Results 121 to 130 of about 5,194 (173)
The 6R-oxygenase activity of arachidonate 5-lipoxygenase purified from porcine leukocytes.
, 1988 Natsuo Ueda, Shogo Yamamoto
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Arachidonate 5-lipoxygenase and its new inhibitors
Journal of Allergy and Clinical Immunology, 1984The 5-lipoxygenases of guinea pig peritoneal polymorphonuclear leukocytes and of rat basophilic leukemia cells have been solubilized, purified partially by affinity chromatography, and shown to convert arachidonic acid principally to 5-hydroperoxy-6,8,11,14- eicosatetraenoic acid.
S, Yamamoto +4 more
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Flavonoids: Potent inhibitors of arachidonate 5-lipoxygenase
Biochemical and Biophysical Research Communications, 1983Various flavonoids were found to be relatively selective inhibitors of arachidonate 5-lipoxygenase which initiates the biosynthesis of leukotrienes with the activity of slow reacting substance of anaphylaxis. Cirsiliol (3',4',5-trihydroxy-6,7-dimethoxyflavone) was most potent, and the enzyme partially purified from rat basophilic leukemia cells was ...
T, Yoshimoto +4 more
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5‐Lipoxygenase‐activating protein stimulates the utilization of arachidonic acid by 5‐lipoxygenase
European Journal of Biochemistry, 19935‐Lipoxygenase (5‐LO) and its activating protein (FLAP) are both required for cellular leukotriene (LT) synthesis, with 5‐LO catalyzing both the synthesis of (5S)‐5‐hydroperoxy 6,8,11,14‐eicosatetraenoic acid (5‐HPETE) from arachidonic acid and the subsequent synthesis of LTA4 from 5‐HPETE. We have previously expressed both human 5‐LO and human FLAP to
M, Abramovitz +5 more
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Journal of Lipid Mediators and Cell Signalling, 1995
In this article, it has been attempted to review data primarily on the activation of human 5-lipoxygenase, in vitro and in the cell. First, structural properties and enzyme activities are described. This is followed by the activating factors: Ca2+, membranes, ATP, and lipid hydroperoxide.
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In this article, it has been attempted to review data primarily on the activation of human 5-lipoxygenase, in vitro and in the cell. First, structural properties and enzyme activities are described. This is followed by the activating factors: Ca2+, membranes, ATP, and lipid hydroperoxide.
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A prenylflavone, artonin E, as arachidonate 5-lipoxygenase inhibitor
Biochemical Pharmacology, 1991Several naturally occurring prenylflavones were tested for their inhibitory actions on arachidonate 5-lipoxygenase purified from porcine leukocytes. Of the compounds tested, artonin E (5'-hydroxymorusin) exhibited the most potent inhibition on arachidonate 5-lipoxygenase (IC50 = 0.36 microM).
G R, Reddy +7 more
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Nuclear Import of Arachidonate 5-Lipoxygenase
2001Leukotrienes are lipid messenger molecules that are secreted by leukocytes to orchestrate a rapid and prolonged immune response. The enzyme 5-lipoxygenase catalyzes the rate-limiting first two steps in the synthesis of leukotrienes from arachidonic acid.
T G, Brock, A M, Healy
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Arachidonic acid inhibits 5-lipoxygenase in human T cells
Biochemical and Biophysical Research Communications, 1986The data on whether T cells produce leukotrienes or other 5-lipoxygenase metabolites of arachidonic acid is conflicting. We report that exogenous arachidonic acid added to phytohemagglutin-stimulated human T cells profoundly inhibits leukotriene B4 production, with 90% inhibition caused by 10(-6) M arachidonic acid. The 12- and 15-lipoxygenase pathways
D, Atluru, E A, Lianos, J S, Goodwin
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