Results 241 to 250 of about 37,291 (294)

Photosynthetic light requirement near the theoretical minimum detected in Arctic microalgae. [PDF]

Nat Commun
Hoppe CJM, Fuchs N, Notz D, Anderson P, Assmy P, Berge J, Bratbak G, Guillou G, Kraberg A, Larsen A, Lebreton B, Leu E, Lucassen M, Müller O, Oziel L, Rost B, Schartmüller B, Torstensson A, Wloka J.   +18 more
europepmc   +1 more source

Recapturing the North: Exercises “Eskimo,” “Polar Bear” and “Lemming,” 1945 [PDF]

, 2012
Halliday, Hugh A.
core   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Holocene shifts in marine mammal distributions around Northern Greenland revealed by sedimentary ancient DNA. [PDF]

Nat Commun
Schreiber L, Ribeiro S, Jackson R, Kvorning AB, Nota K, O'Regan M, Pearce C, Seersholm F, Seidenkrantz MS, Zimmermann HH, Lorenzen ED.   +10 more
europepmc   +1 more source

Strawberry Notch 1 Acts as a Transcriptional Regulator Driving Oncogenic Programs in Liver Carcinogenesis

Advanced Science, EarlyView.
This study reports that SBNO1 protein is upregulated in several cancer entities. SBNO1 protein interacts with the basal transcription factor TFIID via TAF4, enabling its recruitment to transcription start sites and the modulation of target gene expression.
Sarah Fritzsche, Raisatun Nisa Sugiyanto, Kira Gür, Alina Krumme, Maxime Le Marois, Angelika Fraas, Aslihan Inal, Mario Huerta, Vanessa Henriques, Eva Eiteneuer, Thomas Albrecht, Alphonse Charbel, Michael T. Dill, Carsten Sticht, Carolina De La Torre, Stefan Pusch, Arianeb Mehrabi, Kai Breuhahn, Junfang Ji, Peter Schirmacher, Benjamin Goeppert, Stephanie Roessler   +21 more
wiley   +1 more source

Concluding remarks: Atmospheric chemistry in cold environments.

Faraday Discuss
Ammann M.
europepmc   +1 more source

Dynamic ice-ocean pathways along the Transpolar Drift amplify the dispersal of Siberian matter. [PDF]

Nat Commun
Laukert G, Bauch D, Rabe B, Krumpen T, Damm E, Kienast M, Hathorne E, Vredenborg M, Tippenhauer S, Andersen N, Meyer H, Mellat M, D'Angelo A, Simões Pereira P, Nomura D, Horner TJ, Hendry K, Kienast SS.   +17 more
europepmc   +1 more source

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

Advanced Science, EarlyView.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu, Yanzhi Feng, Qingqing Zhu, Ting Jiang, Yueyue Gao, Kebing Nie, Xianan Tang, Ying Chen, Dianxing Hu, Xudan Yang, Shixuan Wang, Meng Wu, Jinjin Zhang   +12 more
wiley   +1 more source

Exploring the potential of nest archives for establishing long-term trends in local populations of an Arctic-nesting colonial sea duck. [PDF]

PLoS One
Álvarez-Manzaneda I, Rühland KM, Campbell M, Duda MP, Mallory ML, Clyde N, Grant Gilchrist H, Hargan KE, Smol JP.   +8 more
europepmc   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source