Results 1 to 10 of about 3,155 (186)

Arachidonate lipoxygenases 5 is a novel prognostic biomarker and correlates with high tumor immune infiltration in low-grade glioma [PDF]

Frontiers in Genetics, 2023
Objective: To investigate the prognostic value of arachidonate lipoxygenases 5 (ALOX5) expression and methylation, and explore the immune functions of arachidonate lipoxygenases 5 expression in low-grade glioma (LGG).Materials and Methods: Using ...
Rui-han Pan, Xin Zhang, Zu-peng Chen, Ya-jun Liu   +3 more
doaj   +5 more sources

Growth State-Dependent Expression of Arachidonate Lipoxygenases in the Human Endothelial Cell Line EA.hy926 [PDF]

Cells, 2022
Endothelial cells regulate vascular homeostasis through the secretion of various paracrine molecules, including bioactive lipids, but little is known regarding the enzymes responsible for generating these lipids under either physiological or ...
Mohammad G. Sabbir, Jeffrey T. Wigle, Carla G. Taylor, Peter Zahradka   +3 more
doaj   +2 more sources

ALOX5 contributes to glioma progression by promoting 5-HETE-mediated immunosuppressive M2 polarization and PD-L1 expression of glioma-associated microglia/macrophages [PDF]

Journal for ImmunoTherapy of Cancer
Background Oxylipin metabolism plays an essential role in glioma progression and immune modulation in the tumor microenvironment. Lipid metabolic reprogramming has been linked to macrophage remodeling, while the understanding of oxylipins and their ...
Tao Chen, Jiayi Zhou, Jiangang Liu, Jianwei Wang, Zhuohao Liu, Jie Mao, Dinglan Wu, Xiaosheng He, Chenci Wang, Zhengwei Wang, Jiani Lin, Tingzheng Pan, Hongchao Xu   +12 more
doaj   +2 more sources

Arachidonate 15-lipoxygenase enzyme products increase platelet aggregation and thrombin generation. [PDF]

PLoS ONE, 2014
Atherosclerotic cardiovascular diseases are the leading causes of morbidity and mortality worldwide. We have previously shown that arachidonate 15-lipoxygenase B (ALOX15B) is highly expressed in atherosclerotic carotid plaques, and elucidation of ...
Carolina Vijil, Cecilia Hermansson, Anders Jeppsson, Göran Bergström, Lillemor Mattsson Hultén   +4 more
doaj   +1 more source

Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia [PDF]

, 2014
© The Author 2014. Published by Oxford University Press This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution,
Al-Mahdawi, Al-Mahdawi, Block, Campuzano, Campuzano, Capdevila, Capdevila, Castaldo, Chantrel-Groussard, Chen, Cossee, Dewitt, Durr, Durr, Feng, Genki Hayashi, Gino Cortopassi, Harding, John W. Newman, Kang, Koeppen, Li, Liang, Lin, Lu, Mark Pook, Masi, Michael, Miranda, Node, O'Flaherty, Paupe, Piemonte, Piro, Praticò, Qin, Ristow, Rojo, Samuelsson, Sanchez-Mejia, Schulz, Shan, Shi, Shin, Small, Smith, Strokin, Tan, Teismann, Theresa L. Pedersen, Tian, Wardlaw, Wong, Wong, Xi, Yan, Yan Shen, Zhang   +57 more
core   +4 more sources

Intake and metabolism of omega-3 and omega-6 polyunsaturated fatty acids: nutritional implications for cardiometabolic diseases [PDF]

, 2020
Prospective observational studies support the use of long-chain omega-3 polyunsaturated fatty acids (PUFAs) in the primary prevention of atherosclerotic cardiovascular disease; however, randomised controlled trials, have often reported neutral findings ...
Abdelhamid, Abdelhamid, Al-Hilal, Allayee, Armstrong, Aung, Baylin, Bhatt, Bjermo, Bosch, Bowman, Brown, Burdge, Burr, Cannon, Chavez, Cho, Chowdhury, Colazzo, Contreras, Cormier, Das, Dayton, de Toro-Martin, Demetz, Dorris, Draisma, Dumont, Dumont, Dupuis, Dwyer, Farvid, Fezeu, Floegel, Floegel, Forouhi, Frantz, Fretts, Fumagalli, Gabbs, Gammelmark, Gammelmark, Gillingham, Gol, Gromovsky, Guan, Hamley, Harris, Harris, Harris, Heemskerk, Hellstrand, Hilvo, Hooper, Hu, Illig, Imamura, Innes, Jakobsen, Jamieson, Johnson, Juan, Jäger, Jäger, Keaney, Kemp, Kromhout, Kröger, Kröger, Lankinen, Lemaitre, Leren, Li, Ligthart, Liu, Lu, Mahajan, Maki, Manson, Marklund, Marklund, McManus, Micha, Miettinen, Moltó-Puigmartí, Monk, Monteiro, Mozaffarian, Mozaffarian, Mozaffarian, Nelson, Nicholls, O'Neill, Pan, Piepoli, Powell, Ramsden, Ramsden, Ramsden, Ratnayake, Rimm, Risérus, Rizos, Roncaglioni, Rosqvist, Ross, Sarwar, Serhan, Simopoulos, Sioen, Siscovick, Skeaff, Skulas-Ray, Smith, Standl, Stephensen, Stoffel, Sudmant, Sun, Takkunen, Trumbo, Turpeinen, Wang, Wang, Wei, White, Willer, Woodhill, Wu, Wu, Wu, Xue, Yamagishi, Ye, Yokoyama, Yuan, Zhang   +136 more
core   +1 more source

Interactions between the Parasite Philasterides dicentrarchi and the Immune System of the Turbot Scophthalmus maximus. A Transcriptomic Analysis

Biology, 2020
The present study analyses the interactions between Philasterides dicentrarchi (a ciliate parasite that causes high mortalities in cultured flatfish) and the peritoneal cells of the turbot Scophthalmus maximus during an experimental infection.
Alejandra Valle, José Manuel Leiro, Patricia Pereiro, Antonio Figueras, Beatriz Novoa, Ron P. H. Dirks, Jesús Lamas   +6 more
doaj   +1 more source

5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1. [PDF]

, 2018
The reaction of 5 S,15 S-dihydroperoxyeicosatetraenoic acid (5,15-diHpETE) with human 5-lipoxygenase (LOX), human platelet 12-LOX, and human reticulocyte 15-LOX-1 was investigated to determine the reactivity and relative rates of producing lipoxins (LXs).
Freedman, Cody, Green, Abigail R, Holinstat, Michael, Holman, Theodore R, Liu, Benjamin, Tena, Jennyfer, Tourdot, Benjamin E   +6 more
core   +3 more sources

Oxidative modification of human lipoproteins by lipoxygenases of different positional specificities

Journal of Lipid Research, 1994
Cellular lipoxygenases have been implicated in foam cell formation during the early stages of atherogenesis. We studied the interaction of lipoxygenases of different positional specificities with human lipoproteins and found that the arachidonate 15 ...
H Kühn, J Belkner, H Suzuki, S Yamamoto
doaj   +1 more source

Probing the Electrostatic and Steric Requirements for Substrate Binding in Human Platelet-Type 12-Lipoxygenase. [PDF]

, 2019
Human platelet ALOX12 (hALOX12 or h12-LOX) has been implicated in a variety of human diseases. The present study investigates the active site of hALOX12 to more thoroughly understand how it positions the substrate and achieves nearly perfect regio- and ...
Aleem, Ansari Mukhtar, Alvarez, Gabriella, Deschamps, Joshua, Holman, Theodore, Jacobson, Matthew P, Kalyanaraman, Chakrapani, Tena, Jennyfer, Tsai, Wan-Chen   +7 more
core   +2 more sources