Results 101 to 110 of about 680,036 (364)
Spatial Differentiation of the Economic Structure of the Russian Regions of the Arctic Zone [PDF]
, 2015 The Regions located in the Arctic zone of the Russian Federation implement an important function in the development of an export potential of the country. The richest nature-resource potential of the land and the sea should be considered as the favorable
Baklanov, P. Ya., Moshkov, A. V.
core +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Mechanical properties of high strength steels and weld metals at arctic low temperatures
, 2023 Man-Tai Chen +5 more
openalex +2 more sources
How tropical Pacific surface cooling contributed to accelerated sea ice melt from 2007 to 2012 as ice is thinned by anthropogenic forcing [PDF]
, 2019 Over the past 40 years the Arctic sea ice minimum in September has declined. The period between 2007 and 2012 showed accelerated melt contributed to the record minima of 2007 and 2012.
Baxter, Ian
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
2017 State-of the Science of Dispersants and Dispersed Oil (DDO) in U.S. Arctic Waters: Physical Transport and Chemical Behavior [PDF]
, 2017 Chemical dispersants were employed on an unprecedented scale during the Deepwater Horizon oil spill in the Gulf of Mexico, and could be a response option should a large spill occur in Arctic waters. The use of dispersants in response to that spill raised
Coastal Response Research Center (CRRC)
core +1 more source
Geographic muting of changes in the Arctic sea ice cover [PDF]
, 2010 The seasonal cycle in Arctic sea ice extent is asymmetric. Its amplitude has grown in recent decades as the ice has retreated more rapidly in summer than in winter.
Eisenman, Ian
core +1 more source