Results 11 to 20 of about 252,711 (203)

Biosynthesis of archaeal membrane ether lipids [PDF]

Frontiers in Microbiology, 2014
A vital function of the cell membrane in all living organism is to maintain the membrane permeability barrier and fluidity. The composition of the phospholipid bilayer is distinct in archaea when compared to bacteria and eukarya.
Samta eJain, Samta eJain, Antonella eCaforio, Arnold J. M. Driessen   +3 more
doaj   +10 more sources

Structure–function relationships in pure archaeal bipolar tetraether lipids [PDF]

Chemical Science, 2023
A series of archaeal bipolar glycerol dialkyl glycerol tetraether (GDGT) lipids were synthesized. Structural properties of self-assembled structures of GDGTs were studied and related to functional behavior such as membrane fusion.
Ahanjit Bhattacharya, Isaac D. Falk, Frank R. Moss, Thomas M. Weiss, Khoi N. Tran, Noah Z. Burns, Steven G. Boxer   +6 more
openaire   +4 more sources

Archaeal lipids in oral delivery of therapeutic peptides [PDF]

European Journal of Pharmaceutical Sciences, 2017
Archaea contain membrane lipids that differ from those found in the other domains of life (Eukarya and Bacteria). These lipids consist of isoprenoid chains attached via ether bonds to the glycerol carbons at the sn-2,3 positions. Two types of ether lipids are known, polar diether lipids and bipolar tetraether lipids. The inherent chemical stability and
Ann-Christin Jacobsen, Sara M Jensen, Gert Fricker, Martin Brandl, Alexander H. Treusch   +4 more
openaire   +5 more sources

Archaeal tetraether bipolar lipids: Structures, functions and applications

Biochimie, 2009
Archaea have developed specific tools permitting life under harsh conditions and archaeal lipids are one of these tools. This microreview describes the particular features of tetraether-type archaeal lipids and their potential applications in biotechnology.
Jacquemet, Alicia, Barbeau, Julie, Lemiègre, Loïc, Benvegnu, Thierry   +3 more
openaire   +4 more sources

Optimizing Archaeal Lipid Biosynthesis in Escherichia coli [PDF]

ACS Synthetic Biology
Membrane lipid chemistry is remarkably different in archaea compared with bacteria and eukaryotes. In the evolutionary context, this is also termed the lipid divide and is reflected by distinct biosynthetic pathways. Contemporary organisms have almost without exception only one type of membrane lipid.
Mirthe Hoekzema, Jiayi Jiang, Arnold J. M. Driessen   +2 more
openaire   +4 more sources

Beyond PEGylation: Archaeal Lipids for Long‐Circulating Liposomes

Advanced NanoBiomed Research
The growing concerns regarding the immunogenicity of polyethylene glycol (PEG) have prompted the search for alternative excipients that can prolong circulation in parenteral drug delivery.
Viktor Sedlmayr, Andreas D. Meid, Eric Mühlberg, Manuel Ben Böhmann, Julian Quehenberger, David Wurm, Mikko Gynther, Oliver Spadiut, Gert Fricker, Philipp Uhl   +9 more
doaj   +2 more sources

Engineering Escherichia coli for the production of saturated archaeal lipids

Metabolic Engineering
Archaeal membrane phospholipids have a different chemical composition than the phospholipids found in bacteria and eukaryotes. Typically, in archaea, phospholipids consist of saturated isoprenoid chains that are ether-bonded to glycerol 1-phosphate whereas in bacteria and eukaryotes, the main phospholipids are fatty acyl chains ester-bonded to glycerol
Jiayi Jiang, Mirthe Hoekzema, Ruben Andringa, Adriaan J. Minnaard, Arnold J.M. Driessen   +4 more
openaire   +4 more sources

Bilayer-forming lipids enhance archaeal monolayer membrane stability

International Journal of Molecular Sciences
Abstract Archaeal membranes exhibit remarkable stability under extreme environmental conditions, a feature attributed to their unique lipid composition. While it is widely accepted that tetraether lipids confer structural integrity by forming monolayers, the role of bilayer-forming diether lipids in membrane stability remains unclear ...
M. Saracco, P. Schaeffer, M. Tourte, S.-V. Albers, Y. Louis, J. Peters, B. Demé, S. Fontanay, P. Oger   +8 more
openaire   +4 more sources

Archaeal Lipids Regulating the Trimeric Structure Dynamics of Bacteriorhodopsin for Efficient Proton Release and Uptake. [PDF]

Int J Mol Sci, 2022
S-TGA-1 and PGP-Me are native archaeal lipids associated with the bacteriorhodopsin (bR) trimer and contribute to protein stabilization and native dynamics for proton transfer.
Chen S, Ding X, Sun C, Wang F, He X, Watts A, Zhao X.   +6 more
europepmc   +2 more sources

Archaeal Lipids: Extraction, Separation, and Identification via Natural Product Chemistry Perspective. [PDF]

Int J Mol Sci
Archaeal lipids, defining a primordial life domain alongside Bacteria and Eukarya, are distinguished by their unique glycerol-1-phosphate backbone and ether-linked isoprenoid chains.
Li T, Luo Y, Liu C, Lu X, Feng B.
europepmc   +2 more sources