Diabetic Cardiovascular Disease Induced by Oxidative Stress. [PDF]
, 2015 Cardiovascular disease (CVD) is the leading cause of morbidity and mortality among patients with diabetes mellitus (DM). DM can lead to multiple cardiovascular complications, including coronary artery disease (CAD), cardiac hypertrophy, and heart failure
Adam, Matti +9 more
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Interplay between n-3 and n-6 long-chain polyunsaturated fatty acids and the endocannabinoid system in brain protection and repair. [PDF]
, 2017 The brain is enriched in arachidonic acid (ARA) and docosahexaenoic acid (DHA), long-chain polyunsaturated fatty acids (LCPUFA) of the n-6 and n-3 series, respectively. Both are essential for optimal brain development and function.
A Artmann +147 more
core +1 more source
The emerging role of oxylipins in thrombosis and diabetes. [PDF]
, 2014 The prevalence of cardiovascular disease (CVD), the leading cause of death in the US, is predicted to increase due to the shift in age of the general population and increase in CVD risk factors such as obesity and diabetes.
Ahmed, Intekhab +2 more
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Dimerization of human 5-lipoxygenase [PDF]
, 2017 Human 5-lipoxygenase (5-LO) can form dimers as shown here via native gel electrophoresis, gel filtration chromatography and LILBID (laser induced liquid bead ion desorption) mass spectrometry.
Brutschy, Bernhard +8 more
core
Actions and Mechanisms of Polyunsaturated Fatty Acids on Voltage-Gated Ion Channels [PDF]
, 2017 Polyunsaturated fatty acids (PUFAs) act on most ion channels, thereby having significant physiological and pharmacological effects. In this review we summarize data from numerous PUFAs on voltage-gated ion channels containing one or several voltage ...
Fredrik Elinder, Sara I. Liin
core +1 more source
Association between polymorphisms of arachidonate 12-lipoxygenase (ALOX12) and schizophrenia in a Korean population [PDF]
, 2010 Arachidonic acid (AA), an essential polyunsaturated fatty acid, is one of the major components of neural membranes, which show an altered phospholipid composition in schizophrenia.
Hak-Jae Kim +5 more
core +2 more sources
Anti-inflammatory potential of 2-styrylchromones regarding their interference with arachidonic acid metabolic pathways [PDF]
, 2009 Cyclooxygenases (COXs) are the key enzymes in the biosynthesis of prostanoids. COX-1 is a constitutive enzyme while the expression of COX-2 is highly stimulated in the event of inflammatory processes, leading to the production of large amounts of ...
Cavaleiro, José +6 more
core +2 more sources
THE INFLUENCE OF QUERCETIN CONCENTRATION ON ITS INTERMOLECULAR INTERACTION WITH SOYBEAN LIPOXYGENASE-1 [PDF]
, 2008 As research studies on lipoxygenase inhibition indicate quercetin as a one of the most potent inhibitors of this enzyme, this work presents our results concerning the inhibition of soybean lipoxygease-1 by pure quercetin.
Chedea, Veronica S. +3 more
core +2 more sources
Methyl jasmonate and cis jasmone induce apoptosis in Pc-3 and LncaP prostate cancer lines
, 2005 Methyl jasmonate (MJ) and cis jasmone (CJ), lipid-derived plant stress hormones, were studied for their effects against both hormone dependent (LNCaP) and hormone independent (PC3) human prostate cancer cell lines. Both 2 mM MJ or CJ inhibited the growth
Bathina, Madhavi
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Novel n-3 Immunoresolvents: Structures and Actions [PDF]
, 2014 Resolution of inflammation is now held to be an active process where autacoids promote homeostasis. Using functional-metabololipidomics and in vivo systems, herein we report that endogenous n-3 docosapentaenoic (DPA) acid is converted during inflammation-
Colas, Romain A. +2 more
core +1 more source