Results 81 to 90 of about 11,057,218 (281)

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

University of Melbourne, School of Architecture : design 2, 1964

, 1964
Cover titleUniversity of Melbourne, School of Architecture -- coverIncomplete, contains no student work - some pages left empty [not all ...
University of Melbourne. Faculty of Architecture
core  

Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling

Advanced Science, EarlyView.
Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...
Fangzi Zha, Di Feng, Ziru Xue, Zhiying Liu, Xiaochen Lin, Zhe Wang, Ling Xu, Jasper Fuk Woo Chan, Martin Cheung, Michael Shing Yan Huen, Yusong Guo, Kui Ming Chan, Yun Liu, Bo Gao   +13 more
wiley   +1 more source

Mindful innovation: the future of architecture in the age of AI

ESTOA: Revista de la Facultad de Arquitectura y Urbanismo de la Universidad de Cuenca
A critical and forward-looking perspective on the role of artificial intelligence (AI) in architecture is proposed. Rather than adopting technophobic or technocratic positions, it advocates for a “mindful innovation” that integrates AI’s capabilities ...
Karla Saldaña
doaj   +1 more source

Transposable Element Dynamics Drive the Genomic Evolution and Phenotypic Diversification of Allotetraploid Common Carp

Advanced Science, EarlyView.
By integrating 516 whole‐genome resequencing datasets and 236 transcriptomes of allotetraploid common carp, this study establishes the first population‐scale atlas of transposable element (TE) variation in teleost species. TE bursts, relaxed purifying selection, and lineage‐specific loss of ancient insertions shape genome evolution and phenotypic ...
Shuimu Hu, Zhou Jiang, Lin Chen, Gowena Ling Yi Goh, Weijing Li, Qian He, Xintong Chen, Rui Li, Yuxuan Liu, Ning Li, Tao Zhou, Peng Xu   +11 more
wiley   +1 more source

Perception to Virtual Design Studio in the Initiation, Realization and Reflection Phase: The Faculties and Students Perspective

Journal of Asian Architecture and Building Engineering
The study examines virtual design studio pedagogy in regional settings, providing a comprehensive understanding of the experiences of faculty members and students as they adapted to the virtual design studio due to the COVID-19 pandemic.
Asif R. Khan, N. Lakshmi Thilagam
doaj   +1 more source

Adaptive Network Stabilization Despite Profound Structural Reorganization in Human Organotypic Cultures

Advanced Science, EarlyView.
Adult human organotypic cortical slices undergo marked neuronal loss, laminar disruption, and glial activation, yet their network activity progressively stabilizes after a variable period. Electrophysiology, longitudinal calcium imaging, and quantitative histology show that structurally remodeled human circuits show adaptive capacity resulting in ...
Estilla Zsófia Tóth, Rebeka Stelcz, Réka Bod, Ábel Petik, Eszter Juhász, Kinga Tóth, Liza Szalai, Nour Essam, Fanni Somogyi, Beatrix Kovács, Amirmahdi Mojtahedzadeh, Attila György Bagó, Loránd Erőss, Péter Orbay, Johanna Petra Szabó, Dániel Fabó, Boglárka Hajnal, Bence Rácz, Daniel Hillier, István Ulbert, Lucia Wittner   +20 more
wiley   +1 more source

Correction: Khonsari, T. Community Action: An Architecture and Design Pedagogy. Architecture 2025, 5, 115

Architecture
The Institutional Review Board Statement and Informed Consent Statement need to be updated in the original publication [...]
Torange Khonsari
doaj   +1 more source

Studio of Architecture and Its Relevance in Design Pedagogy

RUANG-SPACE, Jurnal Lingkungan Binaan (Space : Journal of the Built Environment), 2023
I Ketut Mudra, Kadek Edi Saputra, Ni Made Swanendri, Gusti Ayu Made Suartika   +3 more
openaire   +1 more source

Collaborative pedagogy in architectural design studio: A case study in applying collaborative design

Alexandria Engineering Journal, 2019
Architectural design has always been a collaborative process that involves participatory practice. It requires experienced individuals working together; this includes architects, engineers and clients to achieve a singular goal. Therefore, there has been increased interest in achieving a collaborative design studio and developing architecture students’
Maii Emam, Dina Taha, Zeyad ElSayad
openaire   +2 more sources