Results 121 to 130 of about 16,216 (223)

ALOX5 contributes to glioma progression by promoting 5-HETE-mediated immunosuppressive M2 polarization and PD-L1 expression of glioma-associated microglia/macrophages

Journal for ImmunoTherapy of Cancer
Background Oxylipin metabolism plays an essential role in glioma progression and immune modulation in the tumor microenvironment. Lipid metabolic reprogramming has been linked to macrophage remodeling, while the understanding of oxylipins and their ...
Tao Chen, Jiayi Zhou, Jiangang Liu, Jianwei Wang, Zhuohao Liu, Jie Mao, Dinglan Wu, Xiaosheng He, Chenci Wang, Zhengwei Wang, Jiani Lin, Tingzheng Pan, Hongchao Xu   +12 more
doaj   +1 more source

A blockade of leukotriene-mediated Alox5 function provides a new strategy for the treatment of JAK2V617F-induced polycythemia vera

Haematologica
Polycythemia vera (PV) is a hematopoietic stem cell disorder characterized by JAK2V617F, a mutation that gives rise to erythrocytosis. Our previous studies have shown that arachidonate 5-lipoxygenase (Alox5) is a critical driver in PV and the inhibition
Yi Shan, Ngoc DeSouza, Noah Littman, Qiang Qiu, Kathy Nguyen, Yehua Yu, Golam Mohi, Shaoguang Li   +7 more
doaj   +1 more source

HIV X4 Variants Increase Arachidonate 5-Lipoxygenase in the Pulmonary Microenvironment and are associated with Pulmonary Arterial Hypertension. [PDF]

Sci Rep, 2020
Almodovar S, Wade BE, Porter KM, Smith JM, Lopez-Astacio RA, Bijli K, Kang BY, Cribbs SK, Guidot DM, Molehin D, McNair BK, Pumarejo-Gomez L, Perez Hernandez J, Salazar EA, Martinez EG, Huang L, Kessing CF, Suarez-Martinez EB, Pruitt K, Hsue PY, Tyor WR, Flores SC, Sutliff RL.   +22 more
europepmc   +1 more source

Uremic toxin indoxyl sulfate induces trained immunity via the AhR-dependent arachidonic acid pathway in end-stage renal disease (ESRD)

eLife
Trained immunity is the long-term functional reprogramming of innate immune cells, which results in altered responses toward a secondary challenge. Despite indoxyl sulfate (IS) being a potent stimulus associated with chronic kidney disease (CKD)-related ...
Hee Young Kim, Yeon Jun Kang, Dong Hyun Kim, Jiyeon Jang, Su Jeong Lee, Gwanghun Kim, Hee Byung Koh, Ye Eun Ko, Hyun Mu Shin, Hajeong Lee, Tae-Hyun Yoo, Won-Woo Lee   +11 more
doaj   +1 more source

Arachidonate 5-lipoxygenase is essential for biosynthesis of specialized pro-resolving mediators and cardiac repair in heart failure.

Am J Physiol Heart Circ Physiol, 2022
Halade GV, Kain V, Hossain S, Parcha V, Limdi NA, Arora P.   +5 more
europepmc   +1 more source

Oxidative Stress, Lipid Peroxidation and Ferroptosis Are Major Pathophysiological Signatures in the Placental Tissue of Women with Late-Onset Preeclampsia

Antioxidants
Preeclampsia, a serious and potentially life-threatening medical complication occurring during pregnancy, is characterized by hypertension and often accompanied by proteinuria and multiorgan dysfunction.
Miguel A. Ortega, Luis M. Garcia-Puente, Oscar Fraile-Martinez, Tatiana Pekarek, Cielo García-Montero, Julia Bujan, Leonel Pekarek, Silvestra Barrena-Blázquez, Raquel Gragera, Inmaculada C. Rodríguez-Rojo, Patrocinio Rodríguez-Benitez, Laura López-González, Raul Díaz-Pedrero, Melchor Álvarez-Mon, Natalio García-Honduvilla, Juan A. De León-Luis, Coral Bravo, Miguel A. Saez   +17 more
doaj   +1 more source

リン脂質過酸化物の生物有機化学的合成 [PDF]

, 2010
Chemoenzymatic synthesis of 1-stearoyl-2-hydropeoxyacyl-sn-glycerophospholipids including phosphatidylcholine (PC-OOH), phosphatidic acid (PA-OOH), phosphatidylethanolamine (PE-OOH), phosphatidylglycerol (PG-OOH) and phosphatidylserine (PS-OOH).
Aoishi, Akihiro, Baba, Naomichi, Daido, Hiroko, Iwasa, Junkichi, Kaneko, Takao, Kishida, Yasuhiro, Matsuo, Mitsuyoshi, Nakajima, Shuhei, Sasakura, Keiji, Shigeta, Yasutami, Shimizu, Sakayu, Tahara, Shoichi, Yoneda, Kenji   +12 more
core  

Improving fatty liver hemorrhagic syndrome in laying hens through gut microbiota and oxylipin metabolism by Bacteroides fragilis: A potential involvement of arachidonic acid

Animal Nutrition
Bacteroides fragilis (B. fragilis), a crucial commensal bacterium within the gut, has shown connections with hepatic lipid metabolism and inflammation regulation. Nonetheless, the role of B. fragilis in the progression of fatty liver hemorrhagic syndrome
Shaobo Zhang, Manhua You, Youming Shen, Xinghua Zhao, Xin He, Juxiang Liu, Ning Ma   +6 more
doaj   +1 more source

Arachidonate 5-Lipoxygenase [PDF]

, 2020
openaire   +1 more source

Magnolin alleviated DSS‐induced colitis by inhibiting ALOX5‐mediated ferroptosis

Kaohsiung Journal of Medical Sciences
Inflammatory bowel disease (IBD) is a chronic and incurable disorder associated with higher cancer risk and currently faces unsatisfactory treatment outcomes.
Ting Yao, Yuan‐Yuan Yao, Jin‐Zhi Wang, Shi‐Man Jiang, Lan‐Juan Li   +4 more
doaj   +1 more source