins Attenuate Macrophage Inflammatory Signaling Via a Gαq–PLC–PKC Pathway [PDF]

FASEB J
ALOX15 expression and its downstream oxylipins, including 12‐HETE and 13‐HODE, are induced in intestinal epithelial and lamina propria immune cells during the early and middle phases of experimental colitis. These endogenous lipid mediators suppress lipopolysaccharide‐induced TNF‐α and IL‐6 production in macrophages without affecting cell viability ...
Hilman A, Ishii Y, Wijatniko B, Rini D, Suzuki T.   +4 more
europepmc   +2 more sources

Abnormalities of Sphingolipids Metabolic Pathways in the Pathogenesis of Psoriasis

Metabolites, 2023
Psoriasis is immune-mediated skin disorder affecting thousands of people. Sphingolipids (SLs) are bioactive molecules present in the epidermis, involved in the following cellular processes: proliferation, differentiation, and apoptosis of keratinocytes ...
Beatriz Burger, Roberta Nicolli Sagiorato, Isabella Cavenaghi, Hosana Gomes Rodrigues   +3 more
doaj   +1 more source

Evidence for cytokine regulation of cholesterol metabolism in herpesvirus-infected arterial cells by the lipoxygenase pathway.

Journal of Lipid Research, 1990
Cytokines such as tumor necrosis factor (TNF), interleukin-1 (IL-1), and gamma-interferon (IF) are produced by activated hematopoietic cells. They possess antiviral activity and have other biological activities such as induction of cell proliferation and
OR Etingin, DP Hajjar
doaj   +1 more source

RNAseq analysis of treatment-dependent signaling changes during inflammation in a mouse cutaneous wound healing model

BMC Genomics, 2021
Background Despite proven therapeutic effects in inflammatory conditions, the specific mechanisms of phytochemical therapies are not well understood. The transcriptome effects of Traumeel (Tr14), a multicomponent natural product, and diclofenac, a non ...
Georges St. Laurent, Ian Toma, Bernd Seilheimer, Konstantin Cesnulevicius, Myron Schultz, Michael Tackett, Jianhua Zhou, Maxim Ri, Dmitry Shtokalo, Denis Antonets, Tisha Jepson, Timothy A. McCaffrey   +11 more
doaj   +1 more source

Inhibition of Oxidative Stress and ALOX12 and NF-κB Pathways Contribute to the Protective Effect of Baicalein on Carbon Tetrachloride-Induced Acute Liver Injury

Antioxidants, 2021
This study investigates the protective effect of baicalein on carbon tetrachloride (CCl4)-induced acute liver injury and the underlying molecular mechanisms.
Chongshan Dai, Hui Li, Yang Wang, Shusheng Tang, Tony Velkov, Jianzhong Shen   +5 more
doaj   +1 more source

Modulation of gentamicin-induced acute kidney injury by myo-inositol oxygenase via the ROS/ALOX-12/12-HETE/GPR31 signaling pathway

JCI Insight, 2022
In this investigation, a potentially novel signaling pathway in gentamicin-induced acute kidney injury—worsened by overexpression of proximal tubular enzyme, myo-inositol oxygenase (MIOX)—was elucidated.
Isha Sharma, Yingjun Liao, Xiaoping Zheng, Yashpal S. Kanwar   +3 more
doaj   +1 more source

Alox12/15 Deficiency Exacerbates, While Lipoxin A4 Ameliorates Hepatic Inflammation in Murine Alcoholic Hepatitis

Frontiers in Immunology, 2020
Alcoholism is one of the leading and increasingly prevalent reasons of liver associated morbidity and mortality worldwide. Alcoholic hepatitis (AH) constitutes a severe disease with currently no satisfying treatment options.
Alexander Queck, Annika F. Fink, Evelyn Sirait-Fischer, Sabrina Rüschenbaum, Dominique Thomas, Ryan G. Snodgrass, Gerd Geisslinger, Gerd Geisslinger, Hideo A. Baba, Jonel Trebicka, Jonel Trebicka, Jonel Trebicka, Jonel Trebicka, Stefan Zeuzem, Andreas Weigert, Christian M. Lange, Bernhard Brüne, Bernhard Brüne   +17 more
doaj   +1 more source

Decreased prostaglandin production by cholesterol-rich macrophages.

Journal of Lipid Research, 1989
The regulation of prostaglandin production by macrophages enriched in cholesterol was examined. Mouse peritoneal macrophages were incubated for 18 h with 25 micrograms/ml of human acetyl-LDL (low density lipoprotein) and trace amounts of labeled ...
S N Mathur, E Albright, F J Field
doaj   +1 more source

Effects of Early Intervention With Maternal Fecal Bacteria and Antibiotics on Liver Metabolome and Transcription in Neonatal Pigs

Frontiers in Physiology, 2019
The establishment of a stable bacterial flora in early life is associated with host metabolism. Studies of fecal microbiota transplantation (FMT) and antibiotics on neonatal pig mainly focused on intestinal development and mucosal immunity, but the ...
Jia-Jia Wan, Jia-Jia Wan, Chun-Hui Lin, Chun-Hui Lin, Er-Du Ren, Er-Du Ren, Yong Su, Yong Su, Wei-Yun Zhu, Wei-Yun Zhu   +9 more
doaj   +1 more source