Results 61 to 70 of about 212,631 (318)

Associations between stressful life events in childhood/adolescence and adulthood: results from the 7th Tromsø survey

European Journal of Psychotraumatology, 2023
Background: Exposure to highly stressful life events (SLEs), such as accidents, violence, or serious illness, is common. With the accumulation of SLEs, the risk of detrimental somatic and mental health outcomes increases.
Jens C. Thimm, Kamilla Rognmo, Hege Nermo, Jan-Are Kolset Johnsen, Ingunn Skre, Catharina E. A. Wang   +5 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

The prospective development of Climate and Environmental Research Laboratory of AARI, Roshydromet, after gaining the grant of Russian Science Foundation

Лëд и снег, 2015
In November 2010 a new research unit was inaugurated in Arctic and Antarctic Research Institute (St. Petersburg) – Climate and Environmental Research Laboratory (CERL) – that became the first lab in Russia dedicated to the complex studies of ice cores ...
V. Ya. Lipenkov, A. A. Ekaykin, Yu. A. Shibaev, I. A. Alekhina, A. V. Preobrazhenskaya, A. V. Kozachek, D. O. Vladimirova   +6 more
doaj   +1 more source

Thawing Permafrost in Arctic Coastal Communities: A Framework for Studying Risks from Climate Change [PDF]

, 2021
Joan Nymand Larsen, Peter Schweitzer, Khaled Abass, Natalia Doloisio, Susanna Gartler, Thomas Ingeman‐Nielsen, Jón Haukur Ingimundarson, Leneisja Jungsberg, Alexandra Meyer, Arja Rautio, Johanna Scheer, Ulla Timlin, Jean-Paul Vanderlinden, Magali Vullierme   +13 more
openalex   +1 more source

Special Issue: Tracing the Arctic; Arctic Traces

Journal of Northern Studies, 2021
Nowhere on earth is global warming happening as fast today as in the northernmost region. In many cases the situation is acute for both humans and other animals. But it is not only biotopes, but also long-since intertwined systems of nature and culture that are in accelerating processes of change.
openaire   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Inoculation of seed with strains of nitrogen-fixing bacteria (exampled by oats and millet) [PDF]

BIO Web of Conferences
As a result of the conducted researches the expediency and effectiveness of pre-sowing inoculation of seeds of field crops with strains of nitrogen-fixing bacteria has been proved, which allows to increase fodder productivity of oat and pearl millet ...
Osipova Valentina, Platonova Agafya, Khiterkheeva Nadezhda, Drincha Vasily, Dondokov Yuri, Nikolaeva Fevronya, Matveev Ivan, Druzyanova Varvara   +7 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source