Results 91 to 100 of about 830,767 (408)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Comprehensive study of old ice ridges in the Arctic Ocean

Лëд и снег, 2020
In May 2015, a comprehensive study of an old ice ridge was carried out to the north of Bennett Island in the East-Siberian Sea with application of water thermal drilling, tachometric and sonar surveys, video survey by the underwater device and methods ...
Roman B. Guzenko, Yevgeny U. Mironov, Victor V. Kharitonov, Stepan V. Khotchenkov, Ruslan I. May, Viktor S. Porubaev, Sergey M. Кovalеv, Konstantin А. Kornishin, Yaroslav О. Efimov   +8 more
doaj  

One Arctic [PDF]

Science, 2015
This month, the United States takes over the chairmanship of the Arctic Council, a position it last held in 1998. Since then, global interest in the Arctic has increased, and the council has evolved considerably. What has spurred that interest, and what will the council focus on under U.S. leadership?
openaire   +2 more sources

Reviews and syntheses: Arctic fire regimes and emissions in the 21st century

Biogeosciences, 2021
. In recent years, the pan-Arctic region has experienced increasingly extreme fire seasons. Fires in the northern high latitudes are driven by current and future climate change, lightning, fuel conditions, and human activity.
J. McCarty, J. Aalto, Ville-Veikko Paunu, S. Arnold, S. Eckhardt, Z. Klimont, J. Fain, N. Evangeliou, A. Venäläinen, N. Tchebakova, E. Parfenova, K. Kupiainen, A. Soja, Lin Huang, Simon Wilson   +14 more
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Potential for flexible lactate shuttling between astrocytes and neurons to mitigate against diving-induced hypoxia

Frontiers in Neuroanatomy
For most non-diving mammals, lack of O2 (hypoxia) has detrimental effects on brain function. Seals, however, display a series of systemic, cellular, and molecular adaptations that enable them to tolerate repeated episodes of severe hypoxia.
Chiara Ciccone, Sari Elena Dötterer, Sigrid Vold Jensen, Cornelia Geßner, Alexander C. West, Shona H. Wood, David G. Hazlerigg, Lars P. Folkow   +7 more
doaj   +1 more source

Seasonal variation of the transport of black carbon aerosol from the Asian continent to the Arctic during the ARCTAS aircraft campaign [PDF]

, 2011
Extensive measurements of black carbon (BC) aerosol were conducted in and near the North American Arctic during the Arctic Research of the Composition of the Troposphere from Aircraft and Satellites (ARCTAS) aircraft campaign in April and June-July 2008.
Blake, DR, Diskin, G, Fuelberg, HE, Koike, M, Kondo, Y, Matsui, H, Moteki, N, Sahu, LK, Sessions, WR, Takegawa, N, Wisthaler, A, Zhao, Y   +11 more
core   +1 more source

Borealization of the Arctic Ocean in Response to Anomalous Advection From Sub-Arctic Seas

Frontiers in Marine Science, 2020
An important yet still not well documented aspect of recent changes in the Arctic Ocean is associated with the advection of anomalous sub-Arctic Atlantic- and Pacific-origin waters and biota into the polar basins, a process which we refer to as ...
I. Polyakov, M. Alkire, B. Bluhm, K. Brown, E. Carmack, M. Chierici, S. Danielson, I. Ellingsen, E. Ershova, K. Gårdfeldt, R. Ingvaldsen, A. Pnyushkov, D. Slagstad, P. Wassmann   +13 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Development of the technology of a new flour culinary fish product enriched with iodine of the White Sea kelp

Vestnik MGTU
The range of fish culinary products has been selected based on the analysis of consumer motivation in Murmansk and current trends in the development of the regional fish culinary products market.
Savkina K. N., Cshetinsky V. V., Tihonova P. A., Shokina Yu. V.   +3 more
doaj   +1 more source