Results 101 to 110 of about 582,222 (384)
Molecular Oncology, EarlyView.Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric +11 more
wiley +1 more source
Rapid loss of Arctic sea ice [PDF]
arXiv, 2022 Several environmental tipping points and self-reinforcing feedback loops are still disregarded within the frequently used climate models. Thus, existing climate models are not very representative for providing projections of the conditions after the actual environmental tipping points are triggered.
arxiv
A refined method to monitor arousal from hibernation in the European hamster
BMC Veterinary Research, 2021 Background Hibernation is a physiological and behavioural adaptation that permits survival during periods of reduced food availability and extreme environmental temperatures.
Fredrik A. F. Markussen +5 more
doaj +1 more source
Preparing for a Northwest Passage: A Workshop on the Role of New England in Navigating the New Arctic [PDF]
, 2018 Preparing for a Northwest Passage: A Workshop on the Role of New England in Navigating the New Arctic (March 25 - 27, 2018 -- The University of New Hampshire) paired two of NSF\u27s 10 Big Ideas: Navigating the New Arctic and Growing Convergence ...
Ashcraft, Catherine M +13 more
core +1 more source
Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Molecular Oncology, EarlyView.Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren +4 more
wiley +1 more source
Interaction webs in arctic ecosystems: Determinants of arctic change? [PDF]
Ambio, 2017 How species interact modulate their dynamics, their response to environmental change, and ultimately the functioning and stability of entire communities. Work conducted at Zackenberg, Northeast Greenland, has changed our view on how networks of arctic biotic interactions are structured, how they vary in time, and how they are changing with current ...
Schmidt, Niels M. +12 more
openaire +8 more sources
Seasonal distributions of fine aerosol sulfate in the North American Arctic basin during TOPSE [PDF]
, 2003 We used the mist chamber/ion chromatography technique to quantify fine aerosol SO4=(\u3c2.7 μm) in the Arctic during the Tropospheric Ozone Production about the Spring Equinox Experiment (TOPSE) with about 2.5 min time resolution.
Debell, Linsey J +5 more
core +2 more sources
Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM
Molecular Oncology, EarlyView.CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
Bayesian Inference of Spatio-Temporal Changes of Arctic Sea Ice [PDF]
arXiv, 2020 Arctic sea ice extent has drawn increasing interest and alarm from geoscientists, owing to its rapid decline. In this article, we propose a Bayesian spatio-temporal hierarchical statistical model for binary Arctic sea ice data over two decades, where a latent dynamic spatio-temporal Gaussian process is used to model the data-dependence through a logit ...
arxiv