Results 61 to 70 of about 36,960 (331)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Improvement of Ice Surface Temperature Retrieval by Integrating Landsat 8/TIRS and Operation IceBridge Observations

Remote Sensing, 2023
Accurate retrieval of ice surface temperature (IST) over the Arctic ice-water mixture zone (IWMZ) is significantly essential for monitoring the change of the polar sea ice environment.
Lijuan Song, Yifan Wu, Jiaxing Gong, Pei Fan, Xiaopo Zheng, Xi Zhao   +5 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Spatial Distribution of Methanesulphonic Acid in the Arctic Aerosol Collected during the Chinese Arctic Research Expedition

Atmosphere, 2015
Methanesulphonic acid (MSA, mainly derived from marine biogenic emissions) has been frequently used to estimate the marine biogenic contribution. However, there are few reports on MSA over the Arctic Ocean, especially the central Arctic Ocean.
Peipei Ye, Zhouqing Xie, Juan Yu, Hui Kang   +3 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Sea ice meiofauna distribution on local to pan‐Arctic scales

Ecology and Evolution, 2018
Arctic sea ice provides microhabitats for biota that inhabit the liquid‐filled network of brine channels and the ice–water interface. We used meta‐analysis of 23 published and unpublished datasets comprising 721 ice cores to synthesize the variability in
Bodil A. Bluhm, Haakon Hop, Mikko Vihtakari, Rolf Gradinger, Katrin Iken, Igor A. Melnikov, Janne E. Søreide   +6 more
doaj   +1 more source

Oil tanker under ice loadings

Scientific Reports, 2023
As a result of global warming, the area of the polar pack ice is diminishing, making merchant travel more practical. Even if Arctic ice thickness reduced in the summer, fractured ice is still presenting operational risks to the future navigation.
Oleg Gaidai, Ping Yan, Yihan Xing, Jingxiang Xu, Fuxi Zhang, Yu Wu   +5 more
doaj   +1 more source

Concentrations and snow-atmosphere fluxes of reactive nitrogen at Summit, Greenland [PDF]

, 1999
Concentrations and fluxes of NOy (total reactive nitrogen), ozone concentrations and fluxes of sensible heat, water vapor, and momentum were measured from May 1 to July 20, 1995 at Summit, Greenland. Median NOy concentrations declined from 947 ppt in May
Colman, A S, Dibb, Jack E., Fan, S M, Jacob, D J, Munger, J W   +4 more
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Automatic detection of Arctic polynyas using hybrid supervised-unsupervised deep learning [PDF]

The Cryosphere
Polynyas are open water or thin-ice areas within the ice pack. They play a crucial role for the Earth system, from deep water to cloud formation, causing large gas exchanges, and acting as hotspots for marine life.
C. Heuzé, C. H. M. Wong
doaj   +1 more source