Results 71 to 80 of about 57,296 (333)

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Sea-ice information and forecast needs for industry maritime stakeholders [PDF]

, 2020
Profound changes in Arctic sea-ice, a growing desire to utilize the Arctic’s abundant natural resources, and the potential competitiveness of Arctic shipping routes, all provide for increased industry marine activity throughout the Arctic Ocean.
Bhatt, Uma, Bourbonnais, Pascale, Fleming, Andrew, Hughes, Nick, Little, Joe, Rabenstein, Lasse, Stroeve, Julienne, Wagner, Penelope Mae, Wiggins, Helen   +8 more
core   +4 more sources

Sea ice meiofauna distribution on local to pan‐Arctic scales

Ecology and Evolution, 2018
Arctic sea ice provides microhabitats for biota that inhabit the liquid‐filled network of brine channels and the ice–water interface. We used meta‐analysis of 23 published and unpublished datasets comprising 721 ice cores to synthesize the variability in
Bodil A. Bluhm, Haakon Hop, Mikko Vihtakari, Rolf Gradinger, Katrin Iken, Igor A. Melnikov, Janne E. Søreide   +6 more
doaj   +1 more source

When Will Arctic Sea Ice Disappear? Projections of Area, Extent, Thickness, and Volume [PDF]

arXiv, 2022
Rapidly diminishing Arctic summer sea ice is a strong signal of the pace of global climate change. We provide point, interval, and density forecasts for four measures of Arctic sea ice: area, extent, thickness, and volume. Importantly, we enforce the joint constraint that these measures must simultaneously arrive at an ice-free Arctic.
arxiv  

The progress in the study of Arctic pack ice ecology [PDF]

, 2004
The sea ice community plays an important role in the Arctic marine ecosystem. Because of the predicted environmental changes in the Arctic environment and specifically related to sea ice, the Arctic pack ice biota has received more attention in recent ...
何剑锋, 李少菁, 王桂忠, 蔡明红   +3 more
core  

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Environmental drivers of under-ice phytoplankton bloom dynamics in the Arctic Ocean

Elementa: Science of the Anthropocene, 2020
The decline of sea-ice thickness, area, and volume due to the transition from multi-year to first-year sea ice has improved the under-ice light environment for pelagic Arctic ecosystems.
Mathieu Ardyna, C. J. Mundy, Matthew M. Mills, Laurent Oziel, Pierre-Luc Grondin, Léo Lacour, Gauthier Verin, Gert Van Dijken, Joséphine Ras, Eva Alou-Font, Marcel Babin, Michel Gosselin, Jean-Éric Tremblay, Patrick Raimbault, Philipp Assmy, Marcel Nicolaus, Hervé Claustre, Kevin R. Arrigo   +17 more
doaj   +1 more source

SAR image wave spectra to retrieve the thickness of grease-pancake sea ice using viscous wave models [PDF]

arXiv, 2020
Young sea ice composed of grease and pancake ice (GPI), as well as thin floes, considered to be the most common form of sea ice fringing Antarctica, is now becoming the 'new normal' also in the Arctic. Investigations to determine how an increase in GPI is affecting the climate in the far north and globally, require specific tools to monitor the GPI's ...
arxiv