Results 61 to 70 of about 1,565,190 (299)
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Miranda: Revue Pluridisciplinaire du Monde Anglophone, 2011 Intensive mobility of the factors of production (capital and work) is a major feature of the United States. Based on a geographical analysis, this paper describes the way in which the geographical mobility of capital (considered here as a driving force ...
Frédéric Leriche
doaj +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
NANO, 2020 Lasting eighteen hours and featuring umpteen locations, Twin Peaks: The Return spreads out across time and space in a manner rarely seen in David Lynch’s work. In short, it sprawls. This article explores how sprawl might be a useful term through which to
Richard Martin
doaj
Innovation in English Gothic Architecture: Risks, Impediments, and Opportunities
British Art Studies, 2017 This essay considers some of the practical and human situations that affected innovation in English medieval architecture. These included the scale of the Norman inheritance, the process of incremental construction, and the personal relationships that ...
Roger Stalley
doaj +1 more source
AgileDCN: An Agile Reconfigurable Optical Data Center Network Architecture [PDF]
, 2020 Dinh Danh Le +5 more
openalex +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source