The Scientific World Journal, 2010 The enzymatic oxygenation of polyunsaturated fatty acids by lipoxygenases and cyclo-oxygenases is a resourceful mode of formation of specific autacoids that regulate the extent and pace of the inflammatory response. Arachidonate-derived eicosanoids, such
Gerard L. Bannenberg
doaj +1 more source
The Progress of Ferroptosis of Immune Cells in the Tumor Microenvironment and Its Impact on Tumorigenesis and Development. [PDF]
Immun Inflamm DisThe interplay between ferroptosis and the tumor immune microenvironment significantly influences the outcome of cancer immunotherapy. Inducing ferroptosis in tumor cells and immunosuppressive cells, while preventing ferroptosis in effector immune cells, emerges as a promising strategy to enhance the efficacy of immunotherapy. This review highlights the
Zhan F, Hu Y, Jiang X, Fang Z.
europepmc +2 more sources
Preferential Generation of 15-HETE-PE Induced by IL-13 Regulates Goblet Cell Differentiation in Human Airway Epithelial Cells [PDF]
, 2017 Type 2–associated goblet cell hyperplasia and mucus hypersecretion are well known features of asthma. 15-Lipoxygenase-1 (15LO1) is induced by the type 2 cytokine IL-13 in human airway epithelial cells (HAECs) in vitro and is increased in fresh asthmatic ...
Aldrovandi, Maceler +10 more
core +2 more sources
ALOX5 (arachidonate 5-lipoxygenase) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on ALOX5 (arachidonate 5-lipoxygenase), with data on DNA, on the protein encoded, and where the gene is implicated.
S Banerjee, S Tuncay
openaire +1 more source
Functional characterization of a novel arachidonic acid 12S-lipoxygenase in the halotolerant bacterium Myxococcus fulvus exhibiting complex social living patterns [PDF]
, 2018 Lipoxygenases are lipid peroxidizing enzymes, which frequently occur in higher plants and mammals. These enzymes are also expressed in lower multicellular organisms but here they are not widely distributed.
Blum, Maximilian +4 more
core +1 more source
Predicted protein-protein interactions in the moss Physcomitrella patens: a new bioinformatic resource. [PDF]
, 2015 BACKGROUND: Physcomitrella patens, a haploid dominant plant, is fast becoming a useful molecular genetics and bioinformatics tool due to its key phylogenetic position as a bryophyte in the post-genomic era.
Corley, Aaron +4 more
core +2 more sources
Molecular Mechanisms of Nonalcoholic Fatty Liver Disease: Potential Role for 12-Lipoxygenase [PDF]
, 2017 Nonalcoholic fatty liver disease (NAFLD) is a spectrum of pathologies associated with fat accumulation in the liver. NAFLD is the most common cause of liver disease in the United States, affecting up to a third of the general population.
Anderson, Ryan M. +4 more
core +1 more source
Serum metabolic signatures of primary biliary cirrhosis and primary sclerosing cholangitis [PDF]
, 2014 BACKGROUND & AIMS: A greater understanding of cholestatic disease is necessary to advance diagnostic tools and therapeutic options for conditions such as primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC).
Bell, Lauren N. +4 more
core +1 more source
The sunburn response in human skin is characterized by sequential eicosanoid profiles that may mediate its early and late phases. [PDF]
, 2009 yesSunburn is a commonly occurring acute inflammatory process, with dermal vasodilatation and leukocyte infiltration as central features. Ultraviolet (UV) B-induced hydrolysis of membrane phospholipids releases polyunsaturated fatty acids and their ...
Ann K. Haylett +17 more
core +2 more sources
Advanced Science, EarlyView.This study identifies L‐type calcium channel blockers as novel ferroptosis inhibitors. It reveals that PKCβ, activated in calcium dependent manner, phosphorylates and activates ACSL4 and ALOX15, relocating them to lipid droplets to promote lethal lipid peroxidation and ferroptosis.
Guoyuan Hou +8 more
wiley +1 more source