Results 21 to 30 of about 177,677 (360)

Molecular and cellular paradigms of multidrug resistance in cancer

Cancer Reports, Volume 5, Issue 12, December 2022., 2022
Abstract Background The acquisition of resistance to chemotherapy is a major hurdle in the successful application of cancer therapy. Several anticancer approaches, including chemotherapies, radiotherapy, surgery and targeted therapies are being employed for the treatment of cancer.
Foram U. Vaidya, Abu Sufiyan Chhipa, Vinita Mishra, Vishal Kumar Gupta, Shiv Govind Rawat, Ajay Kumar, Chandramani Pathak   +6 more
wiley   +1 more source

Modulation of guanosine triphosphatase activity of G proteins by arachidonic acid in rat Leydig cell membranes [PDF]

, 2000
Previous results from our group have indicated that arachidonic acid decrease cAMP production through a modification of heterotrimericGproteins.\ud In the present study, we have characterized the high affinity GTPase activity present in Leydig cell ...
Colás Escudero, Begoña, López Ruiz, María del Pilar, Marinero Ramos, María Jesús, Prieto Villapún, Juan Carlos, Ropero Salinas, Santiago   +4 more
core   +3 more sources

Arachidonic Acid and the Brain [PDF]

The Journal of Nutrition, 2008
Kinetic methods in unanesthetized rodents have shown that turnover rates of arachidonic acid (AA) and docosahexaenoic acid (DHA) in brain membrane phospholipids are rapid and energy consuming and that phospholipase A(2) (PLA(2)) and acyl-CoA synthetase enzymes that regulate turnover are specific for one or the other PUFA.
openaire   +3 more sources

Arachidonic acid in cell signaling [PDF]

Current Opinion in Cell Biology, 1993
Important advances have recently been made in our understanding of the arachidonic acid cascade. The molecular characterization of different forms of phospholipase A2 indicates that multiple pathways are involved in the release of arachidonic acid evoked by physiological or pathological stimuli.
openaire   +4 more sources

Arachidonic Acid Release and Catecholamine Secretion from Digitonin-Treated Chromaffin Cells: Effects of Micromolar Calcium, Phorbol Ester, and Protein Alkylating Agents [PDF]

, 1985
The relationship between catecholamine secretion and arachidonic acid release from digitonin-treated chromaffin cells was investigated. Digitonin renders permeable the plasma membranes of bovine adrenal chromaffin cells to Ca 2+ , ATP, and proteins ...
Frye, Roy A., Holz, Ronald W.
core   +1 more source

Functional consequences of brain exposure to saturated fatty acids: From energy metabolism and insulin resistance to neuronal damage

Endocrinology, Diabetes &Metabolism, Volume 6, Issue 1, January 2023., 2023
Saturated fatty acids induce insulin resistance in neurons. Neuronal metabolism of palmitic acid alters mitochondrial function. Abstract Introduction Saturated fatty acids (FAs) are the main component of high‐fat diets (HFDs), and high consumption has been associated with the development of insulin resistance, endoplasmic reticulum stress and ...
Karina Sánchez‐Alegría, Clorinda Arias   +1 more
wiley   +1 more source

Arachidonic acid-induced release of calcium in permeabilized human neutrophils [PDF]

, 1987
The addition of arachidonic acid to a suspension of digitonin-permeabilized human neutrophils was found to induce, in a dose-dependent manner (ED50 about 15 μM), the release of calcium from internal stores.
Beaumier, L., Faucher, N., Naccache, P.H.   +2 more
core   +1 more source

Basal and inducible anti-inflammatory epoxygenase activity in endothelial cells [PDF]

, 2014
The roles of CYP lipid-metabolizing pathways in endothelial cells are poorly understood. Human endothelial cells expressed CYP2J2 and soluble epoxide hydrolase (sEH) mRNA and protein.
Ara A. Askari, Askari, Baum, Bishop-Bailey, Bouis, Bystrom, Bystrom, Campbell, Capdevila, Darryl C. Zeldin, David Bishop-Bailey, Deng, Falck, Fang, Fred B. Lih, Hercule, Hwang, Imig, Jung, Lauterbach, Lee, Loppnow, Luo, Matthew L. Edin, Morisseau, Piqueras, Piqueras, Revermann, Schuchardt, Scott Thomson, Spiecker, Vinay, Zeldin, Zeldin, Zeldin, Zhang   +35 more
core   +1 more source

Optimization of protein removal process of Lonicera japonica polysaccharide and its immunomodulatory mechanism in cyclophosphamide‐induced mice by metabolomics and network pharmacology

Food Science &Nutrition, Volume 11, Issue 1, Page 364-378, January 2023., 2023
In this paper, the best protein removal method of Lonicera japonica polysaccharide was determined and its process was optimized by response surface method. Pharmacological experiments showed that polysaccharides had therapeutic effect on immunodeficiency mice induced by cyclophosphamide (CTX).
Jie Ding, Haitao Du, Haining Tan, Jing Li, Lingna Wang, Li Li, Yongqing Zhang, Yuhong Liu   +7 more
wiley   +1 more source

The Polyunsaturated Fatty Acids Arachidonic Acid and Docosahexaenoic Acid Induce Mouse Dendritic Cells Maturation but Reduce T-Cell Responses In Vitro. [PDF]

PLoS ONE, 2015
Long-chain polyunsaturated fatty acids (PUFAs) might regulate T-cell activation and lineage commitment. Here, we measured the effects of omega-3 (n-3), n-6 and n-9 fatty acids on the interaction between dendritic cells (DCs) and naïve T cells. Spleen DCs
Johan A Carlsson, Agnes E Wold, Ann-Sofie Sandberg, Sofia M Östman   +3 more
doaj   +1 more source