Results 261 to 270 of about 104,843 (319)

Multi-Omics Reveals the Role of Arachidonic Acid Metabolism in the Gut-Follicle Axis for the Antral Follicular Development of Holstein Cows. [PDF]

Int J Mol Sci
Guo Y, Wang S, Wu X, Zhao R, Chang S, Ma C, Song S, Zeng S.   +7 more
europepmc   +1 more source

Gut Microbiota Dysbiosis: Pathogenesis, Diseases, Prevention, and Therapy

MedComm, Volume 6, Issue 5, May 2025.
ABSTRACT Dysbiosis refers to the disruption of the gut microbiota balance and is the pathological basis of various diseases. The main pathogenic mechanisms include impaired intestinal mucosal barrier function, inflammation activation, immune dysregulation, and metabolic abnormalities.
Yao Shen, Nairui Fan, Shu‐xia Ma, Xin Cheng, Xuesong Yang, Guang Wang   +5 more
wiley   +1 more source

High-throughput optimization of organic carbon provision strategies enables enhanced arachidonic acid production in novel microalgae. [PDF]

Microb Cell Fact
Sim EJ, Lee YR, Park SB, Kim G, Shin BS, Yun JH, Choi HI, Choi DY, Cho DH, Kim HS, Lee YJ.   +10 more
europepmc   +1 more source

Dysregulation of Astrocytic ATP/Adenosine Release in the Hippocampus Cause Cognitive and Affective Disorders: Molecular Mechanisms, Diagnosis, and Therapy

MedComm, Volume 6, Issue 5, May 2025.
Reactive astrocytes release various molecules, which play a role in maintaining central nervous system (CNS) homeostasis. (1) Gliotransmitters, such as glutamate, γ‐aminobutyric acid (GABA), ATP, and D‐serine, are secreted by vesicular exocytosis. In addition, astrocytes can also release ATP and glutamate through (2) P2X7Rs, (3) connexin‐43 (Cx43 ...
Peter Illes, Patrizia Rubini, Henning Ulrich, Hai‐Yan Yin, Yong Tang   +4 more
wiley   +1 more source

The future of pharmacology and therapeutics of the arachidonic acid cascade in the next decade: Innovative advancements in drug repurposing. [PDF]

Front Pharmacol
Patrignani P, Contursi A, Tacconelli S, Steinhilber D.   +3 more
europepmc   +1 more source

Improving Bovine Embryo Development and Quality Using Bovine Oviductal Epithelial Cell‐Derived Conditioned Medium (bOEC‐CM)

Veterinary Medicine and Science, Volume 11, Issue 3, May 2025.
The study investigated the effects of bOEC‐CM on bovine in vitro embryo development. CM from Day 3 enhances blastocyst rate and positively affects the ICM and TE in blastocysts and increases the expression of development‐specific genes. bOEC‐CM may serve as a superior supplement during the final five embryo culture days.
Saeed Kazemi Hosseinabadi, Hassan Nazari, Mehran Arabi, Naser Shams Esfandabadi, Ebrahim Ahmadi, Azita Afzali, Hamidreza Ghanaei   +6 more
wiley   +1 more source

Temporal dissociation of COX-2-dependent arachidonic acid and 2-arachidonoylglycerol metabolism in RAW264.7 macrophages. [PDF]

J Lipid Res
Aleem AM, Mitchener MM, Kingsley PJ, Rouzer CA, Marnett LJ.   +4 more
europepmc   +1 more source

Recycling Agricultural Waste: Sustainable Solutions for Enhancing Livestock Nutrition

Veterinary Medicine and Science, Volume 11, Issue 3, May 2025.
The increasing demand for sustainable agricultural practices prompts a reevaluation of feeding strategies in ruminant nutrition. Agricultural waste, often viewed as a by‐product, presents a promising opportunity to enhance the sustainability of livestock production systems.
Mohsen Kazemi
wiley   +1 more source

Arachidonic acid impairs natural killer cell functions by disrupting signaling pathways driven by activating receptors and reactive oxygen species. [PDF]

Cell Commun Signal
Hammoud MK, Meena C, Dietze R, Hoffmann N, Szymanski W, Finkernagel F, Nist A, Stiewe T, Graumann J, von Strandmann EP, Müller R.   +10 more
europepmc   +1 more source

Role of Inflammatory and Proresolving Mediators in Endothelial Dysfunction

Basic &Clinical Pharmacology &Toxicology, Volume 136, Issue 5, May 2025.
ABSTRACT Excessive local inflammation is a common mechanism in many cardiovascular diseases (CVDs) such as hypertension, atherosclerosis and aortic aneurysms. In endothelial cells, inflammatory cytokines such as interferons, tumour necrosis factor alpha or interleukins increase oxidative stress and contractile prostanoids and the expression of adhesion
Ana M. Briones, Raquel Hernanz, Ana B. García‐Redondo, Cristina Rodríguez, Luis M. Blanco‐Colio, Almudena Val‐Blasco, María J. Alonso, Mercedes Salaices   +7 more
wiley   +1 more source