ABSTRACT Gastrointestinal diseases remain a significant global health concern, primarily due to the limitations of current pharmacological treatments, which often come with adverse side effects and high recurrence rates. This situation highlights the urgent need for safer and more effective alternatives.
Isabel Sousa Alcântara +7 more
wiley +1 more source
CYP1A1/20-HETE/GPR75 Axis-Mediated Arachidonic Acid Metabolism Dysregulation in H-Type Hypertension Pathogenesis. [PDF]
Lv H, Liu L, Bai B, Zhang K, Zhang Q.
europepmc +1 more source
Modulators of Diacylglycerol Kinase Activity: A Review of Advances and Challenges
ABSTRACT Catalyzing the conversion of diacylglycerol (DAG) in phosphatidic acid (PA), diacylglycerol kinases (DGKs) play a pivotal role in all the physiological processes modulated by these two bioactive lipids, such as lipid metabolism and immune regulation.
Luisa Racca +2 more
wiley +1 more source
Role of arachidonic acid metabolism in osteosarcoma prognosis by integrating WGCNA and bioinformatics analysis. [PDF]
Wang Y, Hsu P, Hu H, Lin F, Wei X.
europepmc +1 more source
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li +7 more
wiley +1 more source
Identifying potential biomarkers and molecular mechanisms related to arachidonic acid metabolism in vitiligo. [PDF]
Li X, Yang L, Zhu L, Sun J, Xu C, Sun L.
europepmc +1 more source
Dendritic Cell Migration: An Essential Step in Initiating Adaptive Immunity Across Tissues
ABSTRACT Immune surveillance of tissues is primarily carried out by dendritic cells (DCs), which act as sentinels for the adaptive immune system. To accomplish this task, DCs migrate from tissues to regional lymph nodes, or from blood‐exposed regions of the spleen to the white pulp, to prime T cell responses. DC migration is a tightly regulated process
Eli C. Olson +2 more
wiley +1 more source
Identification and verification of biomarkers associated with arachidonic acid metabolism in non-alcoholic fatty liver disease. [PDF]
Li J +5 more
europepmc +1 more source
TEG platelet mapping and impedance aggregometry to predict platelet transfusion during cardiopulmonary bypass in pediatric patients [PDF]
Baltagi, Sirine +6 more
core +1 more source
Mechanosensing in Dendritic Cells
ABSTRACT Since their discovery, dendritic cells have been recognized for their unusual capacity to sense and respond to physical stimuli within their environment. However, it took nearly two decades—and the advent of mechanobiology—to elucidate the underlying mechanisms and functional implications of this mechanical hypersensitivity. In this review, we
Vincent Calmettes +5 more
wiley +1 more source

