Results 71 to 80 of about 751,174 (286)

Spatial patterns of Geological Culture Villages (Towns) and their influential factors in China

Heritage Science
Geological Culture Villages Towns (GCV(T)s) serve as rich repositories of geological resources, embodying significant historical and cultural values that mirror the dynamic interplay between Earth's evolution and human societies. Despite their importance,
Yunxing Zhang, Zhenyu Zhang, Chenchen Lu, Meiyu Yang, Zhengyu Zhao, Cuihua Gu   +5 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Ground-Motion Intensity Measures for the Seismic Response of the Roof-Isolated Large-Span Structure

Buildings
Ground-motion intensity measures (IMs), which quantify and describe the characteristics of earthquake ground motion, are of utmost importance in the assessment of seismic risk and the design of resilient structures with large spans.
Wei Zhen, Yikun Qiu, Yanhua Zhang, Wei Li   +3 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Architectural authorship in generative design [PDF]

, 2007
The emergence of evolutionary digital design methods, relying on the creative generation of novel forms, has transformed the design process altogether and consequently the role of the architect.
Theodoropoulou, A.
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Analysis of the current state of the compositional ensemble of Yerevan's central square: challenges and proposed solutions

Budownictwo i Architektura
This article explores contemporary challenges related to the spatial environment of public squares, focusing specifically on the architectural ensemble of Yerevan’s Republic Square.
Zhora Sagaryan, Karen Azatyan
doaj   +1 more source

On Tools and Representation

Megaron, 2016
Technology and tools have contributed a great deal to human evolution in terms of how we think, live, and work. The design domain has also witnessed and experienced changes in technology and design tools.
Betül Orbey, Sinan Mert Şener
doaj   +1 more source

Investigation of Diagrid Structures Over Gherkin Tower

Proceedings of the International Conference of Contemporary Affairs in Architecture and Urbanism-ICCAUA, 2020
21st.Century witnesses enormous technological development effecting Architecture also: New and improved building materials and construction techniques, highly innovative development of structural systems utilizing advanced computer software leads to ...
Mustafa Küçük, Halil Ibrahim Arslan
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source