Results 81 to 90 of about 3,324,545 (359)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Digital Light Processing of 2D Lattice Composites for Tunable Self‐Sensing and Mechanical Performance

Advanced Engineering Materials, EarlyView., 2023
The study presents the mechanical and in situ sensing performance of digital light processing‐enabled 2D lattice nanocomposites under monotonic tensile and repeated cyclic loading, and provides guidelines for the design of architectures suitable for strain sensors and smart lightweight structures.
Omar Waqas Saadi, Mohammed Ayaz Uddin, Andreas Schiffer, Shanmugam Kumar   +3 more
wiley   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Creep Characterization of Inconel 718 Lattice Metamaterials Manufactured by Laser Powder Bed Fusion

Advanced Engineering Materials, EarlyView., 2023
Herein, the creep characteristics of additively manufactured Inconel 718 metamaterials are investigated. The creep behavior of metamaterials and the effects of microstructural defects are assessed, and the microstructure defects are accurately captured using Kachanov's creep damage model.
Akash Singh Bhuwal, Yong Pang, Ian Maskery, Ian Ashcroft, Wei Sun, Tao Liu   +5 more
wiley   +1 more source

On Assessing the Complexity of Software Architectures [PDF]

Proceedings of the 3rd International Software Architecture Workshop (ISAW3), pp.163-166, ACM SIGSOFT, November 1998, 2001
This paper proposes some new architectural metrics which are appropriate for evaluating the architectural attributes of a software system. The main feature of our approach is to assess the complexity of a software architecture by analyzing various types of architectural dependences in the architecture.
arxiv  

Molecular Architecture of the Mouse Nervous System

Cell, 2018
The mammalian nervous system executes complex behaviors controlled by specialised, precisely positioned and interacting cell types. Here, we used RNA sequencing of half a million single cells to create a detailed census of cell types in the mouse nervous
Amit Zeisel, Hannah Hochgerner, P. Lönnerberg, A. Johnsson, Fatima Memic, Job van der Zwan, M. Häring, Emelie Braun, Lars E. Borm, Gioele La Manno, S. Codeluppi, A. Furlan, Kawai Lee, N. Skene, K. Harris, J. Hjerling-Leffler, E. Arenas, P. Ernfors, Ulrika Marklund, S. Linnarsson   +19 more
semanticscholar   +1 more source

This Is the Age of the Architectural, Not Architecture.

, 2017
This is the age of the architectural, not architecture. The architectural is a praxis for making the social by covering and uncovering black boxes of flows and intensities. Architecture is ideology! The architectural in “architectural research” is not a descriptor pertaining to research in, for, or through architecture.
openaire   +3 more sources

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

A Variational Beam Model for Failure of Cellular and Truss‐Based Architected Materials

Advanced Engineering Materials, EarlyView., 2023
Herein, a versatile and efficient beam modeling framework is developed to predict the nonlinear response and failure of cellular, truss‐based, and woven architected materials. It enables the exploration of their design space and the optimization of their mechanical behavior in the nonlinear regime. A variational formulation of a beam model is presented
Konstantinos Karapiperis, Kaoutar Radi, Zifan Wang, Dennis M. Kochmann   +3 more
wiley   +1 more source

Analysis of Fault Tolerant Multi-stage Switch Architecture for TSN [PDF]

arXiv, 2022
We conducted the feasibility analysis of utilizing a highly available multi-stage architecture for TSN switches used for sending high priority, mission-critical traffic within a bounded latency instead of traditional single-stage architectures. To verify the TSN functionality, we implemented the 'strict priority' feature.
arxiv