Results 91 to 100 of about 5,117,744 (378)
These study underscores the pivotal role of neutrophil‐derived myeloid‐related protein 14 (MRP14) in the pathophysiology of acute ischemic stroke (AIS). MRP14 not only disrupts mitochondrial function, thereby inhibiting microglial phagocytosis of neutrophils, but also activates microglial pyroptosis, exacerbating neuroinflammation following AIS ...
Huijuan Jin+10 more
wiley +1 more source
Anti-thrombotic effects of omega-3 (n-3) fatty acids are believed to be due to their ability to reduce arachidonic acid levels. Therefore, weanling rats were fed n-3 acids in the form of linseed oil (18:3n-3) or fish oil (containing 20:5n-3 and 22:6n-3 ...
ML Garg, AB Thomson, MT Clandinin
doaj
Pharmacometabolomic mapping of early biochemical changes induced by sertraline and placebo. [PDF]
In this study, we characterized early biochemical changes associated with sertraline and placebo administration and changes associated with a reduction in depressive symptoms in patients with major depressive disorder (MDD).
Bogdanov, MB+11 more
core +2 more sources
HPD is identified as an RNA‐binding protein that promotes mRNA translation by binding to RRACH motifs via its double‐stranded RNA‐binding domains. This RNA‐binding activity critically sustains glycolysis in ovarian cancer cells. Disrupting HPD's RNA‐binding function effectively suppresses tumor growth and enhances therapeutic sensitivity, highlighting ...
Fei Xie+21 more
wiley +1 more source
KRAS/ABHD17C/ALOX15B Axis Promotes Pancreatic Cancer Progression via Ferroptosis Evasion
Phosphorylation of ABHD17C induced by KRASmut/ERK signaling facilitates ALOX15B depalmitoylation and degradation via the CUL4/DDB1/DCAF10 complex, thereby enabling KRASmut‐PDAC cell to evade ferroptosis. Methyl protodioscin inhibits KRASmut‐PDAC progression by disrupting the ABHD17C/ALOX15B interaction and inducing ferroptosis, which represents a ...
Man Li+12 more
wiley +1 more source
Systematic review of fatty acid composition of human milk from mothers of preterm compared to full-term infants [PDF]
Background: Fatty acid composition of human milk serves as guidance for the composition of infant formulae. The aim of the study was to systematically review data on the fatty acid composition of human milk of mothers of preterm compared to full-term ...
Aggett PJ+22 more
core +1 more source
Covalent organic framework (COF)‐reuterin induces trained immunity in tumor‐associated macrophages, promoting the generation of nitric oxide and reactive oxygen species, thereby enhancing the antitumor immune response. Additionally, COF‐Reuterin directly kills tumor cells while simultaneously eradicating pathogenic intratumoural bacteria.
Jian‐Gang Zhang+8 more
wiley +1 more source
The influence of exogenous cholesterol on hepatic lipid composition of the rat*
Rats were fed diets containing cottonseed oil and/or cholesterol, cholic acid, methyl esters of long-chain fatty acids, and tocopherol. Livers, hearts, and aortas were examined histologically; liver lipids were fractionated by silicic acid chromatography;
Robert J. Morin+3 more
doaj
Arachidonic acid in cellular activation [PDF]
The paper by Huang et al in this issue of Kidney International addresses the interesting and still unsettled question as to whether arachidonic acid (AA), in and of itself, is a specific pathophysiologic "mediator" of injury, independently of its further transformation into oxygenated derivatives1.
openaire +2 more sources
Iron‐induced lipid peroxidation of phosphatidylethanolamine (PE) species is the key driver of ferroptosis. The authors discovered that PHOSPHO1 lowers the level of PE in retinal pigment epithelial cells thus reducing the formation of lipid peroxides. Lowering PE levels can also prevent the creation of autolysosomes, reduce the production of free iron ...
Zhiyang Chen+19 more
wiley +1 more source