Redox Regulation and Oxidative Stress in Health and Disease: Mechanisms and Therapeutic Targeting
Reactive species serve crucial roles which are tightly regulated in both physiological as well as disease states. At physiological levels, these species are integral to redox signaling, while uncontrolled redox promotes disease pathology. This review examines the dysregulation of these processes.
Mohammad Hossein Azadi +2 more
wiley +1 more source
A combination of ethanol and arachidonic acid promotes steatosis and endoplasmic reticulum stress and impairs mitochondrial respiration in H9c2 cardiomyoblasts. [PDF]
Ai W, New E, Casey CA, Saraswathi V.
europepmc +1 more source
This article systematically elucidates the molecular mechanisms of colorectal precancerous lesions, introduces cutting‐edge research tools like multi‐omics and organoids, and highlights the potential and prospects of natural products such as berberine, resveratrol, and curcumin in preventing and intervening in colorectal carcinogenesis by modulating ...
Shunji Liu +6 more
wiley +1 more source
Jingfang granules inhibiting LPS-induced acute lung injury via regulating linoleic acid and arachidonic acid metabolism pathway. [PDF]
Fu Y +12 more
europepmc +1 more source
Extracts of Hormophysa triquetra showed antifungal activity with marked hyphal deformities in Fusarium oxysporum and Alternaria alternata. Light microscopy and SEM confirmed structural alterations despite unchanged radial growth. Cucumber assays validated reduced disease incidence, linked to fatty‐acid–rich metabolites detected by GC–MS.
Shazia Bibi +4 more
wiley +1 more source
Prevotella copri alleviates diarrhea in weaning piglets through gut microbiota modulation and arachidonic acid-AHR-NRF2 pathway activation. [PDF]
Lan C +6 more
europepmc +1 more source
TEG platelet mapping and impedance aggregometry to predict platelet transfusion during cardiopulmonary bypass in pediatric patients [PDF]
Baltagi, Sirine +6 more
core +1 more source
Objective Bone destruction associated with active rheumatoid arthritis (RA) remains a major therapeutic challenge, with a lack of reliable molecular markers reflecting bone injury. This study aims to identify novel biomarkers linked to bone destruction in active RA through proteomic analysis, providing new strategies for precise monitoring and targeted
Pengfei Xin +15 more
wiley +1 more source
Pre-activation of T cell immunity potentiates ferroptotic cell death through arachidonic acid hybridized nanovesicles. [PDF]
Lyu Q +6 more
europepmc +1 more source
1. A single‐cell analysis was conducted to investigate the transcriptomic changes in cells within focal cortical dysplasia (FCD). 2. Ferroptosis may play a significant role in the pathogenesis of FCD, potentially contributing to cellular damage and epileptogenesis. 3.
Qingyang Zeng +10 more
wiley +1 more source

