Results 11 to 20 of about 3,184 (177)

Ferroptotic neurodegeneration and diet: a narrative review. [PDF]

Alzheimers Dement
Dietary regimes and separate components have been reported to reduce ferroptosis by (1) altering iron metabolism, (2) increasing antioxidant defense, and (3) reducing lipid peroxidation. This ultimately leads to reduced ferroptosis and neurodegeneration.
van der Burg XR, Toen DV, Ayton S, Pijl H, van der Weerd L.   +4 more
europepmc   +2 more sources

5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1. [PDF]

, 2018
The reaction of 5 S,15 S-dihydroperoxyeicosatetraenoic acid (5,15-diHpETE) with human 5-lipoxygenase (LOX), human platelet 12-LOX, and human reticulocyte 15-LOX-1 was investigated to determine the reactivity and relative rates of producing lipoxins (LXs).
Freedman, Cody, Green, Abigail R, Holinstat, Michael, Holman, Theodore R, Liu, Benjamin, Tena, Jennyfer, Tourdot, Benjamin E   +6 more
core   +3 more sources

Oxidative modification of human lipoproteins by lipoxygenases of different positional specificities

Journal of Lipid Research, 1994
Cellular lipoxygenases have been implicated in foam cell formation during the early stages of atherogenesis. We studied the interaction of lipoxygenases of different positional specificities with human lipoproteins and found that the arachidonate 15 ...
H Kühn, J Belkner, H Suzuki, S Yamamoto
doaj   +1 more source

A Novel Function for 15-Lipoxygenases in Cholesterol Homeostasis and CCL17 Production in Human Macrophages

Frontiers in Immunology, 2018
Arachidonate 15-lipoxygenase (ALOX15) and arachidonate 15-lipoxygenase, type B (ALOX15B) catalyze the dioxygenation of polyunsaturated fatty acids and are upregulated in human alternatively activated macrophages (AAMs) induced by Th2 cytokine interleukin-
Ryan G. Snodgrass, Ekaterina Zezina, Dmitry Namgaladze, Sahil Gupta, Carlo Angioni, Gerd Geisslinger, Gerd Geisslinger, Dieter Lütjohann, Bernhard Brüne   +8 more
doaj   +1 more source

Control of the growth of human breast cancer cells in culture by manipulation of arachidonate metabolism

BMC Cancer, 2007
Background Arachidonate metabolites are important regulators of human breast cancer cells. Production of bioactive lipids are frequently initiated by the enzyme phospholipase A2 which releases arachidonic acid (AA) that is rapidly metabolized by ...
Zhang XiaoYan, Sumaida Dena, Hammamieh Rasha, Das Rina, Jett Marti   +4 more
doaj   +1 more source

Probing the Electrostatic and Steric Requirements for Substrate Binding in Human Platelet-Type 12-Lipoxygenase. [PDF]

, 2019
Human platelet ALOX12 (hALOX12 or h12-LOX) has been implicated in a variety of human diseases. The present study investigates the active site of hALOX12 to more thoroughly understand how it positions the substrate and achieves nearly perfect regio- and ...
Aleem, Ansari Mukhtar, Alvarez, Gabriella, Deschamps, Joshua, Holman, Theodore, Jacobson, Matthew P, Kalyanaraman, Chakrapani, Tena, Jennyfer, Tsai, Wan-Chen   +7 more
core   +2 more sources

Expression of mRNA for phospholipase A(2), cyclooxygenases, and lipoxygenases in cultured human umbilical vascular endothelial and smooth muscle cells and in biopsies from umbilical arteries and veins [PDF]

, 1998
Arachidonic acid (AA) is released by phospholipase A(2) (PLA(2)) and then converted into vasoactive and inflammatory eicosanoids by cyclooxygenases (COX) and lipoxygenases (LOX).
Carlsson, Maria, Gidlöf, Anders, Sirsjö, Allan, Söderkvist, Peter, Uhl, Eberhard, Öst, Martin   +5 more
core   +1 more source

Decreased ovarian reserve, dysregulation of mitochondrial biogenesis, and increased lipid peroxidation in female mouse offspring exposed to an obesogenic maternal diet. [PDF]

, 2015
Maternal diet during pregnancy influences the later life reproductive potential of female offspring. We investigate the molecular mechanisms underlying the depletion of ovarian follicular reserve in young adult females following exposure to obesogenic ...
Aiken, Catherine E, Dearden, Laura, Ozanne, Susan E, Penfold, Naomi C, Tarry-Adkins, Jane L   +4 more
core   +2 more sources

A high-throughput mass spectrometric assay for discovery of human lipoxygenase inhibitors and allosteric effectors. [PDF]

, 2015
Lipoxygenases (LOXs) regulate inflammation through the production of a variety of molecules whose specific downstream effects are not entirely understood due to the complexity of the inflammation pathway.
Holman, Theodore R, Jameson, J Brian, Kenyon, Victor   +2 more
core   +1 more source

Eicosanoids in skin inflammation. [PDF]

, 2012
NoEicosanoids play an integral part in homeostatic mechanisms related to skin health and structural integrity. They also mediate inflammatory events developed in response to environmental factors, such as exposure to ultraviolet radiation, and ...
Agarwal, Albanesi, Andersen, Andoh, Andoh, Anna Nicolaou, Baer, Baer, Baron, Bergers, Black, Boeglin, Boguniewicz, Boyce, Brash, Bray, Bryniarski, Burke, Burr, Calder, Calder, Carlson, Carsberg, Chapkin, Chen, Chene, Church, Colombe, Crespy, De Nucci, Dennis, Doepping, Du, Epp, Fincham, Fisher, Fogh, Fogh, Fogh, Ford-Hutchinson, Gledhill, Goetzl, Gonzalez, Grabbe, Grabbe, Grant, Gresham, Grundmann, Gueck, Hansen, Harris, Honda, Honda, Honma, Hruza, Ikai, Ikai, Ikai, Janssen-Timmen, Jisaka, Judson, Judson, Kanda, Keeney, Keeney, Kolgen, Konger, Kragballe, Kragballe, Krieg, Kudo, Kuhn, Ladd, Leong, Levy, Lowes, Lu, Lu, Martin, Masoodi, Massey, Matsushima, Mayer, Mayser, McCusker, McDaniel, Millard, Miller, Miller, Milne, Muller, Nakajima, Narayanan, Nichols, Nicolaou, Nicolaou, Oka, Oyoshi, Parekh, Pentland, Pietrzak, Pilkington, Proksch, Rhodes, Rhodes, Ricketts, Rijken, Ruzicka, Sato, Satoh, Schafer, Schweiger, Scott, Scott, Scott, Serhan, Serhan, Shimura, Singh, Sjursen, Spanbroek, Stark, Straus, Sugimoto, Tai, Takeda, Ueno, Watanabe, Weber, Xi, Yoo, Zheng, Zhou, Ziboh, Ziboh, Ziboh, Ziboh, Ziboh, Zulfakar, Zuo   +139 more
core   +1 more source