Results 71 to 80 of about 36,960 (331)

2017 State-of the Science of Dispersants and Dispersed Oil (DDO) in U.S. Arctic Waters: Physical Transport and Chemical Behavior [PDF]

, 2017
Chemical dispersants were employed on an unprecedented scale during the Deepwater Horizon oil spill in the Gulf of Mexico, and could be a response option should a large spill occur in Arctic waters. The use of dispersants in response to that spill raised
Coastal Response Research Center (CRRC)
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

CLIMATE CHANGE AT HIGH LATITUDES: AN ILLUMINATING EXAMPLE

Zygon, 2018
A striking example is presented of a newly observed phenomenon in the ice‐covered Arctic Ocean that appears to be a consequence of changes in the physical forcing.
doaj   +2 more sources

Environmental drivers of under-ice phytoplankton bloom dynamics in the Arctic Ocean

Elementa: Science of the Anthropocene, 2020
The decline of sea-ice thickness, area, and volume due to the transition from multi-year to first-year sea ice has improved the under-ice light environment for pelagic Arctic ecosystems.
Mathieu Ardyna, C. J. Mundy, Matthew M. Mills, Laurent Oziel, Pierre-Luc Grondin, Léo Lacour, Gauthier Verin, Gert Van Dijken, Joséphine Ras, Eva Alou-Font, Marcel Babin, Michel Gosselin, Jean-Éric Tremblay, Patrick Raimbault, Philipp Assmy, Marcel Nicolaus, Hervé Claustre, Kevin R. Arrigo   +17 more
doaj   +1 more source

Sudden increase in Antarctic sea ice: Fact or artifact? [PDF]

, 2013
Copyright © 2011 American Geophysical UnionThree sea ice data sets commonly used for climate research display a large and abrupt increase in Antarctic sea ice area (SIA) in recent years.
Cavalieri, Cavalieri, Comiso, Comiso, Comiso, J. A. Screen, Markus, Meier, Meier, Parkinson, Parkinson, Rayner, Reynolds, Screen, Spreen, Stroeve, Zabel   +16 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Transitions of social-ecological subsistence systems in the Arctic [PDF]

, 2017
Transitions of social-ecological systems (SES) expose governance systems to new challenges. This is particularly so in the Arctic where resource systems are increasingly subjected to global warming, industrial development and globalization which ...
Clark, Douglas A., Fauchald, Per, Hausner, Vera, Schmidt, Jennifer   +3 more
core   +4 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Unprecedented Beaufort Sea ice loss in late summer 2021 and its relationship to an extended period of unusually stormy weather

Environmental Research Letters
Previous case studies have linked cyclone-induced atmospheric forcing and/or upper-ocean processes to notable Arctic sea ice loss events in the summers of 2012 and 2016.
Thomas J Ballinger, Peter M Finocchio, Vladimir A Alexeev, Igor V Polyakov, James D Doyle, Matthew G Fearon, Linette Boisvert, Chelsea Parker   +7 more
doaj   +1 more source