Results 81 to 90 of about 428,058 (275)

Software architectures and Open Source Software: Where can research leverage the most? [PDF]

, 2001
Software architectures have been playing a central role in software engineering research for some years now. They are considered of pivotal importance in the success of complex software systems development.
Arief, B., Gacek, C., Lawrie, T.
core  

Rationale Management Challenges in Requirements Engineering [PDF]

, 2010
Rationale and rationale management have been playing an increasingly prominent role in software system development mainly due to the knowledge demand during system evaluation, maintenance, and evolution, especially for large and complex systems.
Avgeriou, Paris,, He, Keqing,, Liang, Peng,   +2 more
core   +3 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Form generation and modelling of complex spatial solutions in sacral construction under the influence of modern structural and building technologies and calculation methodologies [PDF]

Дороги і мости
ntroduction. The article addresses the issue of designing complex architectural forms in modern sacred architecture, with a focus on structural feasibility and engineering analysis.
Alexei Yaschenko, Serhii Kelba
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

The Impact of AI-Powered Platforms and Tools on Architectural Education

Journal of Architecture, Art & Humanistic Science
The integration of artificial intelligence AI into educational processes has been a topic of increasing interest across various disciplines. In the field of architecture, where creativity, design thinking, and technical proficiency are paramount, the use
Assist.Prof. Dr. Maha Fawzy Aly Anber 1Associate Professor of Architecture- Architectural engineering department- Higher Institute of Engineering in Shorouk City- Shorouk Academy- Egypt;
doaj   +1 more source

Visualisation of semantic architectural information within a game engine environment [PDF]

, 2010
Because of the importance of graphics and information within the domain of architecture, engineering and construction (AEC), an appropriate combination of visualisation technology and information management technology is of utter importance in the ...
De Meyer, Ronald, Pauwels, Pieter, Van Campenhout, Jan   +2 more
core  

From the Class Room to the Mechanical Room: How Architectural Engineering Students Benefit from a Partnership Between the University’s Faculty and Facilities Engineers [PDF]

, 2017
Values at Work Series: Facilities Services developed our core values of Service, Integrity, Teamwork, Excellence, and Stewardship (collectively referred to as SITES) based on the way we approach our work.
Illanes, Laura
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Semantic model-driven development of service-centric software architectures [PDF]

, 2007
Service-oriented architecture (SOA) is a recent architectural paradigm that has received much attention. The prevalent focus on platforms such as Web services, however, needs to be complemented by appropriate software engineering methods.
Barrett, Ronan, Pahl, Claus
core