Hemodynamic role of arachidonate 12- and 5-lipoxygenases in nephrotoxic serum nephritis
Kidney International, 1993 The role of arachidonate 12- and 5-lipoxygenation eicosanoids in mediating acute changes in renal hemodynamics was assessed in nephrotoxic serum nephritis (NSN) in the rat. Following a single intravenous injection of nephrotoxic serum (NTS), significant decrements in glomerular filtration rate (GFR) and renal blood flow (RBF) occurred at one hour, and ...
Wu, Sheng-Hua +2 more
openaire +2 more sources
ALOXE3 missense variant in a Chihuahua with autosomal recessive ichthyosis
Animal Genetics, Volume 56, Issue 5, October 2025.Abstract Ichthyoses are a heterogenous group of inherited disorders that are characterized by excessive scale formation on the skin. We investigated a Chihuahua with severe scaling since age 12 weeks. The scaling was generalized and involved the entire body and legs. The paw pads were mildly hyperkeratotic.
Carina Vinberg +5 more
wiley +1 more source
Fatty acids in veterinary medicine and research [PDF]
, 2017 Fatty acid regulation is an essential process for all animals. A number of studies have shown that diet affects the levels/availability of fatty acids in the body but increasingly evidence shows that disease states can alter the amounts within the body ...
Mostyn, Alison +2 more
core +2 more sources
PLOS ONE, 2020 AbstractAmong the first steps in inflammation is the conversion of arachidonic acid (AA) stored in the cell membranes into leukotrienes. This occurs mainly in leukocytes and depends on the interaction of two proteins: 5-lipoxygenase (5LO), stored away from the nuclear membranes until use and 5-lipoxygenase activating protein (FLAP), a transmembrane ...
Ramakrishnan B. Kumar +3 more
openaire +5 more sources
Herbal Medicine for Colorectal Cancer Treatment: Molecular Mechanisms and Clinical Applications
Cell Proliferation, Volume 58, Issue 10, October 2025.Colorectal cancer is a prevalent gastrointestinal tumour and the second deadliest cancer worldwide, affecting approximately 10% of all cancers and cancer‐related deaths. Current clinical methods for treating CRC cause gastrointestinal abnormalities and myelosuppression.
Zuqing Su +5 more
wiley +1 more source
Functional characterization of a novel arachidonic acid 12S-lipoxygenase in the halotolerant bacterium Myxococcus fulvus exhibiting complex social living patterns [PDF]
, 2018 Lipoxygenases are lipid peroxidizing enzymes, which frequently occur in higher plants and mammals. These enzymes are also expressed in lower multicellular organisms but here they are not widely distributed.
Blum, Maximilian +4 more
core +1 more source
Serum metabolic signatures of primary biliary cirrhosis and primary sclerosing cholangitis [PDF]
, 2014 BACKGROUND & AIMS: A greater understanding of cholestatic disease is necessary to advance diagnostic tools and therapeutic options for conditions such as primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC).
Bell, Lauren N. +4 more
core +1 more source
Relationship between Arachidonate 5-Lipoxygenase-Activating Protein Gene and Peripheral Arterial Disease in Elderly Patients Undergoing General Surgery: A Retrospective Observational Study [PDF]
, 2023 Sejong Jin +5 more
openalex +1 more source
Mercapturate Pathway in the Tubulocentric Perspective of Diabetic Kidney Disease [PDF]
, 2019 BACKGROUND: The recent growing evidence that the proximal tubule underlies the early pathogenesis of diabetic kidney disease (DKD) is unveiling novel and promising perspectives.
Antunes, A +7 more
core +1 more source
HIV-infection, atherosclerosis and the inflammatory pathway: candidate gene study in a Spanish HIV-infected population. [PDF]
, 2018 BACKGROUND: Higher prevalence of atherosclerosis and higher cardiovascular risk is observed in HIV-infected individuals. The biological mechanisms underlying these processes are unclear.
Arranz, María Jesús +10 more
core +1 more source