Results 61 to 70 of about 3,155 (186)

Efferocytosis in Health and Disease

MedComm, Volume 6, Issue 12, December 2025.
Efferocytosis in health and disease. Efferocytosis integrates apoptotic cell recognition, engulfment, digestion, and reprogramming to link cell clearance with tissue repair. Molecular checkpoints balance “eat‐me” signals such as phosphatidylserine against inhibitory “don't‐eat‐me” cues like CD47, while TAM receptors, scavenger receptors, and integrins ...
Chaofu Li, Yukun Yang, Fating Zhou, Qiuyan Jiang, Yingying Jiang, Xuanjie Huang, Yiqiong Zhang, Zhengmeng Ye, Gang Xu, Guoying Kao, Ke Zhou, Fan Yang, Jun Xiao, Wei Wu, Chuanwei Li   +14 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2015/16:Enzymes [PDF]

, 2015
The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org),
Aldrich, R, Alexander, SPH, Attali, B, Back, M, Barnes, NM, Bathgate, R, Beart, PM, Becirovic, E, Benson, HE, Biel, M, Birdsall, NJ, Boison, D, Brauner-Osborne, H, Broeer, S, Bryant, C, Burnstock, G, Burris, T, Cain, D, Calo, G, Chan, SL, Chandy, KG, Chiang, N, Christakos, S, Christopoulos, A, Chun, JJ, Chung, J-J, Clapham, DE, Connor, MA, Coons, L, Cox, HM, Dautzenberg, FM, Davies, JA, Dent, G, Douglas, SD, Dubocovich, ML, Edwards, DP, Fabbro, D, Faccenda, E, Farndale, R, Fong, TM, Forrest, D, Fowler, CJ, Fuller, P, Gainetdinov, RR, Gershengorn, MA, Goldin, A, Goldstein, SAN, Grimm, SL, Grissmer, S, Gundlach, AL, Hagenbuch, B, Hammond, JR, Hancox, JC, Hartig, S, Hauger, RL, Hay, DL, Hebert, T, Hollenberg, AN, Holliday, ND, Hoyer, D, Ijzerman, AP, Inui, KI, Ishii, S, Jacobson, KA, Jan, LY, Jarvis, GE, Jensen, R, Jetten, A, Jockers, R, Kaczmarek, LK, Kanai, Y, Kang, HS, Karnik, S, Kelly, E, Kerr, ID, Korach, KS, Lange, CA, Larhammar, D, Leeb-Lundberg, F, Leurs, R, Lolait, SJ, Macewan, D, Maguire, JJ, Marrion, N, May, JM, Mazella, J, McArdle, CA, McDonnell, DP, Michel, MC, Miller, LJ, Mitolo, V, Monie, T, Monk, PN, Mouillac, B, Murphy, PM, Nahon, J-L, Nerbonne, J, Nichols, CG, Norel, X, Oakley, R, Offermanns, S, Palmer, LG, Panaro, MA, Pawson, AJ, Perez-Reyes, E, Pertwee, RG, Peters, JA, Pike, JW, Pin, JP, Pintor, S, Plant, LD, Poyner, DR, Prossnitz, ER, Pyne, S, Ren, D, Richer, JK, Rondard, P, Ross, RA, Sackin, H, Safi, R, Sanguinetti, MC, Sartorius, CA, Segaloff, DL, Sharman, JL, Sladek, FM, Southan, C, Stewart, G, Stoddart, LA, Striessnig, J, Summers, RJ, Takeda, Y, Tetel, M, Toll, L, Trimmer, JS, Tsai, M-J, Tsai, SY, Tucker, S, Usdin, TB, Vilargada, J-P, Vore, M, Ward, DT, Waxman, SG, Webb, P, Wei, AD, Weigel, N, Willars, GB, Winrow, C, Wong, SS, Wulff, H, Ye, RD, Young, M, Zajac, J-M   +151 more
core   +4 more sources

Resolution of inflammation in pulmonary arterial hypertension, the influence of sex—An IUPHAR immunopharmacology committee review

British Journal of Pharmacology, Volume 182, Issue 23, Page 5706-5733, December 2025.
Pulmonary arterial hypertension (PAH) is a progressive and life‐threatening disease with limited treatment options. Sex differences are apparent in PAH, specifically in the pathophysiology, prognoses and pharmacological responses of patients. Inflammation and its resolution, which often differ between sexes, are dysregulated in chronic inflammatory ...
Chloe Landy, Miles J. De Blasio, Owen L. Woodman, Pasquale Maffia, Hong Yong Peh, Cheng Xue Qin   +5 more
wiley   +1 more source

Actions and Mechanisms of Polyunsaturated Fatty Acids on Voltage-Gated Ion Channels [PDF]

, 2017
Polyunsaturated fatty acids (PUFAs) act on most ion channels, thereby having significant physiological and pharmacological effects. In this review we summarize data from numerous PUFAs on voltage-gated ion channels containing one or several voltage ...
Fredrik Elinder, Sara I. Liin
core   +1 more source

Diabetic Cardiovascular Disease Induced by Oxidative Stress. [PDF]

, 2015
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality among patients with diabetes mellitus (DM). DM can lead to multiple cardiovascular complications, including coronary artery disease (CAD), cardiac hypertrophy, and heart failure
Adam, Matti, Jagger, Ann, Kayama, Yosuke, Raaz, Uwe, Sakamoto, Masaya, Schellinger, Isabel N, Spin, Joshua M, Suzuki, Hirofumi, Toyama, Kensuke, Tsao, Philip S   +9 more
core   +2 more sources

Interplay between n-3 and n-6 long-chain polyunsaturated fatty acids and the endocannabinoid system in brain protection and repair. [PDF]

, 2017
The brain is enriched in arachidonic acid (ARA) and docosahexaenoic acid (DHA), long-chain polyunsaturated fatty acids (LCPUFA) of the n-6 and n-3 series, respectively. Both are essential for optimal brain development and function.
A Artmann, A Berger, A Bilkei-Gorzo, A Chicca, A Nadjar, A Petroni, A Piyanova, A Tanimura, A Thomazeau, A Thomazeau, A Viader, AA Farooqui, AE Bonnet, AF Domenichiello, AJ Vecchio, AL Groeger, AM Fjell, AP Simopoulos, B Batetta, B Lands, B Lu, BM Fonseca, BN Ames, C Arnold, C Canugovi, C Cipollina, CD Breder, CD Buckley, CE Ramsden, CN Serhan, CN Serhan, CN Serhan, CN Serhan, CT Chen, D Bagga, D Ehninger, D Kempuraj, D Leung, D Piomelli, D Rueda, DK Nomura, E Lien, E Mantzioris, E Molina-Holgado, E Ryberg, EA Placzek, EM Novak, ES Onaivi, G Kaur, GA Garden, GF Grabner, H Sprecher, H Yang, H Yang, HG Kuhn, I Galve-Roperh, I Katona, I Matias, J Liu, JC DeMar Jr, JC Demar Jr, JE Tungen, JF Quinn, JL Harrison, JM Parent, JP Pan, JR Savinainen, JT Wood, JW Phillis, JY Xu, K Jin, K Tsuboi, K Yamagata, K Yurko-Mauro, KD Patel, KD Stark, KE Hopperton, KS Broughton, L Belayev, L Petrocellis De, M Alhouayek, M Aursnes, M Gabbs, M Gabrielli, M Kano, M Lafourcade, M Mecha, M Ouellet, M Perluigi, M Zhu, MA Rashid, MB Goncalves, ME Tremblay, MG Cascio, MK Gregory, MR Flock, MV Sofroniew, MV Sofroniew, N Murataeva, N Murataeva, N Stella, NG Bazan, NG Bazan, NG Bazan, NG Bazan, NR Yerram, P Urquhart, PE Castillo, PJ Jones, PK Yip, R Luostarinen, R Micha, R Yang, RJ Kulmacz, S Forsyth, S Watanabe, S Zelasko, SA Moore, SC Dyall, SC Dyall, SC Dyall, SC Dyall, SC Dyall, SC Strike, SE O’Sullivan, Simon C. Dyall, SN Lim, SU Kim, T Aguado, T Bartsch, T Cassano, T Cederholm, T Larrieu, T Takizawa, TVP Bliss, V Chhor, V Darsalia, V Marzo Di, V Marzo Di, V Smedt-Peyrusse De, W Jiang, WL Huang, X Chen, Y Marchalant, Y Takagi, Y Tian, YC Yung, ZZ Xu   +147 more
core   +1 more source

Dimerization of human 5-lipoxygenase [PDF]

, 2017
Human 5-lipoxygenase (5-LO) can form dimers as shown here via native gel electrophoresis, gel filtration chromatography and LILBID (laser induced liquid bead ion desorption) mass spectrometry.
Brutschy, Bernhard, Cernescu, Mihaela, Ermisch, Michael, Hofmann, Bettina, Häfner, Ann-Kathrin, Hörnig, Michael, Metzner, Julia, Schneider, Gisbert, Steinhilber, Dieter   +8 more
core  

The emerging role of oxylipins in thrombosis and diabetes. [PDF]

, 2014
The prevalence of cardiovascular disease (CVD), the leading cause of death in the US, is predicted to increase due to the shift in age of the general population and increase in CVD risk factors such as obesity and diabetes.
Ahmed, Intekhab, Holinstat, Michael, Tourdot, Benjamin E   +2 more
core   +3 more sources

Anti-inflammatory potential of 2-styrylchromones regarding their interference with arachidonic acid metabolic pathways [PDF]

, 2009
Cyclooxygenases (COXs) are the key enzymes in the biosynthesis of prostanoids. COX-1 is a constitutive enzyme while the expression of COX-2 is highly stimulated in the event of inflammatory processes, leading to the production of large amounts of ...
Cavaleiro, José, Fernandes, Eduarda, Gomes, Ana Sara, Lima, José Costa, Pinto, Diana, Santos, Clementina M.M., Silva, Artur   +6 more
core   +2 more sources

Interactions between prostaglandins, leukotrienes and HIV-1: Possible implications for the central nervous system [PDF]

, 2012
In HIV-1-infected individuals, there is often discordance between viremia in peripheral blood and viral load found in the central nervous system (CNS). Although the viral burden is often lower in the CNS compartment than in the plasma, neuroinflammation ...
Jonathan Bertin, Corinne Barat, Sylvie Méthot, Michel J Tremblay   +3 more
core   +2 more sources