Results 21 to 30 of about 3,155 (186)

Therapeutic Applicability of Anti-Inflammatory and Proresolving Polyunsaturated Fatty Acid-Derived Lipid Mediators

The Scientific World Journal, 2010
The enzymatic oxygenation of polyunsaturated fatty acids by lipoxygenases and cyclo-oxygenases is a resourceful mode of formation of specific autacoids that regulate the extent and pace of the inflammatory response. Arachidonate-derived eicosanoids, such
Gerard L. Bannenberg
doaj   +1 more source

Eicosanoids in skin inflammation. [PDF]

, 2012
NoEicosanoids play an integral part in homeostatic mechanisms related to skin health and structural integrity. They also mediate inflammatory events developed in response to environmental factors, such as exposure to ultraviolet radiation, and ...
Agarwal, Albanesi, Andersen, Andoh, Andoh, Anna Nicolaou, Baer, Baer, Baron, Bergers, Black, Boeglin, Boguniewicz, Boyce, Brash, Bray, Bryniarski, Burke, Burr, Calder, Calder, Carlson, Carsberg, Chapkin, Chen, Chene, Church, Colombe, Crespy, De Nucci, Dennis, Doepping, Du, Epp, Fincham, Fisher, Fogh, Fogh, Fogh, Ford-Hutchinson, Gledhill, Goetzl, Gonzalez, Grabbe, Grabbe, Grant, Gresham, Grundmann, Gueck, Hansen, Harris, Honda, Honda, Honma, Hruza, Ikai, Ikai, Ikai, Janssen-Timmen, Jisaka, Judson, Judson, Kanda, Keeney, Keeney, Kolgen, Konger, Kragballe, Kragballe, Krieg, Kudo, Kuhn, Ladd, Leong, Levy, Lowes, Lu, Lu, Martin, Masoodi, Massey, Matsushima, Mayer, Mayser, McCusker, McDaniel, Millard, Miller, Miller, Milne, Muller, Nakajima, Narayanan, Nichols, Nicolaou, Nicolaou, Oka, Oyoshi, Parekh, Pentland, Pietrzak, Pilkington, Proksch, Rhodes, Rhodes, Ricketts, Rijken, Ruzicka, Sato, Satoh, Schafer, Schweiger, Scott, Scott, Scott, Serhan, Serhan, Shimura, Singh, Sjursen, Spanbroek, Stark, Straus, Sugimoto, Tai, Takeda, Ueno, Watanabe, Weber, Xi, Yoo, Zheng, Zhou, Ziboh, Ziboh, Ziboh, Ziboh, Ziboh, Zulfakar, Zuo   +139 more
core   +1 more source

Functional characterization of a novel arachidonic acid 12S-lipoxygenase in the halotolerant bacterium Myxococcus fulvus exhibiting complex social living patterns [PDF]

, 2018
Lipoxygenases are lipid peroxidizing enzymes, which frequently occur in higher plants and mammals. These enzymes are also expressed in lower multicellular organisms but here they are not widely distributed.
Blum, Maximilian, Goloshchapova, Kateryna, Heydeck, Dagmar, Kuhn, Hartmut, Stehling, Sabine   +4 more
core   +1 more source

ALOX5 (arachidonate 5-lipoxygenase) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on ALOX5 (arachidonate 5-lipoxygenase), with data on DNA, on the protein encoded, and where the gene is implicated.
S Banerjee, S Tuncay
openaire   +1 more source

Preferential Generation of 15-HETE-PE Induced by IL-13 Regulates Goblet Cell Differentiation in Human Airway Epithelial Cells [PDF]

, 2017
Type 2–associated goblet cell hyperplasia and mucus hypersecretion are well known features of asthma. 15-Lipoxygenase-1 (15LO1) is induced by the type 2 cytokine IL-13 in human airway epithelial cells (HAECs) in vitro and is increased in fresh asthmatic ...
Aldrovandi, Maceler, Claesson, Hans-Erik, Coleman, John M., Etling, Emily, Kagan, Valerian, Lauder, Sarah, Minami, Yoshinori, O'Donnell, Valerie Bridget, Tyrrell, Victoria, Wenzel, Sally, Zhao, Jingmin   +10 more
core   +2 more sources

Molecular Mechanisms of Nonalcoholic Fatty Liver Disease: Potential Role for 12-Lipoxygenase [PDF]

, 2017
Nonalcoholic fatty liver disease (NAFLD) is a spectrum of pathologies associated with fat accumulation in the liver. NAFLD is the most common cause of liver disease in the United States, affecting up to a third of the general population.
Anderson, Ryan M., Chalasani, Naga, Mirmira, Raghavendra G., Samala, Niharika, Tersey, Sarah A.   +4 more
core   +1 more source

Predicted protein-protein interactions in the moss Physcomitrella patens: a new bioinformatic resource. [PDF]

, 2015
BACKGROUND: Physcomitrella patens, a haploid dominant plant, is fast becoming a useful molecular genetics and bioinformatics tool due to its key phylogenetic position as a bryophyte in the post-genomic era.
Corley, Aaron, Geisler, Matt, Lang, Daniel, Piatkowski, Brian, Schuette, Scott   +4 more
core   +2 more sources

In Vivo Effect of a Synthetic Amniotic Fluid on Fetal Lung and Gastrointestinal Tract: A Pre‐Clinical Rodent Model

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective Amnioinfusions in anhydramnios aim to promote fetal lung development, but currently used fluids (Normal Saline [NS], Lactated Ringer's [LR]) fail to mimic the intrauterine environment and increase reactive oxygen species (ROS). We developed a synthetic amniotic fluid (Amnio‐well, AW) designed to reduce intrauterine ROS.
Braxton Forde, Stephanie Finoti, Marc Oria, Jose L. Peiro   +3 more
wiley   +1 more source

Serum metabolic signatures of primary biliary cirrhosis and primary sclerosing cholangitis [PDF]

, 2014
BACKGROUND & AIMS: A greater understanding of cholestatic disease is necessary to advance diagnostic tools and therapeutic options for conditions such as primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC).
Bell, Lauren N., Chalasani, Naga, Comerford, Megan, Vuppalanchi, Raj, Wulff, Jacob   +4 more
core   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source