Results 181 to 190 of about 2,614,074 (305)

Identification of RPL4 as a biomarker associated with disulfidptosis and arachidonic acid metabolism in breast cancer. [PDF]

Discov Oncol
Yan T, Yu B, Qian F, Fang L, Zhao Y, Ye D.   +5 more
europepmc   +1 more source

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

Huang'e Capsule Alleviates Experimental Autoimmune Prostatitis in Rats Through Regulation of Linoleic Acid and Arachidonic Acid Metabolism by Metabolomics. [PDF]

Biomed Chromatogr
Hu X, Hu X, Liu W, Wu Z, Huang H, Tao Y.
europepmc   +1 more source

The ongoing oleoylethanolamide story: Therapeutic implications in the control of obesity and its comorbidities

British Journal of Pharmacology, EarlyView.
The global burden of obesity continues to rise, demanding effective pharmacological strategies for individuals in whom prevention alone is insufficient. Recent incretin‐based and multi‐agonist therapies have delivered unprecedented weight loss, demonstrating that the simultaneous modulation of multiple metabolic pathways can optimize body weight ...
Marzia Friuli, Alessia Campagna, Barbara Eramo, Christian Sepe, Annarita Zuena, Silvana Gaetani, Adele Romano   +6 more
wiley   +1 more source

An update on schistosomicide and tumoricide in the future: arachidonic acid. [PDF]

Lipids Health Dis
Tallima H, El Ridi R.
europepmc   +1 more source

KYNU in Gastric Cancer Cells Promotes Tumor Progression by Influencing Macrophage Polarization Via PF4

Cancer Science, EarlyView.
KYNU is upregulated in gastric cancer cells and activates the PI3K/Akt pathway, leading to PF4 secretion. PF4 drives nonclassical macrophage polarization with high expression of S100A8 and MMP7, which promotes tumor proliferation, migration, and invasion while suppressing phagocytosis, thereby accelerating gastric cancer progression.
Xilun Cui, Changfeng Li, Yuanda Liu, Chang Liu, Wei Yang   +4 more
wiley   +1 more source

Target FADS1-arachidonic acid-ferroptosis axis: A metabolic bridge linking matrix stiffness to PDAC stemness. [PDF]

Mater Today Bio
Gong T, Yan J, Zhu H, Guan X, Xing H, Wang Z, Wu D, Zhu B, Zhang X, Ma Y.   +9 more
europepmc   +1 more source

EPHX2 Loss Promotes CRC Migration via EET‐Dependent Chemokine Elevation and Mitochondrial Defect

Cancer Science, EarlyView.
Loss of EPHX2 promotes EET accumulation, which in turn enhances CXCL and ROS production, thereby promoting the migratory and invasive abilities of CRC cells. ABSTRACT Epoxide hydrolase 2 (EPHX2) is a key enzyme in fatty acid metabolism that metabolizes epoxyeicosatrienoic acids (EETs), lipid mediators involved in inflammation, angiogenesis, and ...
Jianjun Zhu, Jingjia Chang, Zhiyong Li, Jin Wu, Pengfei Yu, Jingjing Zheng, Li Li, Jia Tao, Hao Wu, Yintao Li, Ming Liu   +10 more
wiley   +1 more source

SCD1 Regulates Osteoclast Differentiation by Modulating Arachidonic Acid Metabolism and Mitochondrial Homeostasis. [PDF]

FASEB J
Zhao Y, Wei X, Wu H, Yao C, Zheng Z, Chen W, Feng Z, Huang B, Cai Z, Xue Q, Chen J, Zhao F, Liu J.   +12 more
europepmc   +1 more source

Role of Cysteinyl Leukotrienes in Food Allergy and Anaphylaxis: A Potential Therapeutic Target

Allergy, EarlyView.
Adrienn Weingärtner, Thomas Eiwegger
wiley   +1 more source