Results 11 to 20 of about 5,158 (166)

Beyond PEGylation: Archaeal Lipids for Long‐Circulating Liposomes

Advanced NanoBiomed Research
The growing concerns regarding the immunogenicity of polyethylene glycol (PEG) have prompted the search for alternative excipients that can prolong circulation in parenteral drug delivery.
Viktor Sedlmayr, Andreas D. Meid, Eric Mühlberg, Manuel Ben Böhmann, Julian Quehenberger, David Wurm, Mikko Gynther, Oliver Spadiut, Gert Fricker, Philipp Uhl   +9 more
doaj   +3 more sources

Biosynthesis of archaeal membrane ether lipids [PDF]

Frontiers in Microbiology, 2014
A vital function of the cell membrane in all living organism is to maintain the membrane permeability barrier and fluidity. The composition of the phospholipid bilayer is distinct in archaea when compared to bacteria and eukarya.
Samta eJain, Samta eJain, Antonella eCaforio, Arnold J. M. Driessen   +3 more
doaj   +5 more sources

A comprehensive database for high-throughput identification of archaeal lipids using high-resolution mass spectrometry [PDF]

Nature Communications
Archaeal membrane lipids are markedly distinct from those in bacteria and eukaryotes, serving as biomarkers for unraveling their ecological and biogeochemical roles.
Fengfeng Zheng, Wenyong Yao, Wei He, Wan Zhang, Yufei Chen, Huahui Chen, Zhirui Zeng, Xiao-Lei Liu, Su Ding, Yanhong Zheng, Linan Huang, Yuanqing Zhu, Chuanlun Zhang   +12 more
doaj   +2 more sources

Engineering archaeal membrane‐spanning lipid GDGT biosynthesis in bacteria: Implications for early life membrane transformations [PDF]

mLife
Eukaryotes are hypothesized to be archaeal–bacterial chimeras. Given the different chemical structures of membrane phospholipids in archaea and bacteria, transformations of membranes during eukaryogenesis that led to the bacterial‐type membranes of ...
Huahui Chen, Fengfeng Zheng, Xi Feng, Zijing Huang, Wei Yang, Chuanlun Zhang, Wenbin Du, Kira S. Makarova, Eugene V. Koonin, Zhirui Zeng   +9 more
doaj   +2 more sources

Uncovering the prevalence, key biogenesis enzymes, and biological significance of archaeal lipoproteins [PDF]

Nature Communications
Lipid-anchored proteins are integral components of cell surfaces. In bacteria, lipidation of proteins with a conserved lipobox motif ([L/V/I]−3 [A/S/T/V/I]−2 [G/A/S]−1 [C]+1) is catalyzed by prolipoprotein diacylglyceryl transferase (Lgt).
Yirui Hong, Kira S. Makarova, Andy A. Garcia, Rachel Xu, Friedhelm Pfeiffer, Paula V. Welander, Mechthild Pohlschroder   +6 more
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Microbial decomposer diversity and metabolic function during the decomposition of brine shrimp carcasses in a saline lake [PDF]

Microbiome
Background Decomposition of brine shrimp carcasses has a crucial role in carbon cycling of saline lakes, yet the microbial dynamics remain poorly understood.
Lei Gao, Bao-Zhu Fang, Jian Yang, Zheng-Han Lian, Ying Chen, Osama Abdalla Abdelshafy Mohamad, Qing-Yu Xu, Yong-Hong Liu, Dildar Wu, Yang Yuan, Rashidin Abdugheni, Meng-Meng Li, Pandeng Wang, Maite Ortúzar, Xin-Yao Li, Jian-Rong Huang, Lan Liu, Hong-Chen Jiang, Wensheng Shu, Brian P. Hedlund, Wen-Jun Li, Jian-Yu Jiao   +21 more
doaj   +2 more sources

Impacts of temperature and pH on the distribution of archaeal lipids in Yunnan hot springs, China [PDF]

Frontiers in Microbiology, 2013
In culture experiments and many low temperature environments, the distribution of isoprenoid glycerol dialkyl glycerol tetraethers (GDGTs) commonly shows a strong correlation with temperature; however, this is often not the case in hot springs.
Weiyan eWu, Chuanlun eZhang, Chuanlun eZhang, Huanye eWang, Huanye eWang, Liu eHe, Wenjun eLi, Hailiang eDong, Hailiang eDong   +8 more
doaj   +2 more sources

Lipids of Archaeal Viruses [PDF]

Archaea, 2012
Archaeal viruses represent one of the least known territory of the viral universe and even less is known about their lipids. Based on the current knowledge, however, it seems that, as in other viruses, archaeal viral lipids are mostly incorporated into membranes that reside either as outer envelopes or membranes inside an icosahedral capsid. Mechanisms
Bamford Dennis, Roine Elina
openaire   +3 more sources

Nanoarchaeosomes for synergistic photochemotherapy in triple-negative breast cancer [PDF]

Scientific Reports
Triple-negative breast cancer (TNBC) poses significant therapeutic challenges due to the lack of targetable receptors and the systemic toxicity associated with conventional treatments such as surgery, radiotherapy, and chemotherapy.
Shaik Sameer Basha, Sachin Thomas, Subastri Ariraman, Renugaa Suresh Babu, Poornima Budime Santhosh, Lyubomir Stoychev, Julia Genova, Albena Daskalova, Bhagyashree Bhoir, Vimalraj Selvaraj, Swathi Sudhakar   +10 more
doaj   +2 more sources

Non-Polar Lipids as Regulators of Membrane Properties in Archaeal Lipid Bilayer Mimics [PDF]

International Journal of Molecular Sciences, 2021
The modification of archaeal lipid bilayer properties by the insertion of apolar molecules in the lipid bilayer midplane has been proposed to support cell membrane adaptation to extreme environmental conditions of temperature and hydrostatic pressure.
Marta Salvador-Castell, Nicholas Brooks, Roland Winter, Judith Peters, Philippe Oger   +4 more
openaire   +4 more sources