Results 101 to 110 of about 819,301 (403)

A circumpolar perspective on fluvial sediment flux to the Arctic ocean [PDF]

, 2002
Quantification of sediment fluxes from rivers is fundamental to understanding land‐ocean linkages in the Arctic. Numerous publications have focused on this subject over the past century, yet assessments of temporal trends are scarce and consensus on ...
Holmes, Robert M., McClelland, James W., Peterson, Bruce J.   +2 more
core   +2 more sources

The tipping times in an Arctic sea ice system under influence of extreme events

, 2020
In light of the rapid recent retreat of Arctic sea ice, the extreme weather events triggering the variability in Arctic ice cover has drawn increasing attention.
Duan, Jinqiao, Fu, Ling, Wiggins, Stephen, Yang, Fang, Zheng, Yayun   +4 more
core   +1 more source

Polychlorinated biphenyls in air and water of the North Atlantic and Arctic Ocean. [PDF]

, 2008
Air and seawater samples were collected on board the R/V Polarstern during a scientific expedition from Germany to the Arctic Ocean during June–August 2004.
Dachs, Jordi, Gioia, Rosalinda, Hand, Ines, Jones, Kevin C., Lakaschus, Soenke, Lohmann, Rainer, Schulz-Bull, Detlef, Temme, Christian   +7 more
core   +3 more sources

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Informativeness (information-bearing) of hydrometeorological and astrogeophysical factors in the problem of describing interannual fluctuations of the Greenland Sea ice coverage

Лëд и снег, 2021
The interannual changes in ice coverage in the Greenland Sea for the winter (December–April), spring (May– June), summer (July–September), and autumn (October–November) seasons for the period 1950-2018 are considered.
N. A. Viazigina, L. A. Timokhov, E. S. Egorova, A. V. Yulin   +3 more
doaj   +1 more source

The International Bathymetric Chart of the Arctic Ocean Version 4.0

Scientific Data, 2020
Bathymetry (seafloor depth), is a critical parameter providing the geospatial context for a multitude of marine scientific studies. Since 1997, the International Bathymetric Chart of the Arctic Ocean (IBCAO) has been the authoritative source of ...
M. Jakobsson, L. Mayer, Caroline Bringensparr, C. F. Castro, Rezwan Mohammad, Paul G. Johnson, T. Ketter, D. Accettella, D. Amblas, L. An, J. Arndt, M. Canals, J. L. Casamor, N. Chauché, B. Coakley, S. Danielson, M. Demarte, M. Dickson, B. Dorschel, J. Dowdeswell, Simon Dreutter, Alice C. Frémand, Dana Gallant, J. Hall, Laura Hehemann, Hanne Hodnesdal, Jongkuk Hong, R. Ivaldi, E. Kane, I. Klaucke, D. Krawczyk, Y. Kristoffersen, Boele R. Kuipers, R. Millan, G. Masetti, Mathieu Morlighem, R. Noormets, M. Prescott, M. Rebesco, E. Rignot, I. Semiletov, A. Tate, P. Travaglini, I. Velicogna, P. Weatherall, W. Weinrebe, J. Willis, M. Wood, Y. Zarayskaya, Tao Zhang, M. Zimmermann, K. Zinglersen   +51 more
semanticscholar   +1 more source

Arctic in Rapid Transition (ART) : science plan [PDF]

, 2010
The Arctic is undergoing rapid transformations that have brought the Arctic Ocean to the top of international political agendas. Predicting future conditions of the Arctic Ocean system requires scientific knowledge of its present status as well as a ...
Forest, Alexandre, Forwick, Matthias, Frey, Karen, Mathis, Jeremy, Michel, Christine, Nikolopoulos, Anna, O'Regan, Matt, Peeken, Ilka, Reigstad, Marit, Wegner, Carolyn   +9 more
core  

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Arctic and Sub-Arctic Bees

Nature, 1898
OF the wild bees of Alaska nothing is known, except that several species of humble-bees (Bombus) are common. Consequently, when Mr. Trevor Kincaid wrote me last year that he was going to Alaska, and would collect bees, I was expecting to see, on his return, quite a new bee-fauna.
openaire   +2 more sources

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

Molecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva, Bernardo Orr, Ana Azeredo, Andreia Brandão, Manuel R. Teixeira, Paula Paulo   +5 more
wiley   +1 more source