Results 71 to 80 of about 1,565,190 (299)
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Discussion on Integration of Data Warehouse and Big Data
Dianxin kexue, 2015 In view of the traditional enterprise couldn't use such unstructured data efficiently,a big data solutions based on integration of data warehouse and big data was discussed.Based on the theory of data warehouse construction and architecture of the next ...
Juan Yu
doaj
On the Road to Holistic Decision Making in Adaptive Security [PDF]
Technology Innovation Management Review, 2013 Security is a critical concern in today's software systems. Besides the interconnectivity and dynamic nature of network systems, the increasing complexity in modern software systems amplifies the complexity of IT security.
Mahsa Emami-Taba +2 more
doaj
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
The ethnological and anthropological study of Bežanija at the start of the 21st century: The impact of urban development on boundaries and the perception of a neighbourhood [PDF]
Nasleđe, 2020 Being one of the older settlements in the present-day City of Belgrade, more precisely the municipality of Novi Beograd, Bežanija is a place boasting rich historical, urban planning, and architectural features.
Dražeta Bogdan D., Stankić Mladen D.
doaj
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
1951-1952 competition for the Monument to the fallen Jewish soldiers and victims of fascism in the Sephardi cemetery in Belgrade [PDF]
Nasleđe, 2020 In their wish to preserve the memory to the compatriots who lost their lives in the Holocaust, the Jewish community in Yugoslavia started erecting monuments to Jewish civil victims and fallen soldiers as early as the first few post-WWII years.
Stipić Davor
doaj
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Ludwig Hilberseimer and Metropolisarchitecture: The Analogue, the Blasé Attitude, the Multitude
Arts, 2018 This article close-reads Modernist architect Ludwig Hilberseimer’s early architectural projects, which employed a language of uniform fenestration, repetition and geometrically reduced typical forms, as embodying Georg Simmel’s blasé ...
Cameron McEwan
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source