Results 151 to 160 of about 194,523 (350)

The anti-inflammatory effects of Yunnan Baiyao are involved in regulation of the phospholipase A2/arachidonic acid metabolites pathways in acute inflammation rat model

, 2017
Xiaobin Ren, Mingzhu Zhang, Lingxiang Chen, Wanli Zhang, Yu Huang, Huazhen Luo, Ling Li, Hongbing He   +7 more
openalex   +2 more sources

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

High dietary arachidonic acid produces excess eicosanoids, and induces hepatic inflammatory responses, oxidative stress and apoptosis in juvenile Acanthopagrus schlegelii

, 2023
Yangguang Bao, Yuedong Shen, Zhaoxun Wu, Shunshun Tao, Bingqian Yang, Tingting Zhu, Wenli Zhao, Yingying Zhang, Xiaoyi Zhao, Lefei Jiao, Ziyi Wang, Qicun Zhou, Min Jin   +12 more
openalex   +1 more source

Potassium Sorbate Triggers Kidney Injury via Dysregulated Intercellular Communication: A Study Combining Network Toxicology, Machine Learning, Molecular Docking, and Single‐Cell RNA Sequencing

iMetaMed, EarlyView.
Amyloid precursor protein (APP)‐mediated endothelial‐immune cell crosstalk is a novel mechanism for potassium sorbate‐induced renal injury. Multi‐omics integration (network toxicology, machine learning, scRNA‐seq) uncovers this interaction via APP‐CD74/PTGER2 axes, linking oxidative stress and inflammation to renal damage. ABSTRACT Acute kidney injury (
Yimao Wu, Yalun Liang, Jintao Liang, Gokhan Zengin, Qian Zhang, Meng‐Yao Li   +5 more
wiley   +1 more source

Early matrine intervention of gut microbiota for type 2 diabetes prevention

iMetaOmics, EarlyView.
How matrine influences gut microbiota imbalance to prevent the progression of diabetes remains unclear. We conduct experiments using mice to simulate the stages of diabetes development and matrine intervention. Combined with amplicon sequencing, we find that the gut microbiota of diabetic mice continuously changes with the progression of the disease ...
Zhexue Sun, Hujie Lyu, Hailang Xu, Xianjin Qin, Wei Li   +4 more
wiley   +1 more source

Host–microbiota interaction drives 5‐hydroxyindole‐3‐acetic acid production to promote linear growth in infant mice

iMetaOmics, EarlyView.
This study discovered that Lactiplantibacillus plantarum Hi188 promoted linear growth in postweaning mice. Transcriptomic analysis, untargeted metabolomics, and in vitro experiments showed that the elevated levels of 5‐hydroxyindole‐3‐acetic acid (5‐HIAA) activated the hepatic aryl hydrocarbon receptor (AhR) and subsequently promoted insulin‐like ...
Yongmei Yang, Jing Yang, Weiyao Zhang, Linghao Zhou, Chenxu Zhu, Xuguang Zhang, Yuejian Mao, Meiling Zhang   +7 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Production of Arachidonic Acid by Mortierella alpina I49-N18

Food Technology and Biotechnology, 2002
Arachidonic acid (AA), an essential fatty acid in human body, fermented by Mortierella alpina I49-N18 was investigated in a shake-flask, and a 50-ton fermentor.
Ji Wang, Yun Shang, Guohong Gong, Jianming Yao, Zengling Yu, Chengling Yuan   +5 more
doaj  

Arachidonic acid induces ERK activation via Src SH2 domain association with the epidermal growth factor receptor [PDF]

, 2006
Larry D. Alexander, Yaxian Ding, Suganthi Alagarsamy, Xiao-Lan Cui, Janice G. Douglas   +4 more
openalex   +1 more source

Effect of leukotriene B₄, prostaglandin E₂ and arachidonic acid on cytosolic‐free calcium in human neutrophils [PDF]

, 1984
P D Lew, Jean‐Michel Dayer, Claes B. Wollheim, Tullio Pozzan   +3 more
openalex   +1 more source