Results 1 to 10 of about 5,273,198 (353)
Haematologica, 2012 Background Cold storage of platelets reduces bacterial growth and preserves their hemostatic properties better than current procedures do. However, storage at 0°C induces [14-3-3ζ-glycoprotein Ibα] association, 14-3-3ζ release from phospho-Bad, Bad ...
Dianne E. van der Wal +6 more
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Nutrition & Metabolism, 2011 Background Linoleic acid, with a DRI of 12-17 g/d, is the most highly consumed polyunsaturated fatty acid in the Western diet and is found in virtually all commonly consumed foods.
Whelan Jay, Rett Brian S
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The discovery and early structural studies of arachidonic acid
Journal of Lipid Research, 2016 Arachidonic acid and esterified arachidonate are ubiquitous components of every mammalian cell. This polyunsaturated fatty acid serves very important biochemical roles, including being the direct precursor of bioactive lipid mediators such as ...
Sarah A. Martin +2 more
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Arachidonic acid cytochrome P450 epoxygenase pathway
Journal of Lipid Research, 2009 Cytochrome P450 (CYP) epoxygenases convert arachidonic acid to four epoxyeicosatrienoic acid (EET) regioisomers, 5,6-, 8,9-, 11,12-, and 14,15-EET, that function as autacrine and paracrine mediators.
Arthur A. Spector
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Arachidonic acid metabolism in health and disease
MedComm, 2023 Arachidonic acid (AA), an n‐6 essential fatty acid, is a major component of mammalian cells and can be released by phospholipase A2. Accumulating evidence indicates that AA plays essential biochemical roles, as it is the direct precursor of bioactive ...
Yiran Zhang +5 more
semanticscholar +1 more source
Effects of Arachidonic Acid Metabolites on Cardiovascular Health and Disease
International Journal of Molecular Sciences, 2021 Arachidonic acid (AA) is an essential fatty acid that is released by phospholipids in cell membranes and metabolized by cyclooxygenase (COX), cytochrome P450 (CYP) enzymes, and lipid oxygenase (LOX) pathways to regulate complex cardiovascular function ...
Yan Zhou +3 more
semanticscholar +1 more source
Frontiers in Immunology, 2021 Macrophage polarization is mainly steered by metabolic reprogramming in the tissue microenvironment, thus leading to distinct outcomes of various diseases.
Miao Xu +6 more
semanticscholar +1 more source
Bifidobacterium breve with α-Linolenic Acid and Linoleic Acid Alters Fatty Acid Metabolism in the Maternal Separation Model of Irritable Bowel Syndrome [PDF]
, 2012 peer-reviewedThe aim of this study was to compare the impact of dietary supplementation with a Bifidobacterium breve strain together with linoleic acid & α-linolenic acid, for 7 weeks, on colonic sensitivity and fatty acid metabolism in rats.
Barrett, Eoin +10 more
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Journal of Neuroinflammation, 2020 Arachidonic acid-derived prostaglandins not only contribute to the development of inflammation as intercellular pro-inflammatory mediators, but also promote the excitability of the peripheral somatosensory system, contributing to pain exacerbation ...
Yongwoo Jang, Minseok Kim, S. Hwang
semanticscholar +1 more source
Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets
Signal Transduction and Targeted Therapy, 2021 The arachidonic acid (AA) pathway plays a key role in cardiovascular biology, carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc.
Bei Wang +8 more
semanticscholar +1 more source